Glucophage or Siofor

What is Siofor

Siofor is a broad-spectrum medicine. It is most commonly used to treat type 2 diabetes. The drug does not completely cure the disease, but only temporarily restores the sensitivity of cells, so a person with diabetes should take Siofor throughout his life. When used, the main active ingredient is released almost immediately, and the so-called prolonged effect is absent.

It can also be used to treat other disorders. Studies show that long-term use of Siofor gradually removes harmful cholesterol from the body, so this medicine can be used to treat heart disease that appeared against the background of an increase in cholesterol concentration. Also pills can be used for weight loss.

In the body, the cycle of "hunger-satiety" directly depends on the concentration of glucose. If there is too much of it, then the person will experience an acute feeling of hunger. At the same time, carbohydrate metabolism in the body is arranged in such a way that a person still feels hunger for a rather long time during a meal, which often leads to overeating. Overeating gives your body extra calories that will be converted into fat, which will lead to weight gain. When taken, the sugar concentration is automatically reduced, which leads to a feeling of satiety. Due to this, it becomes easier for a person to control food intake, and the total amount of food decreases. Reducing the calorie content of food leads to increased metabolism and burning of subcutaneous fat, which leads to weight loss.

Siofor is available in tablet form. The dosage and method of administration of the drug depends on many parameters, but most often this medicine is drunk 1-2 tablets 3 times a day before meals. This technique is needed in order to suppress appetite in advance. At the same time, Siofor is prescribed quite often in combination with other hypoglycemic drugs, since Siofor is well combined with many substances.

Studies show that with the help of Siofor, you can lose 1-3 kg per week if you follow the dosage rules.

The drug has no side effects if the rules of admission are followed, however, in case of an overdose, disorders such as nausea, vomiting, dizziness, headache, abdominal pain, and so on may occur. In case of an overdose, you must urgently stop taking the drug and consult a doctor for advice (in case of acute poisoning, you can call an ambulance). There are also diseases in which to drink

Siofor is contraindicated:

  • Diseases of the liver and kidneys;
  • Age under 16;
  • Various disorders in which the production of insulin is completely or partially impaired (for example, type 1 diabetes);
  • Pregnancy and lactation;
  • Poor immunity and / or low hemoglobin in the blood;
  • Alcoholism;
  • Heart failure.

Main pharmacological properties

The active substance metformin is the same for these medicines. Thanks to him, it happens:

  • decreased sensitivity of cells to insulin;
  • decreased absorption of glucose in the intestine;
  • improving the sensitivity of cells to glucose.

What is the difference between Siofor and Glucophage? Let's figure it out.

The production of its own insulin is not stimulated by metformin, but only improves the response of the cells. The result is an improvement in carbohydrate metabolism in the body of a diabetic. Thus, the substance in the preparation:

  • reduces appetite - a person simply consumes less food, due to this excess weight is lost;
  • normalizes carbohydrate metabolism;
  • reduces weight;
  • reduces the concentration of sugar in the blood.

Complications of diabetes are less common with these medications. The risk of heart and vascular diseases is reduced. Diabetics so often suffer from this.

Each drug has its own dosage and duration of action, which is determined by the attending physician. There is a long-acting metformin. This means that the effect of lowering blood glucose levels lasts for a long time. The name of the medicine contains the word "long". Against the background of taking, for example, the drug "Glucophage Long", the level of bilirubin is leveled and protein metabolism is normalized. The prolonged drug is taken only once a day.

When choosing one or another drug, it is necessary to understand that if the active substance is the same for them, then the mechanism of operation will be similar.

People who suffer from diabetes often ask the question: which is better - "Siofor" or "Glucophage"? In this article, we will consider in more detail both the one and the other drug.

All prescriptions of medicines should be carried out by the attending physician. Self-medication is unacceptable. To exclude the occurrence of any adverse reactions from the body, it is necessary:

  • strictly follow the recommended diet;
  • exercise regularly (this can be swimming, running, outdoor games, fitness);
  • take the drug, observing the dosage and all other doctor's prescriptions.

If the attending physician did not name a specific medicine, but gave several names to choose from, then the patient can get acquainted with consumer reviews and buy the most suitable remedy for him.

So, which is better - "Siofor" or "Glucophage"? To answer this question, it is necessary to consider the properties of these drugs.

Contraindications

Both drugs have limitations in their use, which may affect the choice of one of them when prescribing drug therapy. After all, it depends to a large extent on contraindications whether a medicine will be prescribed to a particular patient.

A) Siofor cannot be called an absolutely harmless drug, and that is why it should be used only after prior consultation with a doctor. So, this medicine has a certain set of contraindications that exclude the possibility of its use in such cases:

  • type 1 diabetes mellitus (insulin dependent);
  • lack of insulin produced by the pancreas (sometimes this occurs in type 2 diabetes);
  • the presence of albumin and globulin proteins in the urine (observed with micro-, macroalbuminemia);
  • liver failure and the inability of the liver to cleanse the blood of toxins;
  • cardiovascular disease (due to the harmful effects of metformin);
  • lung disease;
  • a lowered level of hemoglobin in the blood;
  • simultaneous use with oral contraceptives (can lead to unplanned pregnancy);
  • individual intolerance to metformin or other components that make up the tablets;
  • pregnancy and lactation.

Also, this drug is prohibited from using in relation to patients in a coma, including ketoacidotic. People who have recently undergone surgery should also be struck off the list of those who are allowed to take Siofor. With regard to age restrictions, the drug is prohibited for use by children under 18 years of age and elderly people aged 60 and over, especially if the latter are engaged in physical labor.

Contraindications to Siofor include type 1 diabetes, in which the patient is forced to regularly inject himself with insulin. Nevertheless, there are times when the use of this metformin-based drug is advisable for such patients. We are talking about obesity, which is successfully treated with this drug in the presence of glycemic problems. Therefore, sometimes Siofor is best prescribed for insulin-dependent diabetes at the same time as insulin therapy in order to achieve faster treatment results.

B) Glucophage and Glucophage Long in general have contraindications similar to those listed above. Nevertheless, they have some important differences. So, the use of this medication is contraindicated in such pathologies:

  • type 1 diabetes mellitus;
  • diseases of the cardiovascular system (due to metformin);
  • kidney disease;
  • individual intolerance to metformin or other substances contained in tablets;
  • prolonged alcoholism (even in cases where the patient has already got rid of the addiction);
  • pregnancy and lactation;
  • a recently performed operation, after which the patient has not yet had time to fully rehabilitate.

It can be concluded that Siofor has a greater number of contraindications than Glucophage (Long). If the first excludes the possibility of use by people suffering from liver diseases, then the second is prohibited in the presence of renal pathologies

You should also pay attention to the fact that Glucophage can be taken with insufficient production of insulin in the body, which distinguishes it favorably from Siofor. We must also not forget about albuminemia and a low level of hemoglobin, in which the latter is categorically contraindicated.

The use of drugs

A) Siofor is usually prescribed for admission when a change in the patient's lifestyle could not significantly affect the picture of the disease. In particular, we are talking about adhering to a strict diet and exercise, which can have an impact on blood sugar levels. If these measures do not help, Siofor can act as a "compensator" for hyperglycemia, since it can affect the sensitivity of cells to insulin produced by the pancreas. In addition to this remedy, the patient may be prescribed medications to lower blood sugar levels. Thus, it is possible to get rid of hyperglycemia by influencing the situation from two directions: by increasing the intensity of glucose absorption and at the same time reducing its concentration in the blood. In individual cases, type 2 diabetics can be prescribed insulin therapy, which in combination with Siofor can improve the patient's condition.

Sometimes this drug is used as a monotherapy and, besides it, the patient does not need to take any other drugs. Physical activity and diet, however, continue to be the main measures aimed at combating high glucose levels. The effect of the medication comes about half an hour after ingestion. As for the dosage, Siofor is prescribed for admission in those doses that are suitable for a particular patient. There are no general standards in this case, and only a qualified doctor can make a decision on this matter.

B) The instruction for the analogue drug, which is also subject to consideration, has instructions about the dosage in which it is recommended for use, which distinguishes it favorably from Siofor. So, Glucophage tablets should be taken three times a day, about an hour before meals. The course of treatment with their use is three weeks, after which it is recommended to interrupt therapy for at least two months, since the drug can be addictive. Also, the instructions for the medicine contain instructions for a diet, which means:

  • refusal from sweet and high-calorie foods;
  • refusal of food containing carbohydrates of rapid digestibility;
  • inclusion in the diet of foods containing a large amount of fiber;
  • quitting alcohol and smoking.

The daily calorie content of food should not exceed 1800 kcal. Otherwise, Glucophage will not be able to prevent an abnormal increase in sugar levels, which may result in a worsening of the patient's condition.

It should also be noted that there is another type of drug - Glucophage Long, which has a prolonged effect. The effect of such a drug occurs in about ten hours, which is very different from its predecessor.

Thus, it can be concluded that both metformin-based drugs are intended for the same purposes and have a very similar mechanism of action. At the same time, Glucophage Long has clearer instructions for use, in contrast to Siofor, the dosage of which is set only by the attending physician. Significant differences also lie in the speed, which in Glucophage Long is slowed down in relation to Siofor by almost twenty times. From this it follows that the first remedy is better than the second in those cases when not an instant, but a gradual effect on the glycemic picture is required.

How to take the recommended doses and recipes correctly

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Instructions for use

The daily norm of Glucophage for weight loss should not exceed 2500 mg, i.e. 5 tablets of 500 mg.

How to use Glucophage Long 500:

  • We drink 1 tablet 2 or 3 times a day with meals;
  • The duration of the course is 3 months, then after the same time it can be repeated.

The rules for using Glucophage Long 750 are slightly different:

  • We divide the tablets into 2 parts, use half of them 4 times a day;
  • The length of the reception remains the same.

Glucophage 850 should be taken as follows:

  • Take 1 tablet three times a day with meals;
  • Be sure to drink 200 g of clean water.

How to use Glucophage 1000:

  • You can drink it only a week after you start using the drug in a lower dosage;
  • During meals, we drink 2-3 tablets twice a day, depending on the concentration of glucose in the blood - it must first be found out with the help of a glucometer.

Why take Glucophage: indications and contraindications

Compliance with a safe dosage of Glucophage significantly reduces the risk of side effects, but it is additionally recommended that you familiarize yourself with the indications and contraindications.

Indications for the use of Glucophage:

  • Type 2 diabetes mellitus;
  • Obesity;
  • Lack of effect from diets and physical activity;
  • Monotherapy in childhood.

Contraindications

  • Diabetic coma, ketoacidosis and precoma;
  • Renal failure;
  • Infectious diseases;
  • Intoxication;
  • Insulin therapy;
  • Liver disease;
  • Pregnancy;
  • Allergy to the components of the drug;
  • The introduction of the containing agent into the body less than 48 hours ago;
  • Alcoholism;
  • Lactic acidosis.

We also advise you to read the article on Happy-womens.com.

Similarities

The drugs are produced on the basis of the same substance. It is difficult to decide which is better than Glucophage or Metformin. They act in the same way on the body.

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Both drugs have similar contraindications. These include:

  • dysfunction of the liver, kidneys;
  • infectious diseases in which there is a risk of dehydration;
  • cardiovascular failure, in which tissue hypoxia is observed;
  • surgical interventions;
  • alcoholism or alcohol-based poisoning;
  • a low calorie diet;
  • pregnancy, breastfeeding.

The effect of both drugs on children is not well understood, therefore it is better to refrain from using persons under 18 years of age.

Patients over 60 years of age engaged in heavy physical labor are advised to carefully prescribe these drugs.

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During pregnancy, when planning such, these funds are replaced with insulin, due to the fact that there is not enough information about the effect on the fetus.

There was no negative effect of drugs on car control. Caution must be exercised in case of dizziness, headaches.

Metformin or Glucophage is taken with or after meals. They affect the digestive organs, therefore, treatment begins with minimal doses, gradually increasing.

Both drugs work well in monotherapy with diet and exercise. And in combination with other antidiabetic agents, when dietary food, exercise does not help.

The main component of these drugs helps patients in some cases to reduce weight by normalizing metabolism.

Both brands produce extended release tablets. The names Metformin Long and Glucophage Long. These are tablets containing 500, 750 mg, 1000 mg of the active substance. Such forms provide a delayed absorption of the substance, thereby ensuring the duration of its action.

To find out what is the difference between Glucophage and Metformin, you need to consult an endocrinologist.

The program "Let them talk" told about diabetes

Why do pharmacies offer outdated and dangerous drugs, while hiding from people the truth about the new drug ...

Characteristics of Glucophage

This is a drug that has a hypoglycemic effect. Release form - tablets, the active ingredient of which is metformin hydrochloride. It activates the production of insulin by affecting glycogen synthase, and also has a beneficial effect on lipid metabolism, reducing the concentration of cholesterol and lipoproteins.

With type 2 diabetes, doctors often prescribe drugs such as Glucophage or Siofor.

In the presence of obesity in a patient, the use of the drug leads to an effective decrease in body weight. It is prescribed for the prevention of type 2 diabetes in patients who have a predisposition to its development. The main component does not affect the production of insulin by the cells of the pancreas, so there is no risk of hypoglycemia.

Glucophage is prescribed for type 2 diabetes, especially for obese patients, if physical activity and diet have been ineffective. You can also use it with other drugs with hypoglycemic properties, or with insulin.

Contraindications:

  • renal / hepatic impairment;
  • diabetic ketoacidosis, precoma, coma;
  • severe infectious diseases, dehydration, shock;
  • diseases of the cardiovascular system, acute myocardial infarction, respiratory failure;
  • type 1 diabetes mellitus;
  • adherence to a low-calorie diet;
  • chronic alcoholism;
  • acute ethanol poisoning;
  • lactic acidosis;
  • surgical intervention, after which insulin therapy is prescribed;
  • pregnancy;
  • excessive sensitivity to components.

Renal failure is one of the contraindications for taking the drug.

Hepatic failure is one of the contraindications for taking the drug.

Pregnancy is one of the contraindications for taking the drug.

Type 1 diabetes mellitus is one of the contraindications to taking the drug.

In addition, it is not prescribed 2 days before and after the implementation of a radioisotope or X-ray examination, in which an iodine-containing contrast was used.

Adverse reactions include:

  • nausea, vomiting, diarrhea, loss of appetite, abdominal pain;
  • violation of taste;
  • lactic acidosis;
  • hepatitis;
  • rash, itching.

The simultaneous reception of Glucophage with other hypoglycemic agents can cause a decrease in concentration of attention, therefore, you need to drive a car and complex mechanisms with caution. ... Analogs include: Glucophage Long, Bagomet, Metospanin, Metadien, Langerin, Metformin, Glyformin

If there is a need for prolonged action, it is recommended to use Glucophage Long.

Analogs include: Glucophage Long, Bagomet, Metospanin, Metadien, Langerin, Metformin, Glyformin. If there is a need for prolonged action, it is recommended to use Glucophage Long.

Glucophage

The drug is indicated for stage II diabetes and problems with excess weight. In the second case, it is prescribed if exercise and diet were ineffective. Therefore, some believe that it can be used for weight loss (you must first consult with your doctor). Glucophage, like Siofor, is used to prevent diabetes mellitus.

The drug is for oral administration. Release form - tablets.

The mechanism of action of the drug

The main component in the composition is metformin, it is he who has a hypoglycemic effect. Glucophage, like Siofor, lowers blood sugar and inhibits the production of glucose in the liver. In addition, it increases the sensitivity of muscle fibers that capture and process glucose.

Suitable for the prevention of diabetes. When ingested, it affects the sugar level only if it is exceeded. If the glucose level is in order, then Glucophage has no effect on it.

Additionally, the drug has an effect on lipid metabolism. Reduces cholesterol levels.

Glucophage is absorbed in the gastrointestinal tract (gastrointestinal tract), with food intake, assimilation is slower. It is excreted from the body mainly by the kidneys, a smaller part through the stomach.

General instruction

The tablets must be drunk whole, not halving or crushing. Initially, a dose of 500 mg is prescribed, the drug is used 2-3 times a day. After two weeks, the glucose level is checked and the dosage changes depending on the changes.

The decision to increase / decrease the dose or discontinue the drug should be made by the attending physician. He also prescribes the medicine.

The maximum daily dose of the drug is 3 g. The maximum single dose is 1 g.

Side effects and overdose

In case of an overdose, the development of lactic acidosis is possible. In this case, the use of the drug is canceled. Control of the level of lactate and metformin in the body, as well as treatment of the consequences of an overdose is carried out in a hospital.

In the process of using Glucophage, the following side effects are possible:

  • nausea, vomiting, lack of appetite, abdominal pain, metallic taste in the mouth, flatulence, anorexia;
  • megaloblastic anemia;
  • impaired liver function;
  • allergic reactions (expressed as skin rash, redness, itching);
  • lactic acidosis.

When side effects appear, the person taking the medication should refuse it. Symptoms will subside within a few days / a week. If you experience side effects, you should consult your doctor.

Who should not take medication?

Contraindications Glucophage has exactly the same as Siofor. In short, these are:

  • personal intolerance to the components;
  • impaired renal and liver function;
  • alcoholism;
  • lactic acidosis;
  • pregnancy and lactation.

Glucophage

Glucophage is a hypoglycemic drug belonging to the biguanide class. The action of its active substance leads to a decrease in glucose levels, without increasing the production of its own hormone. Without causing a hypoglycemic effect.

Glucophage affects the body in three ways:

  1. By inhibiting gluconeogenesis and glyconolysis, it reduces the production of glucose by liver cells.
  2. Improves insulin sensitivity of muscle cells.
  3. Delays the absorption of glucose by the intestines.

Regardless of glucose levels, the drug lowers cholesterol, mobilizes fatty acids as the main source of fuel, and promotes the treatment of obesity.

The maximum concentration of the active substance is reached three hours after ingestion. Sixty percent relative bioavailability. The absorption of the drug is almost independent of food intake.

The drug is prescribed:

  • As the main therapy for type 2 diabetes, with the ineffectiveness of other treatments.
  • As part of complex therapy in the treatment of children and adolescents.
  • In the treatment of type 2 diabetes, complicated by the presence of excess weight.

Varieties of medicines

Both drugs are made by manufacturers from different countries. , therefore, they have slight differences in the form of release and cost. At the beginning of November 2018, the price of Metformin varies between 9-608 rubles, and for Glucophage - 43-1500 rubles. The difference depends on the dosage, the duration of the drug, the place of manufacture, the number of tablets in one package.

Varieties of hypoglycemic agents in the table:

Comparison parameter

Metformin

Glucophage

Dosing of metformin substance in one tablet with normal release rate 500 mg, 850 mg, 1000 mg 500 mg, 850 mg, 1000 mg
Dosing of metformin in one sustained-release tablet 500 mg, 750 mg, 850 mg, 1000 mg 500 mg, 750 mg, 1000 mg
Tablet coating types Regular release metformin is available uncoated or with film or enteric coating Glucophage tablets of conventional action are film-coated
Sustained-release tablets are coated with a film-type coating or are made without it. Glucophage Long is produced without a shell
Place of production of drugs Russia: Izvarino Pharma, Biochemist, Canonpharma Production, Vertex, Rafarma, Biosynthesis, Ozone, Medisorb France: Merck Sante
Serbia: Hemofarm Spain, Germany: Merck
Belarus: Borisov plant of medications Russia: Nanolek
Czech Republic, Slovakia: Zentiva
Israel: Teva
Hungary: Gedeon Richter
Synonyms for Metformin and Glucophage Glyformin, Langerin, Diaformin, Metfogamma, Siofor, Metospanin, Sopamet, Novoformin, Formetin, other absolute analogues (one-component drugs with metformine)
Two-way products that contain metformine Galvus Met, Baghomet Plus, Glymecomb, Amaryl M, Avandamet, Yanumet
Nosological analogues (drugs with hypoglycemic substances) Vildagliptin, Glibenclamide, Gliclazide, Glimepiride, Rosiglitazone, Sitagliptin

Attention! It is forbidden to supplement the action of Metformin tablets with Glucophage at the same time. Both drugs are absolute analogues of each other, therefore, an overdose of metformin occurs

Absolutely forbidden

All drugs that are based on metformin hydrochloride have a number of contraindications and side effects, and improper use can lead to irreparable consequences. Particularly carefully consider the possibility of a negative effect of the drug if a woman uses these diet pills.

Despite the slight difference between the drug Glucophage and Metformin, both drugs can lead to the following problems:

  • The possibility of anorexia appears;
  • Leads to a significant decrease in vitamin B, and this forces the patient to take another drug supplement;
  • Negative symptoms (diarrhea, nausea, abdominal pain);
  • The risk of developing pathologies of the digestive tract organs;
  • Skin pathologies (allergic rashes, irritations);
  • Anemia;
  • Changes in taste (for example, metal taste).

Incorrect intake of these funds leads to a slight accumulation of the active substance in the body, and this forms lactic acidosis. The condition of kidney disease is aggravated. You can not prescribe the drug to pregnant women and women who are breastfeeding. If one of the components is intolerant, they do not drink the medicine. Such medicines are contraindicated for heart failure, with a previous myocardial infarction.

Comparison of Glucophage and Metformin

Glucophage and Metformin have the same active ingredient, the same release forms and dosages, and are complete analogues of each other.

Similarity

The drugs have the same pharmacological action, which boils down to activation:

  • peripheral receptors and increasing their sensitivity to insulin;
  • transmembrane glucose transporters;
  • the process of utilizing glucose in tissues;
  • the synthesis of glycogen.

Glucophage and Metformin have the same active ingredient.

In addition, metformin hydrochloride reduces the amount of glucose produced by the liver, lowers the content of cholesterol, low density lipoproteins and thyroid hormones in the blood, and slows down the absorption of carbohydrates in the intestine.

This substance has a bioavailability of 50-60%; it is excreted by the kidneys practically unchanged.

The dosage is selected by the doctor individually. Manufacturers recommend starting with 500 mg 2-3 times a day, if necessary, increasing a single dose as the body adapts and improves tolerance. The amount of active ingredient taken per day should not exceed 3 g for adults and 2 g for children.

These medicines can cause a number of negative side effects. Among them:

  • lactic acidosis;
  • impairment of absorption of vitamin B12;
  • violation of taste, loss of appetite;
  • rash and other skin reactions;
  • violations in the liver;
  • dyspeptic symptoms, as well as vomiting and diarrhea, leading to dehydration of the body.

To improve tolerance, it is recommended to split the daily dose into several doses. People over 60 years old and engaged in hard physical labor are at an increased risk of complications.

Both drugs can induce loss of appetite.

Both Glucophage and Metformin can cause rashes and other skin reactions.

In some cases, medications can cause liver problems.

Sometimes during medication therapy, patients may be disturbed by vomiting.

Medication can cause diarrhea.

Since the active substance of both drugs is excreted by the kidneys, it is necessary to check their function regularly, at least once a year, despite the fact that metformin hydrochloride does not cause polyuria and other urinary disorders.

These medicines have the same contraindications and are prohibited for use in the following conditions:

  • impaired renal function or a high risk of their development;
  • tissue hypoxia or diseases leading to its development, for example, a heart attack, heart failure;
  • liver failure;
  • surgical operations if necessary for insulin therapy;
  • chronic alcoholism, acute alcohol intoxication;
  • pregnancy;
  • hypocaloric diet;
  • lactic acidosis;
  • studies using iodine-containing contrast media.

Both medications have a long-acting form, denoted by the "long" marker. This drug is taken once a day and monitors the glucose level for 24 hours.

What is the difference?

The difference in drugs is solely due to the fact that they are produced by different pharmaceutical companies, and consists in:

  • the composition of excipients in a tablet and a shell;
  • price.

Do not take medications for impaired renal function.

Treatment with medications for heart failure is not allowed.

Chronic alcoholism is a contraindication to the use of both drugs.

Which is cheaper?

In one of the online pharmacies, Glucophage in a package of 60 tablets can be purchased at the following cost:

  • 500 mg - 178.3 rubles;
  • 850 mg - 225.0 rubles;
  • 1000 mg - 322.5 rubles.

At the same time, the price of a similar amount of Metformin is:

  • 500 mg - from 102.4 rubles. for the drug produced by Ozone LLC, up to 210.1 rubles. for a medicine manufactured by Gedeon Richter;
  • 850 mg - from 169.9 rubles. (OOO Ozon) up to 262.1 rubles. (Biotek LLC);
  • 1000 mg - from 201 rubles. (Sanofi company) up to 312.4 rubles (Akrikhin company).

The cost of drugs containing metformin hydrochloride does not depend on the brand name, but on the pricing policy of the manufacturer. Metformin can be purchased for about 30-40% cheaper by choosing tablets made by Ozone LLC or Sanofri.

With type 2 diabetes, doctors often prescribe drugs such as Glucophage or Siofor. They both show efficacy in this condition. Thanks to these medications, cells become more sensitive to the effects of insulin. Such drugs have advantages and disadvantages.

Characteristics of Glucophage

This is a drug that has a hypoglycemic effect. Release form - tablets, the active ingredient of which is metformin hydrochloride. It activates the production of insulin by affecting glycogen synthase, and also has a beneficial effect on lipid metabolism, reducing the concentration of cholesterol and lipoproteins.

In type 2 diabetes, doctors often prescribe drugs such as Glucophage or Siofor

With type 2 diabetes, doctors often prescribe drugs such as Glucophage or Siofor.

In the presence of obesity in a patient, the use of the drug leads to an effective decrease in body weight. It is prescribed for the prevention of type 2 diabetes in patients who have a predisposition to its development. The main component does not affect the production of insulin by the cells of the pancreas, so there is no risk of hypoglycemia.

Glucophage is prescribed for type 2 diabetes, especially for obese patients, if physical activity and diet have been ineffective. You can also use it with other drugs with hypoglycemic properties, or with insulin.

Contraindications:

  • renal / hepatic impairment;
  • diabetic ketoacidosis, precoma, coma;
  • severe infectious diseases, dehydration, shock;
  • diseases of the cardiovascular system, acute myocardial infarction, respiratory failure;
  • type 1 diabetes mellitus;
  • adherence to a low-calorie diet;
  • chronic alcoholism;
  • acute ethanol poisoning;
  • lactic acidosis;
  • surgical intervention, after which insulin therapy is prescribed;
  • pregnancy;
  • excessive sensitivity to components.

In addition, it is not prescribed 2 days before and after the implementation of a radioisotope or X-ray examination, in which an iodine-containing contrast was used.

Adverse reactions include:

  • nausea, vomiting, diarrhea, loss of appetite, abdominal pain;
  • violation of taste;
  • lactic acidosis;
  • hepatitis;
  • rash, itching.

The simultaneous reception of Glucophage with other hypoglycemic agents can cause a decrease in concentration, so you need to drive a car and complex mechanisms with caution.

Analogs include: Glucophage Long, Bagomet, Metospanin, Metadien, Langerin, Metformin, Glyformin. If there is a need for prolonged action, it is recommended to use Glucophage Long.

Siofor's characteristic

It is a drug that helps lower blood glucose levels. Its main component is metformin. It is made in the form of tablets. The drug effectively lowers postprandial and basal sugar concentration. It does not cause hypoglycemia because it does not affect insulin production.

Metformin inhibits glycogenolysis and gluconeogenesis, as a result of which the production of glucose in the liver decreases and its absorption improves. Thanks to the action of the main component on glycogen synthetase, intracellular glycogen production is stimulated. The drug normalizes impaired lipid metabolism. Siofor reduces the absorption of sugar in the intestine by 12%.

A medication is indicated for patients with type 2 diabetes mellitus if diet and exercise have not brought the desired effect. It is especially recommended for overweight patients. The drug is prescribed both as a single drug and in combination with insulin or other diabetes medications.

Siofor - a drug that helps to lower blood glucose levels

Siofor is a drug that helps lower blood glucose levels.

Contraindications include:

  • diabetic ketoacidosis and precom;
  • renal / hepatic impairment;
  • lactic acidosis;
  • type 1 diabetes;
  • recent myocardial infarction, heart failure;
  • a state of shock, respiratory failure;
  • impaired renal function;
  • severe infectious diseases, dehydration;
  • the introduction of a contrast agent containing iodine;
  • adhering to a diet that consumes foods low in calories;
  • pregnancy and lactation;
  • individual intolerance to the components of the medication;
  • age up to 10 years.

During Siofor therapy, alcohol consumption should be excluded, because this can lead to the development of lactic acidosis - a severe pathology that occurs when lactic acid accumulates in the bloodstream.

Adverse reactions occur infrequently. These include:

  • nausea, vomiting, decreased appetite, diarrhea, abdominal pain, metallic taste in the mouth;
  • hepatitis, increased activity of liver enzymes;
  • hyperemia, urticaria, pruritus;
  • violation of taste;
  • lactic acidosis.
While taking Siofor, a side effect in the form of nausea may appear.

While taking Siofor, a side effect in the form of nausea may appear.

2 days before the operation, during which general anesthesia, epidural or spinal anesthesia will be used, it is necessary to stop taking pills. Their use is resumed 48 hours after the surgery. To ensure a stable healing effect, Siofor should be combined with daily exercise and diet.

Analogs of the drug include: Glucophage, Metformin, Glyformin, Diaformin, Bagomet, Formetin.

Comparison of Glucophage and Siofor

Similarity

The drugs include metformin. They are prescribed for type 2 diabetes in order to normalize the patient's condition. Medicines are produced in the form of tablets. They have the same indications for use and side effects.

Glucophage is available in the form of tablets

Glucophage is available in tablet form.

What is the difference

Medicines have slightly different restrictions on their use. Siofor cannot be used if there is insufficient insulin production in the body, but Glucophage is possible. The first drug needs to be used several times a day, and the second one - once a day. They also differ in price.

Which is cheaper

Siofor's price - 330 rubles, Glucophage - 280 rubles.

Which is better - Glucophage or Siofor

When choosing between drugs, the doctor takes into account many factors. Glucophage is prescribed more often, because it does not irritate the intestines and stomach as much.

With diabetes

Taking Siofor does not lead to addiction to lowering blood sugar, and when using Glucophage, there are no sharp jumps in blood glucose levels.

Taking Siofor does not lead to addictive lowering of blood sugar

Taking Siofor does not lead to an addictive lowering of blood sugar.

Slimming

Siofor effectively reduces weight because suppresses appetite and speeds up metabolism. As a result, a diabetic patient can lose several pounds. But this result is observed only while taking the medication. After its cancellation, the weight quickly regains.

Effectively reduces weight and Glucophage. With the help of the drug, the disturbed lipid metabolism is restored, carbohydrates are less broken down and absorbed. Decreased insulin release leads to decreased appetite. Cancellation of the drug does not lead to rapid weight gain.

Reviews of doctors

Karina, endocrinologist, Tomsk: “Glucophage is prescribed for diabetes and obesity. It helps to effectively get rid of excess weight without causing harm to health, it is good for lowering blood sugar. Some patients may have diarrhea while taking the drug. "

Lyudmila, endocrinologist: “I often prescribe Siofor to my patients with type 2 diabetes, conditions of prediabetes. For many years of practice, he proved his effectiveness. Sometimes flatulence and abdominal discomfort may develop. These side effects go away after a while. "

Patient reviews about Glukofazh and Siofor

Marina, 56 years old, Oryol: “I have been suffering from diabetes for a long time. I have tried many different drugs that are designed to lower blood glucose. At first, they helped, but after getting used to it, they became ineffective. A year ago, the doctor prescribed Glucophage. Taking the medication helps to keep the sugar level in the norm, and no addiction has arisen during this time. "

Olga, 44 years old, Inza: “Siofor was appointed by an endocrinologist several years ago. The result appeared after 6 months. My blood sugar levels returned to normal and my weight decreased slightly. At first, there was such a side effect as diarrhea, which disappeared after the body got used to the drug. "

It is a hypoglycemic drug that has long been used in endocrinology to correct hyperglycemia in patients with type 2 diabetes mellitus.

This agent belongs to the biguanide group, but in addition to this group, there are also other types of drugs that reduce the concentration of glucose in the blood (sulfonylurea derivatives, secretogi, alpha-glycosidase antagonists and glinides).

The main feature of biguanides, which distinguishes it from the background of other antidiabetic drugs, is that it is also able to effectively reduce excess weight. Despite the attractiveness of the prospect of losing weight with pills, you should always remember that any drug treatment has a risk of complications.

That is why weight loss with the help of medication is indicated only for people with severe obesity. In all other cases, doctors and nutritionists recommend getting rid of excess fat accumulations in non-drug ways (sports and nutritional correction).

How Siofor differs from Glucophage, which is more effective in diabetes

If for any reason you need to change the specified medical device, analogues for its replacement must be selected without fail only in conjunction with the attending physician. He has the appropriate specialization and is aware of all the features of antihyperglycemic drugs.

Analogs

There are many medicines that can replace medicines. However, here you need to decide what goals the treatment pursues. If the pills were taken to combat obesity, then it should be borne in mind that not all drugs for the treatment of non-insulin dependent diabetes mellitus may be suitable for this.

Some analogs have the same active ingredient as the described medicine, so you need to remember that if you were allergic to it, then with a high degree of probability there will be intolerance to these direct analogs.

Do not self-medicate and always seek the advice of a specialist. Self-change can lead to the development of detrimental effects on health and well-being.

What to choose for diabetes: Siofor or Glucophage

How Siofor differs from Glucophage, which is more effective in diabetes

Siofor has the same main active ingredient. That is why these pharmaceuticals are very similar to each other. Some doctors are inclined to believe that Glucophage is safer, as it contains fewer auxiliary chemical compounds. But studies that could confirm or deny this fact have not yet been conducted.

It has a more prolonged therapeutic effect and does not cause sharp jumps in the concentration of glucose in the blood. Also, an important factor that can affect the choice of a drug is the fact that Glucophage is an order of magnitude cheaper than Siofor.

What to choose when losing weight: Siofor or Glucophage

How Siofor differs from Glucophage, which is more effective in diabetes

Based on the fact that the main biologically active components of both drugs is metformin, it would be correct to say that they have the same effect on metabolism and therefore equally contribute to the burning of excess fat deposits.

However, it is worth noting that each person has an individual sensitivity to drugs, so Glucophage helps some people better, while others feel the stronger effect of Siofor.

But most of the patients who have used both of these weight loss products claim to have not noticed any significant difference between the two.

It should be borne in mind that in addition to taking these medicines, you also need to change your lifestyle in order for the results to be more meaningful.

Glucovance as an analogue

How Siofor differs from Glucophage, which is more effective in diabetes

The fundamental difference between these two pharmaceuticals is that Glucovans refers to combined drugs, that is, those in which there are several active ingredients at once. These components (glibenclamide and metformin) belong to different pharmacological groups of sugar reducing agents.

Glibenclamide is a typical representative of the second generation of sulfonylurea derivatives, and Metformin is biguanides. Glucovans can be called a more effective drug for the treatment of diabetes, since it realizes its therapeutic effects through several mechanisms of biological action at once. Glucophage is recommended for patients with a more stable course of the disease.

What is better to choose for patients with diabetes mellitus: Metmorphin or Glucophage

How Siofor differs from Glucophage, which is more effective in diabetes

Both drugs have the same main components, which provide the strong similarity of these drugs. The advantage of the second is that it is also available in extended-release form. Thus, the medicine can only be taken once a day. This fact can significantly increase patient adherence to treatment.

Even doctors still cannot come to a unanimous opinion about which is more effective: Glucophage or Metformin, since the difference between them is completely insignificant. Therefore, you need to focus on the individual response of each individual patient to these drugs.

Metmorphine or Glucophage: which is better for weight loss

Both medicines can be prescribed with equal success to patients requiring medical correction of body weight. Both of these drugs normalize carbohydrate metabolism:

  • increase the consumption of glucose by tissues;
  • a decrease in its concentration in the bloodstream.

Also, drugs normalize fat metabolism, reduce the amount of harmful lipoproteins in the blood plasma, which have an atherogenic effect on blood vessels. In addition, both medications affect hunger, weakening it and reducing food cravings.

In order to make the process of losing weight faster and more effective, a combination of taking pills with an increase in physical activity (morning exercises, fitness, yoga) and normalization of nutrition (inclusion of a large amount of fiber, fresh vegetables, fruits and berries in the diet as an alternative to sweets) is required.

Glyformin and Glucophage: Comparative Characteristics

How Siofor differs from Glucophage, which is more effective in diabetes

Both medicines belong to the category of oral tablets with a hypoglycemic effect. Their composition is almost identical, and there are differences only in the content of various auxiliary chemical components. Doctors consider these drugs to be equally effective in treating people with insulin-dependent diabetes mellitus and concomitant obesity.

Patients who alternately took these two medicines, in most cases, did not notice any difference between them. However, there were cases of intolerance to one of the drugs, but this already depends on the individual characteristics of the patient's body.

Diabetone as a substitute

How Siofor differs from Glucophage, which is more effective in diabetes

Diabeton belongs to the group of sulfonylurea derivatives and realizes its therapeutic effects by stimulating the production of insulin by the islet cells of the pancreas. Diabetone is able to reduce the concentration of sugar in the blood plasma, but it does not affect the patient's weight in any way. That is, it does not make sense for obese patients to take Diabeton.

When to use Formetin as an analogue

Formetin also contains Metformin, so the effects of these drugs are very similar to each other. Formetin can also be prescribed to patients with excessive deposition of subcutaneous and visceral fat. Both medicines are recognized as effective and safe.

Comparison table of drug analogues by cost. The last data update was on 21.10.2019 00:00.

List of other analogues

In addition to the above drugs, the following pharmaceuticals can be substitutes:

  • Reduksin Met.
  • Baghomet.
  • Metformin-Teva.
  • Glickvidone.
  • Gliclazide.
  • Acarbose.
  • Glucobay.

The more carefully and responsibly you approach the selection of an analogue drug, the less likely it will develop any complications and side reactions.

Comparison table of drug analogues by cost. The last data update was on 21.10.2019 00:00.

Testimonials

  • Evgenia, 37 years old. Since childhood, I have been overweight, but after the second birth, the situation became downright critical, the weight mark went over 100 kg. I turned to a nutritionist for help. After passing the tests, I was diagnosed with a violation of tolerance to carbohydrates, I was immediately prescribed Glucophage. I drank it for a month and threw off 3.5 kilograms, but then it was not in pharmacies, and the doctor recommended taking Metformin. For a month of taking Metformin, I threw off 4 kilograms, but in addition to the pills, I began to go to the pool for aqua aerobics. I try to limit sweets and also not eat at night. I continue to take Metformin.
  • Gregory, 45 years old. Three years ago I was diagnosed with type 2 diabetes. Also, I am overweight. During this time, I was treated alternately with two hypoglycemic drugs: Siofor and Glucophage. I did not notice much difference between them, so for me these pills are absolutely equivalent. They help fight blood sugar levels, but they did not affect weight loss in any way.

A source: https://heart-info.ru/lekarstva/analogi-gljukofazha/

Siofor or Glukofazh: which is better for diabetes, indications, contraindications

Often diabetics ask themselves the question: "Which drug is better, Siofor or Glucophage?" You can answer this question by considering the properties of both drugs.

Siofor

How Siofor differs from Glucophage, which is more effective in diabetes

Siofor is considered the most demanded drug in the world as a prevention and treatment for type 2 diabetes.

The drug is mainly composed of metformin, which helps cells restore insulin sensitivity, thereby preventing insulin resistance. .

In addition, Siofor helps to lower the amount of cholesterol in the blood and reduce the risk of developing cardiovascular diseases. But its undoubted advantage is a gradual and effective weight loss.

Application

The main diagnosis for Siofor's use is type 2 diabetes mellitus, its prevention and treatment. Most often should be taken if diet and physical activity have not been effective.

Siofor tablets should be taken both as a single drug and in combination therapy. Most often with drugs that lower the concentration of glucose in the blood (antidiabetic tablets, insulin injections).

It is worth taking the drug with or after meals. You can increase the dose, but it should be done gradually and after consulting a specialist.

Contraindications

There are certain diseases and conditions in which Siofor is prohibited.

  1. Type 1 diabetes mellitus (an exception is the presence of obesity, which is treated with this drug).
  2. Lack of insulin produced by the pancreas (can occur in the second type).
  3. Coma and ketoacidotic coma.
  4. Micro and macroalbuminemia and uria (content of albumin and globulin proteins in urine and blood).
  5. Diseases of the liver and its insufficient detoxification function.
  6. Insufficient work of the heart and blood vessels.
  7. Shortness of breath.
  8. Decreased level of hemoglobin in the blood.
  9. Surgery and trauma.
  10. Excessive alcohol consumption.
  11. Pregnancy and lactation period.
  12. Children under 18.
  13. Individual intolerance to the drug substances.
  14. Taking oral contraceptives, as the risk of an unplanned pregnancy increases.
  15. Seniors after 60 who are busy with hard work.

Siofor for weight loss

The drug Siofor is not considered a remedy, the main purpose of which is to get rid of excess weight. However, many reviews and clinical trials prove that this drug is excellent for weight loss. The tablets reduce appetite and help speed up the metabolism. This helps to get rid of a few pounds of excess weight.

However, the effect lasts only for the duration of the drug intake. After its elimination, weight is quickly restored, mainly due to body fat.

However, there are advantages of Siofor over other drugs. It has a minimal number of side effects. Perhaps only a rumbling in the stomach, diarrhea and slight bloating. The price is also lower than some analogues, which makes this drug affordable for most.

How Siofor differs from Glucophage, which is more effective in diabetes

Taking Siofor tablets and not following a low-carb diet means not moving the weight off the ground. Getting rid of extra pounds is possible only if you follow a diet and have physical activity.

Taking a larger amount of the drug can lead to a lactic acidotic state, which is dangerously fatal. Therefore, in the hope of losing weight faster, it is better to run more than to increase the recommended dose.

Siofor for type 2 diabetes mellitus

The basic rules for preventing type 2 diabetes include having a healthy lifestyle. Given the state of the population, prevention can include a change in the quality of nutrition and an increase in physical activity.

However, only a few adhere to this rule. For the majority, Siofor must be taken as a weight loss aid.

However, the drug cannot help you achieve the desired results without diet and physical activity.

Glucophage

The drug Glucophage can be considered an analogue of Siofor for type 2 diabetes. To some extent, it is better, but there are also negative aspects.

The main advantage is that Glucophage Long has a prolonged action, that is, metformin is released from the drug within 10 hours. While Siofor stops working in half an hour. However, there is also a non-prolonged Glucophage.

How Siofor differs from Glucophage, which is more effective in diabetes

Why is Glucophage better than Siofor?

  1. Siofor has its own dosage and it is better to take it several times a day. Glucophage tablets are taken only once a day.
  2. There are significantly fewer side effects from the gastrointestinal tract, mainly due to less intake.
  3. There are no sharp changes in blood glucose concentration, especially in the morning and at night.
  4. Despite the lower dosage, it is not inferior to Siofor in lowering glucose.

Just like Siofor tablets, Glucophage is prescribed for type 2 diabetes mellitus and weight loss is a pleasant side effect.

What is the reason for the effect of weight loss?

  1. Impaired lipid metabolism in the body is restored.
  2. Carbohydrates are much less broken down in the body, which means that they are less absorbed and converted into fat.
  3. Normalizes the concentration of glucose in the blood and lowers the amount of cholesterol.
  4. Decreased appetite due to decreased insulin release.

Application

Taking Glucophage tablets for type 2 diabetes is necessary in combination with a diet.

  1. It is necessary to exclude from the diet foods that increase the concentration of glucose.
  2. Complete elimination of fast carbohydrates.
  3. Increasing the amount of foods rich in fiber (flour products from wholemeal flour, vegetables, legumes).

The total calorie content of food should not exceed 1800 kcal per day. In addition to dietary restrictions, it is necessary to get rid of some bad habits. It is necessary to completely exclude the use of alcohol during treatment. Smoking reduces absorption, which means that the amount of nutrients will reach the right place much less.

Physical activity is also required while taking the drug.

You need to take Glucophage tablets three times a day one hour before meals. The course of treatment is not more than 20 days, after a break within 2 months, you should repeat the reception. This is because the drug can be addictive.

Contraindications

  1. The presence of type 1 diabetes mellitus.
  2. The period of gestation and lactation.
  3. After surgery or injury.
  4. Diseases of the CVS.
  5. Kidney disease.
  6. Individual intolerance to the drug substances.
  7. Chronic alcoholism.

Side effects

  1. Dyspeptic disorders as in poisoning.
  2. Headache.
  3. Flatulence.
  4. Diarrhea.
  5. Increased body temperature.
  6. Weakness and fatigue.

These symptoms are associated with taking a high dose of the drug or not following a low-carb diet, which is especially important for type 2 diabetes.

If side effects appear, it is worth immediately reducing the amount of the drug by 2 times, that is, taking it 3 times a day, but half a pill. And seek advice from a specialist.

What is still better

Both of these drugs are analogs, so it's impossible to say who is better. They will affect each person uniquely.

  1. Since Glucophage has a little more side effects, in this regard it is slightly worse than its counterpart.
  2. However, Siofor has more contraindications.
  3. If there is an intolerance to the components of the drug, then you can try to take Glucophage of prolonged action.
  4. For the price, both drugs practically do not differ, however, Glucophage is somewhat more expensive. Glucophage long is more expensive than usual, so you should also pay attention to the price.
  5. The difference in drug intake does not significantly affect whether it is better or not.

Now it is clear that these drugs are practically indistinguishable, but if you need a prolonged action, you can use Glucophage Long.

A source: https://diabetsaharnyy.ru/lechenie/sravnenie-svojstv-preparatov-siofor-i-glyukofazh.html

Glucophage or Siofor: which is better?

Glucophage or Siofor is used for the treatment and prevention of type 2 diabetes mellitus. Both drugs are almost identical in composition and differ little in their effects on the body.

How Siofor differs from Glucophage, which is more effective in diabetes

Glucophage or Siofor is used for the treatment and prevention of type 2 diabetes mellitus.

Characteristics of Glucophage

The main active ingredient is metformin hydrochloride. Additional components: hypromellose, povidone, magnesium stearate. Action of the drug: reduces the absorption of sugar and increases the response of cells to insulin, muscle cells remove it faster. Metformin is unable to stimulate the body to produce its own insulin.

Used to treat the underlying disease and in the presence of obesity. Weight loss is up to 2-4 kg per week.

Release form: tablets with a dosage of 500, 850 and 1000 mg of the main component. Reception: 2 to 3 times a day, 1 tablet during or after meals to reduce irritation of the digestive system. The tablets are swallowed whole; they cannot be bitten and ground into powder.

The course of admission is 3 weeks. After 1.5-2 weeks, the amount of sugar in the blood is measured and the dose is adjusted. To avoid addiction, at the end of therapy, you will need to take a break for 2 months. If necessary, prolonged action is prescribed an analogue of Glucophage Long.

When treating the disease, it is necessary not to deviate from a low-calorie diet, designed for 1800 kcal. You should exclude the use of alcohol and stop smoking - this prevents the absorption and distribution of the drug.

Side effects:

  • migraine;
  • diarrhea;
  • dyspepsia (as with poisoning);
  • flatulence;
  • weakness;
  • fast fatiguability;
  • an increase in body temperature.

Contraindications:

  • type 1 diabetes mellitus;
  • diseases of the vascular system and heart;
  • diseases of the nephrological type;
  • carrying a fetus and breastfeeding;
  • recovery period after surgery;
  • chronic alcoholism;
  • intolerance to one of the components of the drug.

How Siofor differs from Glucophage, which is more effective in diabetes

Side effects of Glucophage: migraine, diarrhea.

In case of complications, the dose is reduced by 2 times to 1/2 tablet per single dose.

Siofor's characteristic

Siofor is also used to treat type 2 diabetic pathology. The main active ingredient is metformin. It acts on the receptors of cells, increases their sensitivity to insulin, improves the functioning of the cardiovascular system, promotes weight loss and improves concentration. The drug begins to work 20 minutes after ingestion.

Dose in tablets: 500, 850 and 1000 mg. Additional substances: titanium silicon dioxide, magnesium stearate, povidone, hypromellose, macrogol.

Usage regimen: start treatment with 500 mg, then increase to 850 mg, in special cases up to 1000 mg. It is recommended to take tablets 2-3 times a day during or after meals. During Siofor therapy, glucose control is carried out every 2 weeks.

Indications for use:

  • treatment of type 2 diabetes mellitus;
  • disease prevention;
  • overweight;
  • impaired lipid metabolism.

The medicine is effective for low-calorie diet and exercise. It is possible to take the drug at the same time with other medicines.

Contraindications:

  • type 1 diabetes mellitus with insulin injections;
  • detection of albumin and globulin proteins in urine;
  • liver failure and the inability of the organ to cleanse the blood of toxins;
  • diseases of the vascular system;
  • lung disease and breathing problems;
  • low hemoglobin;
  • taking funds from unwanted pregnancy, because Siofor neutralizes their action;
  • pregnancy and lactation;
  • individual intolerance to the constituents of the product;
  • chronic alcoholism;
  • diarrhea;
  • coma;
  • postoperative period;
  • children and persons over 60 years old.

The following side effects are possible:

  • rumbling in the stomach;
  • slight bloating;
  • nausea;
  • bowel disorder;
  • vomiting;
  • metallic taste;
  • stomach ache;
  • allergic rashes;
  • lactic acidosis;
  • violations of the basic functions of the liver.

How Siofor differs from Glucophage, which is more effective in diabetes

Side effects of Siofor are possible: rumbling in the stomach, slight bloating.

To reduce the manifestation of unpleasant symptoms, the daily dose should be divided into several doses.

Comparison of drugs

Both medicines have more similarities than differences.

Similarity

Glucophage and Siofor have similar characteristics:

  • the preparations contain the same active ingredient metformin;
  • are prescribed in the therapy of type 2 diabetic pathology;
  • used to reduce body weight;
  • suppress appetite;
  • should not be taken during pregnancy;
  • available in tablet form.

In addition, you must refuse to take both funds a few days before and after the X-ray examination.

What is the difference

The drugs differ in their effect on the body:

  1. Glucophage is addictive to low blood sugar, and a break is required after ingestion to restore body function.
  2. When Siofor is taken, after 3 months, weight loss slows down, but not due to addiction to the drug, but due to the regulation of the metabolic process.
  3. Siofor is able to inhibit the digestive system, and Glucophage, on the contrary, irritates the stomach and intestines less.
  4. Siofor is more expensive than Glucophage.
  5. Siofor has more contraindications due to the greater number of auxiliary components.

Which is cheaper

Siofor's price - from 240 to 430 rubles, Glucophage - from 160 to 340 rubles.

Is it possible to replace Glucophage with Siofor

Replacement of drugs is possible: with the development of renal pathologies, Glucophage is replaced with Siofor, if there are digestive problems caused by the use of Siofor, Glucophage is prescribed.

Which is better - Glucophage or Siofor?

Which of the drugs is more effective is difficult to answer unequivocally. The selection of a suitable drug takes into account the metabolic rate and the perception of the drug by the body.

The main goal of the drugs is the treatment and prevention of diabetes mellitus and the reduction of concomitant excess weight. Both drugs cope with these tasks well and have no analogues in terms of their effectiveness on the body. If you need to reduce blood sugar levels in a short time, then Siofor is better suited.

With diabetes

Both drugs reduce the risk of developing diabetes by 1/3, and with an active lifestyle - by almost half. These are the only drugs that can help prevent diabetes.

After treatment with Siofor, the body gradually regains its ability to independently regulate the amount of glucose in the blood. When taking Glucophage, the glucose concentration is at a constant level and there are no sudden jumps.

When losing weight

Siofor is more suitable for the fight against excess weight, since it:

  • dulls appetite by reducing the release of insulin;
  • reduces cravings for sweets;
  • reduces the amount of cholesterol;
  • slows down the breakdown of carbohydrates, reduces their absorption and conversion into fat;
  • restores and accelerates metabolism;
  • normalizes the production of thyroid hormones.

The use of beans for the diagnosis of type 2 diabetes

During the period of weight loss, you need to follow a low-carb diet. Physical activity should be done daily to accelerate fat burning and eliminate toxins from the body. You cannot take more than 3,000 mg of metformin for quick weight loss. High concentrations of metformin can interfere with kidney function and negatively affect glucose levels.

The opinion of doctors

Mikhail, 48 years old, nutritionist, Voronezh

Most diabetics have a basic problem: it is difficult for them to cope with their appetite while dieting. Metformin-based medications help reduce sugar cravings.

The habit of overeating and eating at night gradually disappears. For my patients, I draw up a dietary plan and prescribe Glucophage, in case of intolerance I replace it with Siofor.

It works for an hour and immediately suppresses appetite by lowering blood glucose levels.

Oksana, 32 years old, endocrinologist, Tomsk

I prescribe Siofor to my patients. It helps to cope well with diabetes and obesity. If there are side reactions in the form of diarrhea and flatulence, then I replace this drug with Glucophage. After a few days, everything goes away. Today Glucophage and Siofor are the only drugs that effectively treat both diabetes and obesity.

Patient reviews about Glukofazh and Siofor

Natalia, 38 years old, Magnitogorsk

I was diagnosed with diabetes mellitus and the drug Siofor was prescribed for treatment. I took it in the dosage prescribed by the doctor, the condition improved, the sugar was kept within normal limits.

And after a while I noticed that I also lost weight. In 1 month I lost 5 kg.

Although the doctor warned that there could be side effects, I only had a slight abdominal discomfort at the beginning of taking the pills. Then within a week everything went away.

Margarita, 33 years old, Krasnodar

The doctor prescribed Siofor, and I began to drink it, 1 tablet in the morning and in the evening. After 10 days, there were problems with the intestines, upset stools, pain in the stomach. The doctor prescribed Glucophage instead. The bowels have recovered, the pains have gone. The drug is excellent, moreover, thanks to it, I have lost 7.5 kg.

Alexey, 53 years old, Kursk

After 50 years, the level of glucose in the blood increased. At first I took Siofor, but I got bloating, nausea, and the urge to vomit. Then the doctor prescribed Glucophage. I also went on a diet prepared by a nutritionist. I hardly observed any side effects while taking the medication. After 3 weeks, I passed the analysis. Glucose recovered, shortness of breath passed, and I lost 4 kg.

A source: https://diabetikum.ru/lechenie/glyukofazh-ili-siofor.html

What is better to take for diabetes siofor or glucophage

There are many medications that are designed to normalize blood glucose levels. Metformin or Siofor, which is better and more effective? A diabetic may have to choose which medication to buy and what the difference is.

It should be noted that the tablets Metformin Teva, Glukofazh, Siofor are included in the group of drugs-biguanides. Moreover, if you pay attention to the composition of the drug, you can see that the main active ingredient is the same substance.

The active substance metformin is a part of many antihyperglycemic drugs. It is an active ingredient from the third generation biguanide group and helps to lower blood glucose levels.

An antidiabetic agent inhibits the process of gluconeogenesis, the transport of electrons in the respiratory chains of mitochondria. Stimulation of glycolysis occurs, cells begin to better absorb glucose, and its absorption by the intestinal walls decreases.

Indications for the use of a medicinal substance?

One of the advantages of the active ingredient is that it does not provoke a sharp decrease in glucose. This is due to the fact that Metformin is not a stimulating substance for the secretion of the hormone insulin.

The main indications for the use of drugs based on metformin are:

  • the presence of metabolic syndrome or manifestations of insulin resistance;
  • as a rule, in the presence of insulin resistance, obesity develops rapidly in patients, thanks to the effects of Metformin and adherence to a special diet, gradual weight loss can be achieved;
  • if there is a violation of glucose tolerance;
  • scleropolycystic ovary develops;
  • non-insulin-dependent diabetes mellitus as monotherapy or as part of complex treatment
  • insulin-dependent diabetes mellitus in conjunction with insulin injections.

When comparing metformin-based tablets with other sugar-reducing drugs, the following main advantages of metformin should be highlighted:

  1. Its effect on reducing insulin resistance in a patient. Metformin hydrochloride can increase the sensitivity of cells and tissues to glucose produced by the pancreas.
  2. Taking the medicine is accompanied by its absorption by the organs of the gastrointestinal tract. Thus, a slowdown in the absorption of glucose by the intestine is achievedꓼ
  3. Promotes inhibition of liver gluconeogenesis, the so-called glucose replacement process.
  4. It helps to reduce appetite, which is especially important for overweight diabetics.
  5. It has a positive effect on cholesterol levels by lowering bad cholesterol and increasing good.

The advantage of drugs based on metformin is also the fact that they help to neutralize the process of fat peroxidation.

Adverse reactions and possible harm from metformin

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  • Despite the number of positive properties of the substance metformin hydrochloride, its incorrect use can bring irreparable harm to the human body.
  • That is why healthy women who are looking for easy ways to lose weight should think about whether it is worth taking such a medicine?
  • The tablet is also actively used as a drug for weight loss.
  • The main adverse reactions that can occur as a result of taking metformin hydrochloride include:
  • the occurrence of various problems with the gastrointestinal tract, especially symptoms such as nausea and vomiting, diarrhea, bloating and soreness of the abdomen,
  • the medicine increases the risk of developing anorexia,
  • a change in taste is possible, which manifests itself in the appearance of an unpleasant taste of metal in the oral cavity,
  • a decrease in the amount of vitamin B, which makes it necessary to additionally take medications with medicinal additives,
  • manifestation of anemia,
  • with a significant overdose, there may be a risk of developing hypoglycemia,
  • problems with the skin, if there is an allergic reaction to the drug taken.

At the same time, Metformin, Siofor or other structural generics can cause the development of lactic acidosis if a significant accumulation of its amount occurs in the body. Such a negative manifestation most often appears with poor kidney performance.

It should be noted that it is forbidden to take a medicinal substance if the following factors are identified:

  1. Acidosis in acute or chronic forms.
  2. Girls during the period of gestation or breastfeeding.
  3. Patients of retirement age, especially after sixty-five years.
  4. Intolerance to the component of the drug, since severe allergies may develop.
  5. If the patient is diagnosed with heart failure.
  6. With a previous myocardial infarction.
  7. If hypoxia occurs.
  8. During dehydration of the body, which can also be caused by various infectious pathologies.
  9. Excessive physical labor.
  10. Liver failure.

In addition, a hypoglycemic agent negatively affects the gastric mucosa.

It is forbidden to take the medicine in the presence of diseases of the organs of the gastrointestinal tract (ulcer).

Is there a difference between medications?

What is the difference between the drugs Metformin, Glyformin, Siofor for diabetes? Is one medicine different from another? Often, patients are forced to make a choice: Glucophage or Siofor, Glucophage or Metformin, Siofor or Metformin, and so on. It should be noted that a significant difference lies only in the name of the medications.

As already indicated above, the substance metformin hydrochloride is used as the main active ingredient in the composition of such medicines. Thus, the effect of taking these drugs should be the same (when using the same dosages). IN

The difference may consist in additional components, which are also included in the tablet formulations. These are various excipients.

When buying, you need to pay attention to their content - the fewer additional components, the better.

In addition, the attending physician may recommend taking a specific medication, depending on the individual characteristics of the patient's body.

For example, Siofor 500 has the following composition:

  • the main component is metformin hydrochloride,
  • excipients - hypromellose, povidone, magnesium stearate, titanium dioxide, macrogol 6000.

The drug Glucophage (or Glucophage Long) contains the following chemical components:

  • active ingredient - metformin hydrochloride,
  • hypromellose, povidone, magnesium stearate are used as additional components.

Thus, if there is a choice between Siofor or Glucophage for type 2 diabetes mellitus, the second option is better suited in terms of chemical composition, with fewer components.

When choosing a medicine, one should also take into account such a factor as the cost of a medicine. Often, foreign counterparts have a price several times higher than our domestic drugs.

As practice shows, the effect of their reception is no different.

To date, Metformin tablets are the most budgetary option among the medical products that contain metformin hydrochloride.

If a diabetic has doubts about anything and does not know whether it is possible to replace one drug with another, you should consult your doctor. A medical specialist will be able to explain the difference between several medical analogs, and also tell why such a drug is suitable for a particular person.

Glucophage or Siofor - what is evidenced by the instructions for use?

Medicines Glukofazh and Siofor are structural analogs.

Thus, the effect of their use should be manifested equally.

Sometimes the attending physician offers his patient a list of analog tablets with the option to purchase one of them.

If such a situation arises, the following factors should be considered:

  1. The medicine should be cheaper.
  2. If possible, have fewer additional components.
  3. Differences may lie in the list of contraindications and side effects.

For comparison, it is better to use the official instructions for the use of medications, and then choose which drug is more suitable.

Metformin, Glucophage 850 differ from Siofor in the following characteristics:

  1. Glucophage 850 has a greater number of adverse reactions manifested. That is why, some consumer reviews indicate that the drug did not suit them.
  2. The comparison shows that there are more contraindications and cases when Siofor cannot be taken (in contrast to Glucophage with Metformin).
  3. The price of Glucophage is slightly higher, in this matter Siofor is better.

It should be noted that if a medical specialist prescribes the use of prolonged-release tablets, then the cost of the drug increases significantly. For example, Glucophage Long will cost about three hundred rubles with a minimum dosage.

The opinion of medical specialists is that such drugs are good at lowering elevated blood sugar levels, neutralizing the manifestation of resistance to the hormone insulin and helping to normalize good cholesterol. Tablets can be replaceable, as a result of which the patient can choose the option that is more optimal for him.

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Metformin - analogues

Metformin hydrochloride appeared on the pharmaceutical market in 1957, and until now this hypoglycemic drug is a recognized leader in the treatment of type 2 diabetes mellitus, including those complicated by obesity. As an active ingredient, metformin increases the sensitivity of cells to insulin. Derivatives of the drug Metformin are natural substances obtained from plants:

  • French lilac;
  • goat rue (goat's rue).

According to modern scientific research, the drug Metformin is also effective in the treatment of certain types of oncology (mainly those associated with diabetes) and fatty liver disease.

How to replace Metformin?

Sometimes patients, believing that the treatment process is taking place without significant results, are interested in how Metformin can be replaced. Let's try to find out what analogs Metformin tablets have and how effective they are in treating diabetes.

Popular substitutes for Metformin

  • Glucophage;
  • Siofor;
  • Metfogamma;
  • Hexal;
  • Formetin.

All of them also contain a similar active substance, from which the logical conclusion follows that the drugs have a similar effect on the body, and, accordingly, have the same indications, contraindications for use and methods of administration.

Siofor, like Metformin, is an oral drug with hypoglycemic effects. Siofor is a product of the German pharmaceutical company BERLIN-CHEMIE. Siofor and Metformin tablets are considered a good alternative to insulin injections, provided that treatment is started on time.

Which is better - Metformin or Glucophage?

Glucophage contains metformin hydrochloride as an active ingredient, and is also taken in type 2 diabetes mellitus as a mono-agent and in complex therapy. A variety of the drug Glucophage-Long provides an extended period of action.

Studies have shown that Glucophage is two times less likely to cause disorders of the digestive system than Metformin. But, if we compare the two pharmaceuticals in terms of price, then the cost of the Glucophage-Long drug is much higher.

Based on the foregoing, it can be concluded that synonymous medicines can replace each other, but this requires the appointment of a specialist. But the lack of the desired effect is most often explained by:

  • violations when taking drugs (regimen, dose or diet);
  • the need to use metformin-containing drugs in combination with a group of drugs that improve their action.

Other Metformin analogues

  1. Below are the means that can successfully replace the drug Metformin.
  2. Vijar
  3. It is a dietary supplement that lowers blood glucose and cholesterol levels, activates the immune system and is considered an excellent means of preventing viral and bacterial infections.
  4. BAA Spirulina
  5. Helps in the fight against diabetes mellitus and other metabolic disorders, as well as overweight.
  6. Glucoberry
  7. Biologically active substance used to reduce the risk of complications from diabetes.
  8. Glucosil
  9. A drug used to correct body functions in type 1 and 2 diabetes mellitus and to optimize metabolic processes.
  10. Guarem
  11. A drug taken for poorly controlled diabetes and obesity, when the transition to insulin therapy is not desirable.
  12. Midona
  13. A drug used for insulin-dependent and non-insulin-dependent diabetes mellitus, metabolic disorders of other substances in the body and severe obesity.

A source: https://diabet.glivec.su/chto-luchshe-prinimat-pri-diabete-siofor-ili-gljukofazh/

What is better for diabetes mellitus: Siofor or Glucophage

Often, patients cannot decide which of the drugs is better for diabetes mellitus - Siofor or Glucophage. It will be easier to figure out which one is better, only by considering the properties of both.

Siofor

This drug is considered one of the most popular in the world, taken for the prevention and treatment of type 2 diabetes. The main component of Siofor is metformin, which is active in restoring the sensitivity of cells to insulin.

In addition, the drug lowers blood cholesterol levels, reducing the risk of cardiovascular disease. But the main qualities, thanks to which the drug is so in demand, is a gradual but noticeable weight loss.

Application of the drug

The diagnosis for the use of this drug is type 2 diabetes mellitus, as well as its prevention and treatment. In most cases, it is prescribed when diet and exercise have failed.

Siofor tablets can be used as a single drug, or in combination with other medicines. In most cases, it is used in combination with drugs that lower glucose levels.

It is allowed to take Siofor both during meals and after it.

An increase in the dose of the drug is permissible, but you should not do it yourself, without first consulting a doctor.

Contraindications to Siofor

There are certain diseases and forms in which the use of the drug is strictly prohibited:

  • type 1 diabetes mellitus;
  • liver disease;
  • coma;
  • minor children;
  • heart failure;
  • lack of insulin production;
  • pregnancy and lactation time;
  • individual intolerance;
  • decreased hemoglobin levels;
  • systematic alcohol consumption.

Siofor for weight loss

This drug is not a weight loss product. But clinical studies and reviews of many patients confirm that Siofor is good for losing weight. The pills dull the feeling of hunger and help speed up the metabolism. This, in turn, leads to the loss of extra pounds.

The effect of the remedy lasts only while it is being taken. After stopping taking Siphora, the patient regains weight. But the drug also has positive aspects.

It has a minimal amount of side effects. The main side effects of taking the drug are diarrhea, bloating and slight rumbling.

The cost of Siphor is much lower than similar funds, which makes it affordable for all segments of the population.

In order to get rid of excess weight, you need to take pills in combination with a low-carb diet and exercise. Taking a large amount of the drug can lead to an overdose, which can be fatal. Therefore, in the hope of losing extra pounds, you should not increase the recommended dose of the drug.

Siofor for type 2 diabetes

The main rules of preventive measures for type 2 diabetes mellitus are maintaining a healthy lifestyle, changing the quality of nutrition and increasing physical activity.

But these rules are followed by a smaller proportion of patients. For most patients, taking the drug is necessary as an additional means for losing weight.

But without dietary nutrition and physical activity, the remedy does not give the expected result.

Glucophage

For diabetics of the second type, Glucophage is considered an analogue of Siofor. In some situations, the action of Glucophage is better, but it also has its negative sides.

The main positive side of the drug is its prolonged action, which allows the drug to act within 10 hours. Metformin from Siofor is released after half an hour.

But there are variants of Gluuofage without prolonging action.

Why Glucophage is considered better than Siofor

  1. Siofor has its own dosage, so it is recommended to take it several times a day. Glucophage is taken once a day.
  2. There are much fewer side effects from taking Glucophage, since it needs to be taken less often.
  3. There are no spikes in blood sugar levels.
  4. The dosage of Glucophage is less, but despite this, it is not inferior to similar drugs in lowering glucose levels.

Glucophage, just like Siofor, is prescribed for type 2 diabetes and leads to weight loss. The slimming effect that appears after taking Glucophage is associated with the restoration of impaired metabolism.

Normalizing sugar levels leads to a decrease in cholesterol, and a constant release of insulin leads to loss of appetite.

Application of Glucophage

Taking Glucophage tablets should be accompanied by a dietary meal. It is necessary to eliminate foods with a high glucose content from the diet and increase foods with a high fiber content. The daily calorie intake should not exceed 1800.

Along with the regulation of nutrition, you need to protect yourself from bad habits, such as smoking and drinking, at least temporarily.

Also, at the time of taking the drug, you need to increase physical activity, this is necessary for better absorption of Glucophage into the stomach walls.

The course of treatment is designed for 20 days of taking the drug, after which a break should be taken to prevent addiction to Glucophage. After two months, you can take a second course of taking the drug.

Contraindications to the drug

  • type 1 diabetes mellitus;
  • kidney disease;
  • pregnancy and lactation period;
  • trauma and postoperative intervention;
  • pathology of the cardiovascular system;
  • individual intolerance to the drug;
  • alcoholism.

Side effects

  1. Headache.
  2. Flatulence.
  3. Diarrhea.
  4. Temperature increase.
  5. Weakness and fatigue.

These symptoms often appear with a self-increase in the dose of the drug or non-compliance with the diet. If side effects from the drug appear, it is necessary to reduce the dosage and seek the advice of a doctor.

Which of the drugs is better - Siofor or Glucophage

These drugs are analog, so it is impossible to say for sure which one is better. It all depends on the individual action on the patient's body.

Given that Glucophage has much more side effects, it is slightly inferior to its counterpart. But Siofor has its negative sides in the form of individual intolerance.

In this case, of course, Glucophage will have clear advantages. If we compare the cost of drugs, then it is practically the same.

Glucophage Long is much more expensive, but this is a new form of the drug, so you need to pay attention to the price.

Despite the fact that the drugs are different, the quality of the effect on a patient with type 2 diabetes is approximately the same.

Glucophage is manufactured in France, and Siofor in Germany, they have completely different packaging and dosage. But despite this, both drugs are based on metformin, therefore, they are almost identical.

A source: https://diabetes.propto.ru/article/chto-luchshe-pri-saharnom-diabete-siofor-ili-glyukofazh

In group II diabetes mellitus (non-insulin dependent), one of two drugs is often prescribed: Siofor or Glucophage. Which one is better and are there any fundamental differences? First you need to consider what each drug is, how to take them, and then compare and determine which is preferable.

Siofor

The drug is indicated for diabetes mellitus of the second group (non-insulin dependent). Good for treating obese people. Especially if physical activity turns out to be ineffective.

Siofor is used not only for the treatment of diabetes, but also for its prevention. In any case, a consultation with a doctor is necessary.

Pharmacological data

The drug is a hypoglycemic agent, made on the basis of the metformin component and belongs to the biguanide group. Thanks to metformin, it lowers blood glucose levels and has a therapeutic effect.

Siofor and Glukofazh - what is better for diabetes mellitus, how to take medications, analogues

During diabetes treatment, the production of glucose by the liver decreases (inhibition of gluconeogenesis). In the gastrointestinal tract, Siofor reduces the ability to absorb glucose. These processes affect the lowering of sugar levels.

The drug also increases the sensitivity of peripheral tissues to glucose, with the result that most of it is absorbed by the muscles and quickly excreted. This is another process that contributes to lowering sucrose levels.

Siofor has an effect on the concentration of cholesterol in the blood, lowering it. Stabilizes or reduces weight, which helps in the fight against obesity. Because of this property, the drug is used as diet pills.

Siofor and Glukofazh - what is better for diabetes mellitus, how to take medications, analogues

Apart from lowering sugar levels, Siofor affects lipid metabolism in cell membranes. It also has a fibrinolytic effect.

Instructions for use

Take Siofor for diabetes orally with mono- or complex treatment. It can be used in conjunction with insulin injections, but it is better to do this with inpatient treatment.

Siofor and Glukofazh - what is better for diabetes mellitus, how to take medications, analogues

You need to consume 2-3 times a day immediately after meals. It is possible and on time, but then the absorption of the drug will be a little slower.

The dosage starts at 500 mg per day, on the fourth day the dose may increase to 3 g per day. Every 14 days, sugar control is carried out and the dosage is changed if necessary. The maximum dose of the drug is 3 g per day.

Side effects and overdose

As such, no overdose was found. But with an excessive increase in the dose, lactic acidosis can develop, it also applies to side effects.

Among the side effects are also distinguished:

  • nausea, vomiting, abdominal pain, metallic taste in the mouth, and loss of appetite;
  • allergy (manifests itself in the form of a skin rash);
  • violation of the assimilation of vitamin B12.

Siofor and Glukofazh - what is better for diabetes mellitus, how to take medications, analogues

If side effects appear, it is recommended to stop using the drug. After a few days, the symptoms will disappear.

Significant contraindications

Siofor is contraindicated in case of intolerance to one of the components and liver and kidney disease. This is due to the fact that Siofor acts primarily on the liver, inhibiting the production of glucose. And for people with renal failure, the drug is contraindicated due to the fact that it is the kidneys that are responsible for its excretion from the body. The latter is difficult in kidney disease.

Other contraindications:

  • acute myocardial infarction;
  • lactic acidosis;
  • alcoholism;
  • many injuries and injuries;
  • infectious diseases;
  • pregnancy and lactation;
  • 2 days before and 2 days after surgery.

Siofor and Glukofazh - what is better for diabetes mellitus, how to take medications, analogues

Glucophage

The drug is indicated for stage II diabetes and problems with excess weight. In the second case, it is prescribed if exercise and diet were ineffective. Therefore, some believe that it can be used for weight loss (you must first consult with your doctor). Glucophage, like Siofor, is used to prevent diabetes mellitus.

The drug is for oral administration. Release form - tablets.

Siofor and Glukofazh - what is better for diabetes mellitus, how to take medications, analogues

The mechanism of action of the drug

The main component in the composition is metformin, it is he who has a hypoglycemic effect. Glucophage, like Siofor, lowers blood sugar and inhibits the production of glucose in the liver. In addition, it increases the sensitivity of muscle fibers that capture and process glucose.

Siofor and Glukofazh - what is better for diabetes mellitus, how to take medications, analogues

Suitable for the prevention of diabetes. When ingested, it affects the sugar level only if it is exceeded. If the glucose level is in order, then Glucophage has no effect on it.

Additionally, the drug has an effect on lipid metabolism. Reduces cholesterol levels.

Glucophage is absorbed in the gastrointestinal tract (gastrointestinal tract), with food intake, assimilation is slower. It is excreted from the body mainly by the kidneys, a smaller part through the stomach.

Siofor and Glukofazh - what is better for diabetes mellitus, how to take medications, analogues

General instruction

The tablets must be drunk whole, not halving or crushing. Initially, a dose of 500 mg is prescribed, the drug is used 2-3 times a day. After two weeks, the glucose level is checked and the dosage changes depending on the changes.

Siofor and Glukofazh - what is better for diabetes mellitus, how to take medications, analogues

The decision to increase / decrease the dose or discontinue the drug should be made by the attending physician. He also prescribes the medicine.

The maximum daily dose of the drug is 3 g. The maximum single dose is 1 g.

Side effects and overdose

In case of an overdose, the development of lactic acidosis is possible. In this case, the use of the drug is canceled. Control of the level of lactate and metformin in the body, as well as treatment of the consequences of an overdose is carried out in a hospital.

In the process of using Glucophage, the following side effects are possible:

  • nausea, vomiting, lack of appetite, abdominal pain, metallic taste in the mouth, flatulence, anorexia;
  • megaloblastic anemia;
  • impaired liver function;
  • allergic reactions (expressed as skin rash, redness, itching);
  • lactic acidosis.

Siofor and Glukofazh - what is better for diabetes mellitus, how to take medications, analogues

When side effects appear, the person taking the medication should refuse it. Symptoms will subside within a few days / a week. If you experience side effects, you should consult your doctor.

Who should not take medication?

Contraindications Glucophage has exactly the same as Siofor. In short, these are:

  • personal intolerance to the components;
  • impaired renal and liver function;
  • alcoholism;
  • lactic acidosis;
  • pregnancy and lactation.

Siofor and Glukofazh - what is better for diabetes mellitus, how to take medications, analogues

What to choose: Siofor or Glucophage?

So, which is better for diabetes mellitus: Siofor or Glucophage? There is no definite answer here.

Siofor and Glukofazh - what is better for diabetes mellitus, how to take medications, analogues

The fact is that these two drugs are very similar to each other. They have one main component, metformin, and are analogous.

Their principle of operation is also the same, as is the effect. The list of contraindications, as seen above, is very similar. Both drugs should not be used for renal failure and other kidney problems, during pregnancy, etc.

Those who take the drugs note that Glucophage has a lower chance of side effects, although if you look at the list of side effects, it is the same for both drugs. According to reviews, Glucophage is less irritating to the walls of the stomach and intestines.

Another plus of Glucophage is that it has a slightly more pronounced effect. As for the price, Siofor is slightly more expensive than its counterpart. There are no other fundamental differences between the drugs.

If you nevertheless choose Siofor or Glucophage, then you can opt for the second drug. But, in general, be guided by the doctor's recommendations and the presence of a certain type in the pharmacy.

The author of the article

Specialized endocrinologist

Which is better - "Siofor" or "Glucophage"? These are analogous drugs with metformin in the composition. This substance is used in the treatment of diabetes mellitus if the diet does not work. With drugs, blood sugar levels are lowered. The doctor may prescribe several medications. But most often, either Glucophage or Siofor is prescribed. Although there are other analogs. They will be given at the end of the article.

which is better siofor or glucophage

Main pharmacological properties

The active substance metformin is the same for these medicines. Thanks to him, it happens:

  • decreased sensitivity of cells to insulin;
  • decreased absorption of glucose in the intestine;
  • improving the sensitivity of cells to glucose.

What is the difference between Siofor and Glucophage? Let's figure it out.

The production of its own insulin is not stimulated by metformin, but only improves the response of the cells. The result is an improvement in carbohydrate metabolism in the body of a diabetic. Thus, the substance in the preparation:

  • reduces appetite - a person simply consumes less food, due to this excess weight is lost;
  • normalizes carbohydrate metabolism;
  • reduces weight;
  • reduces the concentration of sugar in the blood.

glucophage 500

Complications of diabetes are less common with these medications. The risk of heart and vascular diseases is reduced. Diabetics so often suffer from this.

Each drug has its own dosage and duration of action, which is determined by the attending physician. There is a long-acting metformin. This means that the effect of lowering blood glucose levels lasts for a long time. The name of the medicine contains the word "long". Against the background of taking, for example, the drug "Glucophage Long", the level of bilirubin is leveled and protein metabolism is normalized. The prolonged drug is taken only once a day.

When choosing one or another drug, it is necessary to understand that if the active substance is the same for them, then the mechanism of operation will be similar.

People who suffer from diabetes often ask the question: which is better - "Siofor" or "Glucophage"? In this article, we will consider in more detail both the one and the other drug.

All prescriptions of medicines should be carried out by the attending physician. Self-medication is unacceptable. To exclude the occurrence of any adverse reactions from the body, it is necessary:

  • strictly follow the recommended diet;
  • exercise regularly (this can be swimming, running, outdoor games, fitness);
  • take the drug, observing the dosage and all other doctor's prescriptions.

If the attending physician did not name a specific medicine, but gave several names to choose from, then the patient can get acquainted with consumer reviews and buy the most suitable remedy for him.

So, which is better - "Siofor" or "Glucophage"? To answer this question, it is necessary to consider the properties of these drugs.

Siofor analogues

About the medicine "Siofor"

It is the most sought-after drug, according to consumers, for prophylactic purposes for weight control, as well as for the treatment of type 2 diabetes. In the composition of the drug, the active substance metformin, which helps the cells to become sensitive to insulin, that is, is used to prevent insulin resistance. As a result of the intake, the level of cholesterol decreases, and with it the risk of cardiovascular diseases decreases. Weight is gradually and effectively reduced, this is the main advantage of Siofor.

How to apply Siofor?

We will consider analogs later.

Most often, the drug "Siofor" is prescribed for type 2 diabetes mellitus for its treatment and prevention. If a certain set of physical exercises and diet do not bring results, it also makes sense to start taking it.

It can be used alone or in combination with other drugs that affect blood glucose (insulin, sugar-lowering tablets). It is better to take it at the same time with food or immediately after it. The increase in dosage should be monitored by the attending physician. This is confirmed by the instruction for the preparation "Siofor 500".

What contraindications does Siofor have?

This drug should not be taken under the following conditions:

  • Type 1 diabetes mellitus (only if there is no obesity, which is treated with "Siofor").
  • The pancreas does not produce insulin (can occur with type 2).
  • Coma and ketoacidotic coma.
  • Micro- and macroalbuminemia and uria (proteins of globulins and albumin are contained in urine and blood).
  • Liver disease and insufficient detoxification function.
  • Insufficient work of the heart and blood vessels.
  • Shortness of breath.
  • Decreased levels of hemoglobin in the blood.
  • Surgery and Trauma.
  • Excessive alcohol consumption.
  • Pregnancy and breastfeeding.
  • In children under 18 years of age.
  • Individual intolerance to the components of the drug.
  • Taking oral contraceptives, there is a risk of unwanted pregnancy.
  • In old age after 60 years, if they carry out hard work.

    drug glucophage

As you can see from the above, Siofor has a lot of contraindications. Therefore, it must be taken only as directed by the attending physician and with caution.

If side effects occur, you must stop using the medication and immediately consult a doctor.

Application of "Siofor" for weight loss

"Siofor" is not a special drug for weight loss, but reviews confirm that excess weight goes away very quickly while taking pills. Appetite decreases, metabolism accelerates. In a short time, many managed to get rid of several kilograms. This effect persists as long as the drug is taken. As soon as people stop drinking it, weight comes back due to body fat.

Siofor has many advantages over other drugs. The number of side effects is minimal. Among the most common are diarrhea, bloating, and flatulence. The cost of the medication is low, which makes it affordable for everyone.

But it is important to consider some points. A low-carb diet must be followed. This will help you lose weight. In addition, it is necessary to exercise regularly while taking Siofor.

In large quantities, Siofor can be dangerous. This is fraught with lactic acidosis, which can lead to death. Therefore, the dosage should not be exceeded, and if you want to get rid of excess weight, you can quickly go jogging or swimming, for example.

With type 2 diabetes

How to apply Siofor 500? The instruction says that the basic rules for the prevention of diabetes are as follows:

  • healthy lifestyle;
  • correct, well-balanced nutrition;
  • physical activity.

But not all people are ready to follow these recommendations. "Siofor" in these cases can help to get rid of excess weight, which in turn will prevent diabetes. But diet and physical activity must still be present, otherwise the desired results will not be achieved.

which drug is better than glucophage or siofor

About the drug "Glucophage"

This medication can be considered an analogue of Siofor. It is also prescribed for type 2 diabetics. Many consider it more effective, but it also has negative qualities.

Glukofazh has a prolonged action, this is its main advantage. Metformin is released over 10 hours. The action of Siofor stops after half an hour. On sale you can also find the drug "Glucophage", which will not have a prolonged action.

What are the advantages of the drug "Glucophage" in comparison with "Siofor"? More about this below:

  1. Siofor is taken in a certain dosage several times a day. It is enough to drink "Glucophage Long" once a day.
  2. The gastrointestinal tract suffers to a lesser extent, since it is taken less often.
  3. There are no sudden changes in glucose, especially in the morning and at night.
  4. A lower dosage does not affect the effectiveness, glucose is well reduced, as well as when taking Siofor.

Doctors prescribe Glucophage 500 for type 2 diabetes, but weight loss is a pleasant addition.

Why does a person lose weight from these pills?

  1. There is a restoration of impaired lipid metabolism in the body.
  2. There is a much less digestion of carbohydrates, they do not absorb and do not turn into fat deposits.
  3. The concentration of glucose in the blood is normalized, and the amount of cholesterol is reduced.
  4. Decreased appetite due to less release of insulin into the bloodstream. And, accordingly, less food consumption leads to weight loss.

Instructions for the use of "Glucophage"

It is imperative, as when taking Siofor, to follow a diet:

  1. Foods that increase the concentration of glucose are excluded from the diet.
  2. Fast carbohydrates are completely excluded. These are sweets, pastries, potatoes.
  3. Fiber-rich foods are increasing (it is necessary to eat wholemeal bread, fresh vegetables and fruits, as well as legumes).

1700 kcal per day - you need to strive for this indicator. It is also desirable to eradicate bad habits. Alcohol during drug therapy should be minimized. Smoking leads to poor absorption, which means that nutrients are absorbed in a smaller volume. Physical activity is mandatory while using the Glucophage medication. Take pills for 20 days, then a break is shown. After it, you can repeat the course of treatment. This is done to reduce the risk of addiction.

Siofor reception

When is the drug contraindicated?

It is not recommended to use the drug "Glucophage 500" at:

  1. Type 1 diabetes mellitus.
  2. Pregnancy and lactation.
  3. Immediately after surgery or injury.
  4. Diseases of the cardiovascular system.
  5. Kidney disease.
  6. Individual intolerance to the ingredients of the drug.
  7. Chronic alcoholism.

Side effects

Each drug can cause negative reactions in the body. It is important to respect the dosage. Side effects are rare, but in some cases, the following may appear:

  1. Dyspeptic disorders.
  2. Headache.
  3. Flatulence.
  4. Diarrhea.
  5. Increase in body temperature.
  6. Weakness and fatigue.

They happen most often when the recommended dosage is exceeded. In addition, it happens that without a low-carbohydrate diet while taking "Glucophage", side reactions of the body develop, more often from the gastrointestinal tract. It is imperative to cut the dosage in half. A specialist consultation is needed to rule out complications, especially if you have type 2 diabetes.

It's time to determine - which is better: "Siofor" or "Glucophage"?

findings

Since these are similar products with one active ingredient, it is difficult to choose between them. Moreover, the result of treatment depends entirely on the individual characteristics of the organism:

  1. The Glucophage remedy has quite a few side effects, which may be why it is inferior to Siofor.
  2. Siofor has more contraindications.
  3. In case of intolerance to the components of the drug, you can start taking "Glucophage" with prolonged action.
  4. Their price is about the same, however, "Glucophage" is more expensive. Prolonged "Glucophage" costs more than usual, so when choosing the price may matter.
  5. The number of receptions per day does not affect the result.

The drugs are almost identical, so the choice is up to the consumer. What is the price for Glucophage tablets? How much does Siofor cost?

what is the difference between siofor and glucophage

Price

Siofor can be purchased at any pharmacy chain at a price of 250 rubles for 500 mg. The usual "Glucophage" costs from 100 to 300 rubles, "Glucophage Long" from 200 to 600, depending on the region and dosage.

Which drug is better - "Glucophage" or "Siofor"? Reviews confirm that this question is often asked by consumers.

Testimonials

There are a huge number of reviews about these two drugs. Most of them are positive. They act effectively, especially the consumers like medicines with prolonged properties. You do not need to constantly remember to take the pill, just drink it once a day in the morning. Blood sugar decreases, and there are no sharp jumps during the day. It is very comfortable. Side effects are extremely rare, mainly when the dosage is exceeded. Many people like the fact that excess weight is reduced. But this is subject to compliance with the diet and physical activity.

Consider analogues to the drugs "Glucophage" and "Siofor".

What to replace?

There are other analogues for the active substance:

  • "Glyformin".
  • "Metfogamma".
  • "Metformin Richter".
  • "Formetin".

In group II diabetes mellitus (non-insulin dependent), one of two drugs is often prescribed: Siofor or Glucophage.

Which one is better and are there any fundamental differences? First you need to consider what each drug is, how to take them, and then compare and determine which is preferable.

Siofor

The drug is indicated for diabetes mellitus of the second group (non-insulin dependent). Good for treating obese people. Especially if physical activity turns out to be ineffective.

Siofor is used not only for the treatment of diabetes, but also for its prevention. In any case, a consultation with a doctor is necessary.

Pharmacological data

The drug is a hypoglycemic agent, made on the basis of the metformin component and belongs to the biguanide group. Thanks to metformin, it lowers blood glucose levels and has a therapeutic effect.

Glucophage or Siofor: which is better?

During diabetes treatment, the production of glucose by the liver decreases (inhibition of gluconeogenesis). In the gastrointestinal tract, Siofor reduces the ability to absorb glucose. These processes affect the lowering of sugar levels.

The drug also increases the sensitivity of peripheral tissues to glucose, with the result that most of it is absorbed by the muscles and quickly excreted. This is another process that contributes to lowering sucrose levels.

Siofor has an effect on the concentration of cholesterol in the blood, lowering it. Stabilizes or reduces weight, which helps in the fight against obesity. Because of this property, the drug is used as diet pills.

Glucophage or Siofor: which is better?

Apart from lowering sugar levels, Siofor affects lipid metabolism in cell membranes. It also has a fibrinolytic effect.

Instructions for use

Take Siofor for diabetes orally with mono- or complex treatment. It can be used in conjunction with insulin injections, but it is better to do this with inpatient treatment.

Glucophage or Siofor: which is better?

You need to consume 2-3 times a day immediately after meals. It is possible and on time, but then the absorption of the drug will be a little slower.

The dosage starts at 500 mg per day, on the fourth day the dose may increase to 3 g per day. Every 14 days, sugar control is carried out and the dosage is changed if necessary. The maximum dose of the drug is 3 g per day.

Side effects and overdose

As such, no overdose was found. But with an excessive increase in the dose, lactic acidosis can develop, it also applies to side effects.

Among the side effects are also distinguished:

  • nausea, vomiting, abdominal pain, metallic taste in the mouth, and loss of appetite;
  • allergy (manifests itself in the form of a skin rash);
  • violation of the assimilation of vitamin B12.

Glucophage or Siofor: which is better?

If side effects appear, it is recommended to stop using the drug. After a few days, the symptoms will disappear.

Significant contraindications

Siofor is contraindicated in case of intolerance to one of the components and liver and kidney disease. This is due to the fact that Siofor acts primarily on the liver, inhibiting the production of glucose. And for people with renal failure, the drug is contraindicated due to the fact that it is the kidneys that are responsible for its excretion from the body. The latter is difficult in kidney disease.

Other contraindications:

  • acute myocardial infarction;
  • lactic acidosis;
  • alcoholism;
  • many injuries and injuries;
  • infectious diseases;
  • pregnancy and lactation;
  • 2 days before and 2 days after surgery.

Glucophage or Siofor: which is better?

Glucophage

The drug is indicated for stage II diabetes and problems with excess weight. In the second case, it is prescribed if exercise and diet were ineffective. Therefore, some believe that it can be used for weight loss (you must first consult with your doctor). Glucophage, like Siofor, is used to prevent diabetes mellitus.

The drug is for oral administration. Release form - tablets.

Hypertonium will reduce blood pressure to the age norm without chemistry and side effects! More details Glucophage or Siofor: which is better?

The mechanism of action of the drug

The main component in the composition is metformin, it is he who has a hypoglycemic effect. Glucophage, like Siofor, lowers blood sugar and inhibits the production of glucose in the liver. In addition, it increases the sensitivity of muscle fibers that capture and process glucose.

Glucophage or Siofor: which is better?

Suitable for the prevention of diabetes. When ingested, it affects the sugar level only if it is exceeded. If the glucose level is in order, then Glucophage has no effect on it.

Additionally, the drug has an effect on lipid metabolism. Reduces cholesterol levels.

Glucophage is absorbed in the gastrointestinal tract (gastrointestinal tract), with food intake, assimilation is slower. It is excreted from the body mainly by the kidneys, a smaller part through the stomach.

Glucophage or Siofor: which is better?

General instruction

The tablets must be drunk whole, not halving or crushing. Initially, a dose of 500 mg is prescribed, the drug is used 2-3 times a day. After two weeks, the glucose level is checked and the dosage changes depending on the changes.

The decision to increase / decrease the dose or discontinue the drug should be made by the attending physician. He also prescribes the medicine.

The maximum daily dose of the drug is 3 g. The maximum single dose is 1 g.

Side effects and overdose

In case of an overdose, the development of lactic acidosis is possible. In this case, the use of the drug is canceled. Control of the level of lactate and metformin in the body, as well as treatment of the consequences of an overdose is carried out in a hospital.

In the process of using Glucophage, the following side effects are possible:

  • nausea, vomiting, lack of appetite, abdominal pain, metallic taste in the mouth, flatulence, anorexia;
  • megaloblastic anemia;
  • impaired liver function;
  • allergic reactions (expressed as skin rash, redness, itching);
  • lactic acidosis.

When side effects appear, the person taking the medication should refuse it. Symptoms will subside within a few days / a week. If you experience side effects, you should consult your doctor.

Who should not take medication?

Contraindications Glucophage has exactly the same as Siofor. In short, these are:

  • personal intolerance to the components;
  • impaired renal and liver function;
  • alcoholism;
  • lactic acidosis;
  • pregnancy and lactation.

What to choose: Siofor or Glucophage?

So, which is better for diabetes mellitus: Siofor or Glucophage? There is no definite answer here.

The fact is that these two drugs are very similar to each other. They have one main component, metformin, and are analogous.

Their principle of operation is also the same, as is the effect. The list of contraindications, as seen above, is very similar. Both drugs should not be used for renal failure and other kidney problems, during pregnancy, etc.

Those who take the drugs note that Glucophage has a lower chance of side effects, although if you look at the list of side effects, it is the same for both drugs. According to reviews, Glucophage is less irritating to the walls of the stomach and intestines.

Another plus of Glucophage is that it has a slightly more pronounced effect. As for the price, Siofor is slightly more expensive than its counterpart. There are no other fundamental differences between the drugs.

If you nevertheless choose Siofor or Glucophage, then you can opt for the second drug. But, in general, be guided by the doctor's recommendations and the presence of a certain type in the pharmacy.

A source: https://AboutDiabetes.ru/siofor-i-glyukofazh-pri-diabete.html

Siofor or glucophage - which is better for losing weight and what is the difference

If a person cannot control their appetite during diet therapy, then the doctor may prescribe an appetite suppressant medication. For such purposes, Siofor or Glucophage are usually prescribed. Medicines are very similar in composition and therapeutic effect, but there are some differences.

But which medicine is better? How to drink these drugs to treat obesity correctly? And what is the effectiveness of therapy with Glucophage and Siofor? Below we will look at these issues.

Why are medicines often compared?

Glucophage or Siofor: which is better?

Glucophage and Siofor are two drugs that are very often used to treat obesity in humans. Initially, these drugs were only used to treat type 2 diabetes, but more recently, these drugs have become widely used to treat obesity. The fact is that these drugs contain special components that can suppress appetite, so taking these drugs can be very useful in the treatment of obesity.

In their composition and therapeutic properties, these drugs are very similar to each other. However, there are certain differences between them, so it is not surprising that these drugs are constantly being compared. Below we will consider the therapeutic features of each drug, and then we will find out which of these drugs is the most effective.

What is Siofor?

Siofor is a broad-spectrum medicine. It is most commonly used to treat type 2 diabetes.

The drug does not completely cure the disease, but only temporarily restores the sensitivity of cells, so a person with diabetes should take Siofor throughout his life.

When used, the main active ingredient is released almost immediately, and the so-called prolonged effect is absent.

It can also be used to treat other disorders. Studies show that long-term use of Siofor gradually removes harmful cholesterol from the body, so this medicine can be used to treat heart disease that appeared against the background of an increase in cholesterol concentration. Also pills can be used for weight loss.

In the body, the cycle "hunger-satiety" directly depends on the concentration of glucose. If there is too much of it, then the person will experience an acute feeling of hunger. At the same time, carbohydrate metabolism in the body is arranged in such a way that a person still feels hunger for a rather long time during a meal, which often leads to overeating.

Overeating gives your body extra calories that will be converted into fat, which will lead to weight gain. When taken, the sugar concentration is automatically reduced, leading to a feeling of fullness. Due to this, it becomes easier for a person to control food intake, and the total amount of food decreases.

Reducing the calorie content of food leads to increased metabolism and burning of subcutaneous fat, which leads to weight loss.

Be sure to read: All the pros and cons of fat burning patches

Glucophage or Siofor: which is better?

Siofor is available in tablet form. The dosage and method of administration of the drug depends on many parameters, but most often this medicine is drunk 1-2 tablets 3 times a day before meals.

This technique is needed in order to suppress appetite in advance.

In this case, Siofor is prescribed quite often in combination with other antihyperglycemic drugs, since Siofor is well combined with many substances.

Studies show that with the help of Siofor, you can lose 1-3 kg per week if you follow the dosage rules.

It should be understood that Siofor itself does not destroy fat, but only reduces a person's appetite, which allows you to create a calorie deficit in the body, which ultimately leads to weight loss. Taking the drug makes sense only if drug therapy is combined with diet therapy and sports activities, and in case of violation of nutritional rules, the effectiveness of therapy will be rather low.

The drug has no side effects if the rules of admission are followed, however, in case of an overdose, disorders such as nausea, vomiting, dizziness, headache, abdominal pain, and so on may occur. In case of an overdose, you must urgently stop taking the drug and consult a doctor for advice (in case of acute poisoning, you can call an ambulance). There are also diseases in which to drink

Siofor is contraindicated:

  • Diseases of the liver and kidneys;
  • Age under 16;
  • Various disorders in which the production of insulin is completely or partially impaired (for example, type 1 diabetes);
  • Pregnancy and lactation;
  • Poor immunity and / or low hemoglobin in the blood;
  • Alcoholism;
  • Heart failure.

Glucophage or Siofor: which is better? Glucophage or Siofor: which is better? Glucophage or Siofor: which is better?

What is Glucophage?

Glucophage is also a metformin-based drug that is also used to treat type 2 diabetes. This drug can also be used to treat certain other disorders, such as obesity.

The main distinguishing feature of Glucophage is the fact that this drug contains a large number of excipients.

Due to this, the so-called prolonged effect is achieved - after taking metformin, it is not released immediately (as in the case of the same Siofor), but gradually over 10-12 hours.

Therefore, Glucophage can be drunk less often. Most often, Glucophage is prescribed for the treatment of type 2 diabetes, but this medicine can also be used to treat obesity. Studies show that with the help of Glucophage, you can also lose about 1-3 kg per week.

Since Glucophage has a prolonged effect, it can be drunk 1 tablet 2 times a day, regardless of the meal time.

However, you need to drink the medicine every 12 hours, since the prolonged effect disappears over time, therefore, if the rules of admission are violated, the concentration of sugar in a person may increase, which will lead to increased appetite.

Glucophage or Siofor: which is better?

Otherwise, Glucophage is very similar to all other metformin-based drugs.

To treat obesity, you need not only to drink Glucophage, but also to adhere to a healthy lifestyle, since otherwise the effectiveness of therapy will be very low.

Glucophage has no side effects if the dosage rules are followed and works well with other drugs to lower sugar. However, this medication is contraindicated in the following cases:

  • Type 1 diabetes and all other diseases in which there is a violation of insulin synthesis;
  • Diseases of the kidneys and liver;
  • Diseases of the cardiovascular system;
  • Alcoholism;
  • Pregnancy and lactation;
  • Age under 16.

Which medicine is best?

As you can see, the drugs are very similar to each other both in composition and in the therapeutic effect on the body.

They are used to treat type 2 diabetes, but because of their potential to lower blood sugar levels, these drugs can be used as appetite suppressants, which can be useful in treating obesity.

The effectiveness of the drugs is the same - with their help, you can lose weight by 1-3 kg per week, if you eat right, play sports and do not have bad habits. Both drugs have the same contraindications, side effects, and compatibility with other drugs.

However, in practice, doctors most often give preference to Glucophage. And that's why:

In the treatment of obesity, it is very important to reduce a person's appetite, since many people stop eating dietary foods due to the fact that they remain hungry after eating a dietary meal. Glucophage or Siofor: which is better?

  • To cope with appetite, a doctor may prescribe medications to lower blood sugar, as they can dull hunger, allowing a person to control their diet.
  • At the same time, it is important to understand that Glucophage, due to additional components, has a prolonged effect, and appetite decreases by 10-12 hours after taking the medication.
  • Siofor is deprived of this advantage, which reduces appetite only immediately after taking it, and after 20-30 minutes the effect of suppressing appetite disappears.
  • Therefore, it is much easier for a person to drink Glucophage 2 times a day, regardless of mealtime, than to drink Siofor several times right before meals.
  • That is why Glucophage, on average, is prescribed more often than Siofor. However, it should be understood that Siofor is also an excellent medicine for suppressing appetite - it is just not very convenient to drink it, however, if the rules of admission are followed, the therapeutic effect will be absolutely the same.

Siofor or Glucophage - what do doctors and patients think?

Let's now find out what ordinary patients and experienced doctors think about the use of Siofor and Glucophage.

Anton Verbitsky, nutritionist

“If a person ate a lot, and then suddenly went on a diet, then it will be very difficult for him. At the same time, it will be difficult for him even in the case of diets that involve a transitional period, when a person can eat his usual dishes.

The main problem lies not so much in the diet (after all, in most cases, making a dietary plan is actually not that difficult), as in the problem of high appetite, since in the case of eating dietary products, it is very difficult for a person to get enough. Fortunately, there are a large number of appetite suppressants available today.

I usually prescribe Glucophage to my patients, since it works for 12 hours, so a person needs to eat one tablet in the morning and one tablet in the evening to cope with their appetite.

However, in the case of very severe obesity, I can prescribe an additional drink of 1 tablet of Siofor, which does not have a prolonged effect, but which immediately reduces the concentration of sugar in the body, which will allow a severely obese person to cope with his appetite. "

Glucophage or Siofor: which is better?

Antonina Petrova, pensioner

“At the age of 70, I started having problems with blood sugar. The excess sugar also made me overweight. The doctor first prescribed Siofor so that I would drink 1 tablet before each meal. In 2 weeks I lost about 5 kg.

However, I was very uncomfortable drinking this medicine before every meal - and I told the doctor about it. The doctor, having thought, prescribed me a drug called Glucophage instead of Siofor. I drank it for also 2 weeks in the morning after waking up and in the evening before dinner. And during this time I also lost 5 kg.

It seems to me that the therapeutic effect of these drugs is the same, but Glucophage is still more convenient to drink. "

Petr Alekseev, worker

“After being transferred to another workshop, my physical activity decreased. Because of this, I began to appear overweight. At first I tried to adjust the diet myself, but nothing good came of it. Then I consulted a dietitian.

He drew up a dietary plan for me, with the help of which I should lose weight by about 8-9 kg per month. However, the dietary restrictions were so severe that I could not sit on this diet for long. When the doctor found out that I had quit the diet, he prescribed Glucophage to me to weaken my appetite. And you know - it helped.

Drinking this medicine is very simple, and its effect appears already after 1-2 hours after taking. Thanks a lot to the doctor. "

Conclusion

Let's summarize. Glucophage and Siofor have a very similar composition, so these drugs have almost the same therapeutic effect.

However, Glucophage has a prolonged effect, while Siofor is devoid of this effect, therefore Glucophage is prescribed more often on average. It should be understood that in all other respects these drugs are very similar.

They are good at suppressing appetite, which is why they are also used to treat excess weight.

With the help of tablets, you can lose weight by 1-3 kg per week if you follow the dosage rules. These medicines are well absorbed, but they are contraindicated in some diseases and during pregnancy.

A source: https://pohudete.ru/siofor-ili-glyukofazh-chto-luchshe.html

How Siofor differs from Glucophage - which is more effective in diabetes

Glucophage or Siofor: which is better?

  • Most often, with Most often, with type 2 diabetes, doctors recommend using Glucophage and Siofor.
  • Both drugs are quite effective, so patients cannot choose which one is better.
  • It is necessary to find out what medicines are similar and what is the difference between Siofor and Glucophage.

The main difference between drugs

To understand which is better than Glucophage or Siofor, it is recommended to learn more about the differences between the drugs. The main differences lie in the way the drugs are used.

Use with a lack of insulin production Can not use Can be applied
Application frequency Several times a day Once a day (Glucophage long)
Contraindications and side effects More contraindications More side effects

In addition, the drugs are different in cost (Siofor is slightly more expensive). Glucophage is an analogue of Siofor, based on one active ingredient.

About glucophage

The medicine Glucophage is available in the form of tablets. The active ingredient is metformin hydrochloride. It affects glycogen synthase, insulin is produced.

Glucophage long (analogue of Glucophage) is especially popular among diabetics, it works for a longer time. The active ingredient metformin is released from the tablet for longer (about 10 hours).

They drink a pill once a day (preferably in the evening), this contributes to a lesser manifestation of side effects from the gastrointestinal tract.

Nevertheless, the drug affects glucose levels no worse than Siofor.

Glucophage or Siofor: which is better?

In addition, the drugs are different in cost (Siofor is slightly more expensive). Glucophage is an analogue of Siofor, based on one active ingredient.

About glucophage

The medicine Glucophage is available in the form of tablets. The active ingredient is metformin hydrochloride. It affects glycogen synthase, insulin is produced.

Glucophage long (analogue of Glucophage) is especially popular among diabetics, it works for a longer time. The active ingredient metformin is released from the tablet for longer (about 10 hours).

They drink a pill once a day (preferably in the evening), this contributes to a lesser manifestation of side effects from the gastrointestinal tract.

Nevertheless, the drug affects glucose levels no worse than Siofor.

Glucophage or Siofor: which is better?

In addition to normalizing blood sugar levels, Glucophage helps fight obesity. When a patient undergoes a course of treatment, lipid metabolism is restored, carbohydrates are less broken down and transformed into fat deposits. The release of insulin decreases, the appetite decreases.

It is important to stick to your diet while taking the medicine. It is allowed to consume no more than 1800 kcal per day. It is also recommended to get rid of bad habits, exercise.

The course of treatment is 20 days (2-3 times a day, one tablet one hour before a meal), then a break is taken for 2 months and the therapy is repeated. Breaks are given to avoid addiction.

Before starting therapy, it is advisable to familiarize yourself with the contraindications that are indicated in the instructions, and possible side effects.

Price - from 122 rubles, depends on the number of tablets and the concentration of the active substance.

About Siophorus

Release form - tablets. The active ingredient is metformin hydrochloride. Due to the use of the drug, the postprandial and basal sugar concentration decreases. Does not affect insulin production, so hypoglycemia does not develop.

Glucophage or Siofor: which is better?

The active ingredient inhibits glycogenolysis and gluconeogenesis, less glucose is produced in the liver. Intracellular production of glucogen is stimulated, lipid metabolism is normalized. Siofor affects the sensitivity of cells to insulin, insulin resistance is prevented.

It is often recommended in the presence of excess weight, as an independent remedy or together with insulin, when a special diet and physical activity did not give the desired result.

To avoid the development of lactic acidosis, it is recommended to exclude the use of alcoholic beverages. If a diabetic is indicated for surgery using general anesthesia, it is necessary to stop taking Siofor and continue using it 48 hours after surgery.

Simultaneously with Siofor, medications can be prescribed to lower blood glucose. Thus, the intensity of glucose absorption increases and its concentration in the blood decreases. In type 2 diabetes, insulin therapy is sometimes prescribed, in which case the patient's well-being becomes much better.

Glucophage or Siofor: which is better?

In some cases, it is used as an independent agent, while there is no need to use other drugs. Physical activity and diet must also be followed.

The dosage of the drug is calculated by an individually qualified specialist, taking into account the individual characteristics of the patient. The effect of the tablets appears within 30 minutes after use. Average cost from 244 rubles.

The use of the drug helps to reduce cholesterol levels, excess weight, and prevent cardiovascular diseases. After stopping the use of Siofor, excess weight is gained again.

Similarities

These drugs have a lot in common. The active ingredient is the same - metformin. Diabetic complications (including cardiovascular pathologies, which are common among diabetics) are less common during treatment.

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Glucophage or Siofor: which is better?

Both medicines are used to treat and prevent type 2 diabetes, to combat excess pounds, and to suppress appetite. For weight correction, Glucophage Long or Siofor is used by healthy people. While the treatment lasts, the effect is visible, but after the cancellation of taking the pills, the weight returns again. In this case, doctors recommend diet and exercise.

Both medicines are strictly forbidden to take during pregnancy. Also, when taken simultaneously with contraceptives, the effectiveness of all medicines is mutually reduced and the load on the kidneys increases.

The opinion of doctors

Reviews of experts regarding what is better Glucophage or Siofor are ambiguous. Siofor is not addictive, but the dosage is selected individually for each patient. For people who do not suffer from diabetes, the drug really helps to reduce weight, the body begins to regulate metabolism. Glucophage has specific dosage instructions.

Glucophage or Siofor: which is better?

Doctors note that both drugs have a positive effect on the body of a diabetic and are quite effective. If Siofor and Glucophage lead to indigestion, doctors recommend Glucophage Long. Taking this drug does not cause spikes in glucose. If the patient needs a quick result or a state of prediabetes, Siofor is prescribed.

Reviews of diabetics

Patients claim that when Siofor is consumed, appetite decreases. The medicine does not "pass" sweet, fatty and other unhealthy foods into the body; side effects appear in the form of nausea and vomiting. Due to this, weight is reduced. It is also believed that for a quick effect, it is better to use Siofor, if time permits - Glucophage is preferred.

Glucophage or Siofor: which is better?

Patients prefer glucophage due to its efficiency and low cost. It is noted that the drug acts more gently. One of the main advantages of the drug is a decrease in appetite and a decrease in cravings for sweets.

Thus, drugs based on metformin have a similar effect on the body, lead to the same results. To make a choice in favor of one medicine, it is recommended that you familiarize yourself with all contraindications, consult with your doctor. Diabetics must remember that for best results, the tablets must be combined with proper diet and physical activity.

A source: https://diabeto.ru/preparaty/chem-siofor-otlichaetsya-ot-glyukofazha/

Glucophage or siofor: which is better and what is the difference (difference between compositions, doctors' reviews)

With type 2 diabetes, doctors often prescribe drugs such as Glucophage or Siofor. They both show efficacy in this condition. Thanks to these medications, cells become more sensitive to the effects of insulin. Such drugs have advantages and disadvantages.

Characteristics of Glucophage

This is a drug that has a hypoglycemic effect. Release form - tablets, the active ingredient of which is metformin hydrochloride. It activates the production of insulin by affecting glycogen synthase, and also has a beneficial effect on lipid metabolism, reducing the concentration of cholesterol and lipoproteins.

Glucophage or Siofor: which is better?

With type 2 diabetes, doctors often prescribe drugs such as Glucophage or Siofor.

In the presence of obesity in a patient, the use of the drug leads to an effective decrease in body weight. It is prescribed for the prevention of type 2 diabetes in patients who have a predisposition to its development. The main component does not affect the production of insulin by the cells of the pancreas, so there is no risk of hypoglycemia.

Glucophage is prescribed for type 2 diabetes, especially for obese patients, if physical activity and diet have been ineffective. You can also use it with other drugs with hypoglycemic properties, or with insulin.

Contraindications:

  • renal / hepatic impairment;
  • diabetic ketoacidosis, precoma, coma;
  • severe infectious diseases, dehydration, shock;
  • diseases of the cardiovascular system, acute myocardial infarction, respiratory failure;
  • type 1 diabetes mellitus;
  • adherence to a low-calorie diet;
  • chronic alcoholism;
  • acute ethanol poisoning;
  • lactic acidosis;
  • surgical intervention, after which insulin therapy is prescribed;
  • pregnancy;
  • excessive sensitivity to components.

In addition, it is not prescribed 2 days before and after the implementation of a radioisotope or X-ray examination, in which an iodine-containing contrast was used.

Adverse reactions include:

  • nausea, vomiting, diarrhea, loss of appetite, abdominal pain;
  • violation of taste;
  • lactic acidosis;
  • hepatitis;
  • rash, itching.

The simultaneous reception of Glucophage with other hypoglycemic agents can cause a decrease in concentration, so you need to drive a car and complex mechanisms with caution.

Analogs include: Glucophage Long, Bagomet, Metospanin, Metadien, Langerin, Metformin, Glyformin. If there is a need for prolonged action, it is recommended to use Glucophage Long.

Siofor's characteristic

It is a drug that helps lower blood glucose levels. Its main component is metformin. It is made in the form of tablets. The drug effectively lowers postprandial and basal sugar concentration. It does not cause hypoglycemia because it does not affect insulin production.

Metformin inhibits glycogenolysis and gluconeogenesis, as a result of which the production of glucose in the liver decreases and its absorption improves. Thanks to the action of the main component on glycogen synthetase, intracellular glycogen production is stimulated. The drug normalizes impaired lipid metabolism. Siofor reduces the absorption of sugar in the intestine by 12%.

A medication is indicated for patients with type 2 diabetes mellitus if diet and exercise have not brought the desired effect. It is especially recommended for overweight patients. The drug is prescribed both as a single drug and in combination with insulin or other diabetes medications.

Glucophage or Siofor: which is better?

Siofor is a drug that helps lower blood glucose levels.

Contraindications include:

  • diabetic ketoacidosis and precom;
  • renal / hepatic impairment;
  • lactic acidosis;
  • type 1 diabetes;
  • recent myocardial infarction, heart failure;
  • a state of shock, respiratory failure;
  • impaired renal function;
  • severe infectious diseases, dehydration;
  • the introduction of a contrast agent containing iodine;
  • adhering to a diet that consumes foods low in calories;
  • pregnancy and lactation;
  • individual intolerance to the components of the medication;
  • age up to 10 years.

During Siofor therapy, alcohol consumption should be excluded, because this can lead to the development of lactic acidosis - a severe pathology that occurs when lactic acid accumulates in the bloodstream.

Adverse reactions occur infrequently. These include:

  • nausea, vomiting, decreased appetite, diarrhea, abdominal pain, metallic taste in the mouth;
  • hepatitis, increased activity of liver enzymes;
  • hyperemia, urticaria, pruritus;
  • violation of taste;
  • lactic acidosis.

Glucophage or Siofor: which is better?

While taking Siofor, a side effect in the form of nausea may appear.

2 days before the operation, during which general anesthesia, epidural or spinal anesthesia will be used, it is necessary to stop taking pills. Their use is resumed 48 hours after the surgery. To ensure a stable healing effect, Siofor should be combined with daily exercise and diet.

Analogs of the drug include: Glucophage, Metformin, Glyformin, Diaformin, Bagomet, Formetin.

The drugs include metformin. They are prescribed for type 2 diabetes in order to normalize the patient's condition. Medicines are produced in the form of tablets. They have the same indications for use and side effects.

Glucophage or Siofor: which is better?

Glucophage is available in tablet form.

What is the difference

Medicines have slightly different restrictions on their use. Siofor cannot be used if there is insufficient insulin production in the body, but Glucophage is possible. The first drug needs to be used several times a day, and the second one - once a day. They also differ in price.

Which is cheaper

Siofor's price - 330 rubles, Glucophage - 280 rubles.

Which is better - Glucophage or Siofor

When choosing between drugs, the doctor takes into account many factors. Glucophage is prescribed more often, because it does not irritate the intestines and stomach as much.

With diabetes

Taking Siofor does not lead to addiction to lowering blood sugar, and when using Glucophage, there are no sharp jumps in blood glucose levels.

Glucophage or Siofor: which is better?

Taking Siofor does not lead to an addictive lowering of blood sugar.

Siofor effectively reduces weight because suppresses appetite and speeds up metabolism. As a result, a diabetic patient can lose several pounds. But this result is observed only while taking the medication. After its cancellation, the weight quickly regains.

Effectively reduces weight and Glucophage. With the help of the drug, the disturbed lipid metabolism is restored, carbohydrates are less broken down and absorbed. Decreased insulin release leads to decreased appetite. Cancellation of the drug does not lead to rapid weight gain.

  1. Siofor and Glucophage for diabetes and weight loss
  2. Metformin interesting facts
  3. Which of the preparations Siofor or Glucophage is better for diabetics?

Reviews of doctors

Karina, endocrinologist, Tomsk: “Glucophage is prescribed for diabetes and obesity. It helps to effectively get rid of excess weight without causing harm to health, it is good for lowering blood sugar. Some patients may have diarrhea while taking the drug. "

Lyudmila, endocrinologist: “I often prescribe Siofor to my patients with type 2 diabetes, conditions of prediabetes. For many years of practice, he proved his effectiveness. Sometimes flatulence and abdominal discomfort may develop. These side effects go away after a while. "

Patient reviews about Glukofazh and Siofor

Marina, 56 years old, Oryol: “I have been suffering from diabetes for a long time. I have tried many different drugs that are designed to lower blood glucose. At first, they helped, but after getting used to it, they became ineffective. A year ago, the doctor prescribed Glucophage. Taking the medication helps to keep the sugar level in the norm, and no addiction has arisen during this time. "

Olga, 44 years old, Inza: “Siofor was appointed by an endocrinologist several years ago. The result appeared after 6 months. My blood sugar levels returned to normal and my weight decreased slightly. At first, there was such a side effect as diarrhea, which disappeared after the body got used to the drug. "

A source: https://SayDiabetu.net/lechenie/tradicionnaya-medicina/drygie-lekarstva/glyukofazh-ili-siofor/

Which is better: Siofor or Glucophage for diabetes? Slimming?

Glucophage or Siofor: which is better?

These drugs are widely used to correct type 2 diabetes.

This variant of the disease develops when insulin is poorly absorbed by cells and is unable to exert its hypoglycemic effect.

Glucophage and Siofor contain the same active ingredient, the only difference is in the manufacturer. Siofor is produced by the well-known German pharmaceutical company Berlin-Chemie, Glucophage is by the French manufacturer Merck Sante.

Glucophage and Siofor: what's the difference?

Pharmacological properties

Both drugs contain the active ingredient metformin, therefore they have common indications, contraindications and mechanism of action.

Metformin increases the sensitivity of cells to the insulin produced by the pancreas, under the influence of which they begin to actively absorb and process glucose.

In addition, metformin inhibits the production of glucose by the liver and interferes with its absorption in the stomach and intestines.

Indications

  • type 2 diabetes mellitus, especially with increased body weight and low efficiency of diet and exercise;
  • prevention of diabetes with an increased risk of its development.

Contraindications

  • hypersensitivity to drugs;
  • coma (depression of consciousness) and the preceding borderline state - precoma - against the background of decompensation of diabetes mellitus;
  • severe disorder of the functioning of the liver or kidneys;
  • conditions and procedures that dramatically increase the load on the kidneys (examinations with contrast, severe infectious process, acute period of extensive trauma, dehydration);
  • oxygen starvation in tissues in acute and chronic diseases or conditions: respiratory or heart failure, shock, severe anemia, decreased cardiac output;
  • previous lactic acidosis (an increase in the concentration of lactic acid in the plasma, which can cause coma);
  • alcohol intoxication;
  • a diet with a daily calorie intake of less than 1000 kcal;
  • the period of pregnancy and breastfeeding;
  • planned surgical intervention;
  • the child's age is less than 10 years.

Side effects

  • nausea, vomiting;
  • suppression of appetite;
  • violation of taste perception, "metallic" taste on the tongue;
  • diarrhea;
  • pain or discomfort in the abdomen;
  • skin allergies;
  • lactic acidosis;
  • decreased absorption of vitamin B12, which can subsequently cause anemia;
  • liver damage.

Release form and price

Siofor

  • tablets of 0.5 g, 60 pcs. - 265 rubles;
  • tab. 0.85 g each, 60 pcs. - 272 p.;
  • tab. 1 g, 60 pcs. - 391 p.

Glucophage

  • tablets of 0.5 g, 60 pcs. - 176 rubles;
  • tab. 0.85 g each, 60 pcs. - 221 rubles;
  • tab. 0.1 g each, 60 pcs. - 334 rubles;
  • tablets "Long", 0.5 g, 60 pcs. - 445 rubles;
  • tab. "Long" 0.75 g each, 60 pcs. - 541 p.;
  • tab. "Long", 0.1 g, 60 pcs. - 740 p.

Which is better: Siofor or Glucophage?

It cannot be reliably said which works better for diabetes, Glucophage or Siofor. The effectiveness and frequency of adverse reactions in drugs are comparable and depend mainly on the individual characteristics of the patient's body. Siofor's price is slightly higher than that of Glucophage, but the difference rarely exceeds 50 rubles.

In reviews of these drugs, many patients give priority to Glucophage due to the availability of a more convenient tablet form with prolonged action, as well as the ability to purchase a smaller package (30 tablets), which is needed during the selection of therapy.

Glucophage or Siofor: which is better for losing weight

In recent years, these drugs have gained popularity among overweight people, as one of their properties is the ability to reduce body weight. With regard to weight normalization, it is also impossible to say for sure which drug is more effective. You can choose any of them, it is only important to follow the general rules for their use.

Read more: Zoloft: 50 mg and 100 mg tablets

With ordinary alimentary obesity (associated with malnutrition), Siofor's intake, as well as the use of Glucophage, are not shown.

They are prescribed exclusively for metabolic obesity, which is associated with a "breakdown" in metabolic processes.

This condition is also accompanied by increased serum cholesterol, hypertension, PCOS (polycystic ovary syndrome) and menstrual irregularities in women.

The use of both Siofor and Glukofazh for weight loss without diet and sufficient physical activity will not succeed. They start taking the drug with low doses (0.5 g per day), consistently selecting the effective one.

A common mistake many people make to lose weight as soon as possible is to start taking medications at high dosages, which leads to side effects, the most common of which are diarrhea and taste disturbances.

Glucophage Long or Siofor: which is better?

Glucophage Long is an extended form of metformin. If standard Glucophage or Siofor is prescribed 2-3 times a day, then Glucophage Long can be taken once a day.

In this case, fluctuations in its concentration in the blood plasma decrease, tolerance improves and the use becomes more convenient.

It costs about 2 times more expensive than other forms of drugs, but this pays off with a rare frequency of receptions.

Therefore, if there is a choice about which tablets are better to buy: Siofor, Glucophage or Glucophage Long, then the latter have the advantage.

A source: https://www.dosug5.info/chto-luchshe-siofor-ili-glyukofazh-pri-diabete-dlya-pohudeniya/

Siofor for weight loss, type 2 diabetes treatment and prevention

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Siofor is the world's most popular medicine for the prevention and treatment of type 2 diabetes. Siofor is the trade name of the drug, the active ingredient of which is metformin. This drug increases the sensitivity of cells to the action of insulin, i.e., it reduces insulin resistance.

  • Siofor for type 2 diabetes.
  • Diet pills are effective and safe.
  • Medication for the prevention of diabetes.
  • Reviews of patients with diabetes and losing weight.
  • What is the difference between Siofor and Glucophage.
  • How to take these pills.
  • Which dosage to choose - 500, 850 or 1000 mg.
  • What is the advantage of Glucophage Long.
  • Side effects and effects of alcohol.

Read the article!

Siofor for weight loss and type 2 diabetes

This medicine improves blood cholesterol and triglyceride levels, reduces the risk of cardiovascular disease, and, most importantly, helps to lose weight.

Millions of patients with type 2 diabetes around the world are taking Siofor. This helps them maintain good blood sugar, in addition to following their diet. If type 2 diabetes began to be treated on time, then Siofor (Glucophage) can help you do without insulin injections and other pills that lower blood sugar.

Siofor and Glucophage video

Instructions for the drug Siofor (metformin)

This article consists of a "mixture" of the official instructions for Siofor, information from medical journals and reviews of patients who take the drug. If you are looking for a manual for Siofor, then you will find all the necessary information with us. We hope that we were able to provide information about these well-deservedly popular tablets in the form most convenient for you.

Siofor, Glucophage and their analogues

Tradename

Siofor
Glucophage
Bagomet
Glyformin
Metfogamma
Metformin-Richter
Metospanin
NovoFormin
Formetin
Formin Pliva
Sofamet
Langerin
Metformin-Teva
Nova Met
Metformin Canon
Glucophage long
Metadien
Diaformin OD
Metformin MV-Teva

Glucophage is an original drug. It is produced by the company that invented metformin as a type 2 diabetes drug. Siofor is an analogue of the German company Menarini-Berlin Chemie. These are the most popular metformin tablets in Russian-speaking countries and in Europe. They are affordable and have good performance. Glucophage Long is a long-acting medicine. It causes digestive upset at half the rate of regular metformin. It is also believed that Glucophage Long is better at lowering sugar in diabetes. But this drug also costs much more. All other options for metformin tablets, which are listed above in the table, are rarely used. There is insufficient data on their effectiveness.

Indications for use

Diabetes mellitus type 2 (non-insulin dependent), for treatment and prevention. Especially in combination with obesity, if diet therapy and exercise without pills is not effective.

siofor instruction

For the treatment of diabetes, Siofor can be used as monotherapy (the only medicine), as well as in combination with other sugar-lowering tablets or insulin.

  • How to treat type 2 diabetes: a step by step method
  • Medication for type 2 diabetes: a detailed article
  • How to learn to enjoy exercise

Contraindications

Contraindications to the appointment of Siofor:

  • type 1 diabetes mellitus (*** except in cases of obesity. If you have type 1 diabetes plus obesity - taking Siofor may be beneficial, consult your doctor);
  • complete cessation of insulin secretion by the pancreas in type 2 diabetes mellitus;
  • diabetic ketoacidosis, diabetic coma;
  • renal failure with a blood creatinine level above 136 μmol / L in men and above 110 μmol / L in women, or a glomerular filtration rate (GFR) of less than 60 ml / min;
  • impaired liver function
  • cardiovascular failure, myocardial infarction;
  • respiratory failure;
  • anemia;
  • acute conditions that potentially contribute to renal dysfunction (dehydration, acute infections, shock, administration of iodine contrast agents);
  • X-ray studies with iodine-containing contrast - require temporary withdrawal of the syophore;
  • operations, injuries;
  • catabolic states (states with enhanced decay processes, for example, with tumor diseases);
  • chronic alcoholism;
  • lactic acidosis (including previously transferred);
  • pregnancy and lactation (breastfeeding) - do not take Siofor during pregnancy;
  • adherence to a diet with a significant restriction of calorie intake (less than 1000 kcal / day);
  • childhood;
  • hypersensitivity to drug components.

The instruction recommends that metformin tablets should be prescribed with caution to persons over 60 years of age if they are engaged in heavy physical work. Because this category of patients has an increased risk of developing lactic acidosis. In practice, the likelihood of this complication in people with healthy livers is close to zero.

Siofor for weight loss

On the Internet, you can find many positive reviews from people who take Siofor for weight loss. The official instructions for this drug do not mention that the drug can be used not only for the prevention or treatment of diabetes, but simply to get rid of excess weight.

However, these pills reduce appetite and improve metabolism so much that most people can "lose" a few pounds. The effect of Siofor for weight loss persists as long as a person takes it, but then the fat deposits quickly return.

It should be recognized that Siofor for weight loss is one of the safest options among all weight loss pills. Side effects (other than bloating, diarrhea, and flatulence) are extremely rare. In addition, it is also an affordable drug.

If you would like to use Siofor to lose weight, please read the section “Contraindications” first. It will also be correct to consult a doctor. If not with an endocrinologist, then with a gynecologist - they often prescribe this drug for polycystic ovary syndrome. Get blood and urine tests done to check your kidney function and how your liver is working.

When you take pills for weight loss, you need to stick to a diet at the same time. Officially, a “fast” low-calorie diet is recommended in such cases. But the site Diabet-Med.Com recommends using Siofor for weight loss plus a diet with limited carbohydrates in the diet for the best result. This could be the Ducan Diet, Atkins Diet, or Dr. Bernstein's Low Carb Diet for Diabetics. All of these diets are satisfying, healthy, and effective for weight loss.

Siofor for weight loss

Please do not exceed the recommended dose to avoid lactic acidosis. This is a rare complication, but deadly. If you exceed the recommended dosage, then you will not lose weight faster, and you will feel the side effects for the gastrointestinal tract in full. Remember that taking Siofor increases the chances of an unplanned pregnancy.

On the Russian-speaking Internet, you can find many reviews of women who take Siofor for weight loss. The assessments of this drug are very different - from enthusiastic to strongly negative.

siofor slimming tip

Each person has his own individual metabolism, not the same as everyone else. This means that the body's reaction to Siofor will also be individual. If you are not planning to take the pills at the same time as following a low-carb diet, then do not expect to lose as much excess weight as the author of the review above. Focus on minus 2-4 kg.

Siofor for lowering blood sugar and losing weight - review

Probably, Natalia followed a low-calorie diet, which does not help to lose weight, but, on the contrary, inhibits weight loss. If she had been on a low-carb diet, the result would have been very different. Siofor + protein diet is a quick and easy weight loss, with a good mood and without chronic hunger.

Siofor for diabetes and weight loss - review

Probably, the cause of Valentina's joint pain is a sedentary lifestyle, and taking pills for diabetes has nothing to do with it. Man is born to move. Physical activity is vital for us. If you lead a sedentary lifestyle, then after 40 years, degenerative diseases of the joints inevitably occur, including arthritis and osteochondrosis. The only way to slow them down is to learn how to exercise with pleasure and start doing it. Without movement, no pills will help, including glucosamine and chondroitin. And Siofor is nothing to scold. He conscientiously does his job, helping to lose weight and control diabetes.

Siofor helps to lose weight in diabetes - review

Another victim of the low-calorie, carbohydrate-laden diet that doctors prescribe for all diabetics. But Elena got off easy. She even manages to lose weight. But because of the wrong diet, there could be no sense at all from taking Siofor, neither for losing weight, nor for normalizing blood sugar.

Siofor - a review of losing weight

Natalia intelligently and slowly increased the dose and, thanks to this, was able to completely avoid side effects. Switch to a low-carbohydrate diet - and your weight will not creep, but fly down, collapse.

Siofor for the prevention of type 2 diabetes

The best way to prevent type 2 diabetes is by adopting a healthy lifestyle. In particular, increasing physical activity and changing eating habits. Unfortunately, the vast majority of patients in their daily life do not follow the recommendations for changing their lifestyle.

Therefore, the question of developing a strategy for the prevention of type 2 diabetes with the use of a drug has become so acute. Since 2007, there have been official recommendations from the American Diabetes Association experts on the use of Siofor for diabetes prevention.

Siofor for the prevention of type 2 diabetes

The study, which lasted 3 years, showed that the use of Siofor or Glucophage reduces the risk of diabetes by 31%. For comparison: if you switch to a healthy lifestyle, then this risk will decrease by 58%.

The use of metformin tablets for prophylaxis is recommended only in patients with a very high risk of diabetes. This group includes obese people under the age of 60 who additionally have one or more of the following risk factors:

  • the level of glycated hemoglobin is above 6%:
  • arterial hypertension;
  • decreased level of "good" cholesterol (high density) in the blood;
  • increased levels of triglycerides in the blood;
  • had type 2 diabetes in close relatives.
  • body mass index greater than or equal to 35.

In such patients, the appointment of Siofor for the prevention of diabetes at a dosage of 250-850 mg 2 times a day can be discussed. Today, Siofor or its variety Glucophage is the only drug that is considered as a means of preventing diabetes.

special instructions

It is necessary to monitor the functions of the liver and kidneys before prescribing metformin tablets and then every 6 months. You should also check your blood lactate levels twice a year or more.

When treating diabetes with a combination of Siofor with sulfonylurea derivatives, there is a high risk of hypoglycemia. Therefore, careful monitoring of blood glucose levels is required, several times a day.

Due to the risk of hypoglycemia, patients who take Siofor or Glucophage are not recommended to engage in activities that require concentration and rapid psychomotor reactions.

one.
  • You can eat anything you want and lose weight at the same time. That's what pills are for
  • Limit calorie intake and dietary fats
  • Go on a low-carbohydrate diet (Atkins, Ducan, Kremlin, etc.)
  • 2.
    • Start taking at the lowest dose, gradually increasing it
    • Take pills with food
    • You can switch from regular Siofor to Glucophage Long
    • All of the above actions are correct.
  • 3.
    • Pregnancy
    • Renal failure - glomerular filtration rate 60 ml / min and below
    • Heart failure, recent heart attack
    • Type 2 diabetes in a patient turned into severe type 1 diabetes
    • Liver disease
    • All listed
  • four.
    • Switch to a low-carb diet first
    • Add more tablets - sulfonylurea derivatives that stimulate the pancreas
    • Exercise, preferably by jogging slowly
    • If diet, pills and physical education do not help, then start injecting insulin, do not waste time
    • All of the above actions are correct, except for taking medications - sulfonylurea derivatives. These are bad pills!
  • five.
    • Glucophage is the original drug, and Siofor is an inexpensive generic
    • Glucophage Long causes indigestion 3-4 less often
    • If you take Glucophage Long at night, it improves sugar in the morning on an empty stomach. Siofor is not suitable here, because his action is not enough for the whole night
    • All answers are correct
  • 6.
    • Siofor works stronger than other diet pills
    • Because it gives you safe weight loss without serious side effects
    • Siofor causes weight loss, because it temporarily disrupts digestion, but this is not harmful
    • Taking Siofor, you can eat “forbidden” foods
  • 7.
    • Yes, if the patient is obese and requires significant doses of insulin
    • No, no pills work for type 1 diabetes.
  • 8.
  • Side effects

    In 10-25% of patients taking Siofor, there are complaints of side effects from the digestive system, especially at the beginning of therapy. This "metallic" taste in the mouth, decreased appetite, diarrhea, bloating and gas, abdominal pain, nausea and even vomiting.

    To reduce the frequency and intensity of the listed side effects, you need to take Siofor during or after meals, and gradually increase the dose of the drug. Side effects from the gastrointestinal tract are not a reason to cancel Siofor therapy. Because after a while, they usually go away, even with the same dosage.

    Metabolic disorders: extremely rarely (with an overdose of the drug, in the presence of concomitant diseases in which the use of Siofor is contraindicated, with alcoholism), lactic acidosis may develop. This requires immediate discontinuation of the medication.

    Siofor and alcohol

    From the hematopoietic system: in some cases - megaloblastic anemia. With prolonged treatment with Siofor, hypovitaminosis B12 may develop (impaired absorption). Allergic reactions are very rare - skin rashes.

    From the endocrine system: hypoglycemia (in case of drug overdose).

    Pharmacokinetics

    After oral administration, the maximum concentration of metformin (this is the active substance of syophor) in the blood plasma is reached after about 2.5 hours. If the tablets are taken with meals, the absorption is slightly slowed down and reduced. The maximum concentration of metformin in plasma, even at the maximum dosage, does not exceed 4 μg / ml.

    The instructions say that its absolute bioavailability in healthy patients is approximately 50-60%. The drug practically does not bind to plasma proteins. The active substance is excreted in the urine completely (100%) unchanged. That is why the drug is not prescribed to patients whose renal glomerular filtration rate is less than 60 ml / min.

    The renal clearance of metformin is more than 400 ml / min. It exceeds the glomerular filtration rate. This means that Siofor is excreted from the body not only by glomerular filtration, but also through active secretion in the proximal renal tubules.

    After oral administration, the elimination half-life is about 6.5 hours. In renal failure, the rate of elimination of syophor decreases in proportion to the decrease in creatinine clearance. Thus, the half-life is lengthened and the concentration of metformin in the blood plasma is increased.

    Does Siofor remove calcium and magnesium from the body?

    Does taking Siofor worsen the deficiency of magnesium, calcium, zinc and copper in the body? Romanian experts decided to find out. Their study involved 30 people between the ages of 30 and 60 who had just been diagnosed with type 2 diabetes and had no previous treatment for it. All of them were prescribed Siofor 500 mg 2 times a day. From the pills, only Siofor was prescribed to track its effect. Doctors made sure that the foods each participant ate contained 320 mg of magnesium per day. Magnesium-B6 tablets were not prescribed to anyone.

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    A control group of healthy people without diabetes was also formed. They did the same tests to compare their results with those of diabetics. Type 2 diabetes who had kidney failure, cirrhosis, psychosis, pregnancy, chronic diarrhea, or who were taking diuretics were not allowed to participate in the study.

    The level of magnesium in the blood of patients with type 2 diabetes is lower than in healthy people. Deficiency of magnesium in the body is one of the reasons for the development of diabetes. When diabetes has already developed, the kidneys excrete excess sugar in the urine, and because of this, the loss of magnesium is further increased. Patients with diabetes who develop complications are more severely deficient in magnesium than those with diabetes without complications. Magnesium is part of over 300 enzymes that regulate the metabolism of proteins, fats and carbohydrates. It has been proven that magnesium deficiency enhances insulin resistance in patients with metabolic syndrome or diabetes. And taking magnesium supplements, albeit slightly, still increases the sensitivity of cells to insulin. Although the most important treatment for insulin resistance is a low-carbohydrate diet, everyone else lags behind by a wide margin.

    Zinc is one of the most important trace elements in the human body. It is required for more than 300 different processes in cells - enzyme activity, protein synthesis, signal transmission. Zinc is essential for the functioning of the immune system, maintaining biological balance, neutralizing free radicals, slowing down aging and preventing cancer.

    Taking Siofor 1000 mg per day does not reduce zinc reserves in the body

    Copper is also a vital trace element, it is part of many enzymes. However, copper ions are involved in the production of dangerous reactive oxygen species (free radicals), therefore they are oxidants. Both deficiency and excess of copper in the body cause various diseases. At the same time, excess is more common. Type 2 diabetes is a chronic metabolic disorder in which too many free radicals are produced, causing oxidative stress to damage cells and blood vessels. Tests show that diabetics are often overloaded with copper.

    There are many different pills that are prescribed for type 2 diabetes. The most popular drug is metformin, which is sold under the names Siofor and Glucophage. It has been proven that it does not lead to weight gain, but rather helps to lose weight, improves blood cholesterol levels, and all this without harmful side effects. Siofor or prolonged Glucophage is recommended to be prescribed immediately, as soon as the patient is diagnosed with type 2 diabetes or metabolic syndrome.

    Romanian doctors decided to answer the following questions:

    • What is the typical level of minerals and trace elements in the body of patients who have just been diagnosed with type 2 diabetes? Elevated, Decreased, or Normal?
    • How does taking metformin affect magnesium, calcium, zinc and copper in the body?

    To do this, they measured in their diabetic patients:

    • plasma concentration of magnesium, calcium, zinc and copper;
    • the content of magnesium, calcium, zinc and copper in a 24-hour portion of urine;
    • the level of magnesium in erythrocytes (!);
    • and also - "good" and "bad" cholesterol, triglycerides, fasting blood sugar, glycated hemoglobin HbA1C.

    Patients with type 2 diabetes underwent blood and urine tests:

    • at the beginning of the study;
    • then again - after 3 months of taking metformin.

    The content of trace elements in the body of patients with type 2 diabetes and healthy people

    At the start of the study

    At the start of the study

    We can see that diabetic patients have reduced levels of magnesium and zinc in the blood, compared with healthy people. There are dozens of articles in English-language medical journals that show that magnesium and zinc deficiencies are one of the causes of type 2 diabetes. Excess copper is the same. For your information, if you take zinc tablets or capsules, it saturates the body with zinc and at the same time displaces excess copper from it. Few people know that zinc supplements have this dual effect. But you don't need to get too carried away with them, so as not to form a copper deficit. Take zinc in courses 2-4 times a year.

    The test results showed that taking metformin does not increase the deficiency of trace elements and minerals in the body. Because the excretion of magnesium, zinc, copper and calcium in the urine in type 2 diabetics did not increase after 3 months. Against the background of treatment with Siofor tablets, the magnesium content in the body increased in diabetics. The study authors attribute this to Siofor's action. I am convinced that diabetes pills have nothing to do with it, but simply that the study participants ate healthier foods while the doctors watched them.

    Against the background of treatment with Siofor tablets, the magnesium content in the body increased in diabetic patients

    There was more copper in the blood of diabetics than in healthy people, but the difference with the control group was not statistically significant. However, Romanian doctors have noticed that the more copper there is in the blood plasma, the more severe diabetes is. Recall that the study involved 30 patients with type 2 diabetes. After 3 months of therapy, it was decided to leave 22 of them on Siofor, and 8 more tablets were added - sulfonylurea derivatives. Because Siofor did not lower their sugar enough. Those who continued to be treated with Siofor had 103.85 ± 12.43 mg / dl of copper in the blood plasma, and those who had to prescribe sulfonylurea derivatives - 127.22 ± 22.64 mg / dl.

    The authors of the study established and statistically proved the following relationships:

    • Taking Siofor 1000 mg per day does not increase the excretion of calcium, magnesium, zinc and copper from the body.
    • The more magnesium in the blood, the better the glucose readings.
    • The more magnesium in the erythrocytes, the better the sugar and glycated hemoglobin values.
    • The more copper, the worse the indicators for sugar, glycated hemoglobin, cholesterol and triglycerides.
    • The higher the level of glycated hemoglobin, the more zinc is excreted in the urine.
    • Blood calcium levels are not different between type 2 diabetics and healthy people.

    I draw your attention to the fact that a blood test for magnesium in plasma is not reliable, it does not show a deficiency of this mineral. It is imperative to do an analysis for the magnesium content in erythrocytes. If this is not possible, and you feel the symptoms of magnesium deficiency in the body, then just take magnesium tablets with vitamin B6. This is safe, unless you have severe kidney disease. At the same time, calcium has little or no effect on diabetes. Taking magnesium tablets with vitamin B6 and zinc capsules is many times more important than calcium.

    pharmachologic effect

    Siofor - pills for lowering blood sugar from the biguanide group. The drug reduces the concentration of glucose in the blood both on an empty stomach and after meals. Does not cause hypoglycemia because it does not stimulate insulin secretion. Metformin's action is likely based on the following mechanisms:

    • suppression of excess production of glucose in the liver by inhibiting gluconeogenesis and glycogenolysis, ie, Siofor suppresses the synthesis of glucose from amino acids and other "raw materials", and also prevents its extraction from glycogen stores;
    • improving the supply of glucose to peripheral tissues and its utilization there, by reducing the insulin resistance of cells, that is, the tissues of the body become more sensitive to the action of insulin, and therefore the cells better "admit" glucose into themselves;
    • slowing down the absorption of glucose in the intestine.

    Regardless of the effect on blood glucose concentration, Siofor and its active ingredient metformin improves lipid metabolism, lowers blood triglycerides, increases "good" cholesterol (high density) and lowers blood levels of "bad" low density cholesterol.

    Siofor and blood cholesterol

    The metformin molecule is easily incorporated into the lipid bilayer of cell membranes. Siofor has an effect on cell membranes, including:

    • suppression of the mitochondrial respiratory chain;
    • an increase in the activity of the tyrosine kinase of the insulin receptor;
    • stimulation of translocation of the glucose transporter GLUT-4 to the plasma membrane;
    • activation of AMP-activated protein kinase.

    The physiological function of the cell membrane depends on the ability of protein components to move freely in the lipid bilayer. An increase in membrane stiffness is a common feature of diabetes mellitus, which can provoke complications of the disease.

    Studies have shown that metformin increases the fluidity of plasma membranes of human cells. The effect of the drug on the mitochondrial membranes is especially important.

    Siofor and Glucophage increase insulin sensitivity predominantly of skeletal muscle cells and, to a lesser extent, adipose tissue. The official instruction states that the drug reduces the absorption of glucose in the intestine by 12%. Millions of patients have found that this drug reduces appetite. Against the background of taking the pills, the blood becomes less thick, the likelihood of the formation of dangerous blood clots decreases.

    Glucophage or Siofor: what to choose?

    Glucophage Long is a new dosage form of metformin. It differs from Siophor in that it has a prolonged action. The medicine from the pill is not absorbed immediately, but gradually. In a conventional siophor, 90% of metformin from a tablet is released within 30 minutes, and in glucophage long - gradually, over 10 hours.

    If the patient does not take Siofor, but Glucophage Long, then the peak concentration of metformin in the blood plasma is reached much more slowly.

    Advantages of Glucophage Long over the "regular" Siofor:

    • it is enough to take it once a day;
    • side effects from the gastrointestinal tract with the same dosage of metformin develop 2 times less often;
    • better control blood sugar during the night and in the morning on an empty stomach;
    • the effect of lowering the level of glucose in the blood is not worse than that of the “ordinary” syophor.

    What to choose - Siofor or Glucophage Long? Answer: If you do not tolerate Siofor well due to bloating, flatulence or diarrhea, try glucophage. If everything is fine with Siofor, continue taking it, because glucophage long tablets are more expensive. Diabetes treatment guru Dr. Bernstein believes that glucophage works more effectively than the "fast" metformin pills. But hundreds of thousands of patients were convinced that the usual siofor is powerful. Therefore, it makes sense to overpay for glucophage only to reduce digestive upset.

    Dosage of Siofor tablets

    The dose of the drug is set individually each time, depending on the level of glucose in the blood and how the patient tolerates the treatment. Many patients stop Siofor therapy due to flatulence, diarrhea, and abdominal pain. Often these side effects are caused only by inappropriate dosage selection.

    Dosage of Siofor tablets

    The best way to take Siofor is with a gradual increase in dose. You need to start with a low dose - no more than 0.5-1 g per day. These are 1-2 tablets of the drug of 500 mg each or one tablet of Siofor 850. If there are no side effects from the gastrointestinal tract, then after 4-7 days you can increase the dose from 500 to 1000 mg or from 850 mg to 1700 mg per day, i.e. from one tablet a day to two.

    If at this stage there are side effects from the gastrointestinal tract, then you should “roll back” the dose to the previous one, and later try to increase it again. From the instructions for Siofor, you can find out that its effective dose is 2 times a day, 1000 mg. But often it is enough to take 850 mg 2 times a day. For patients with a large physique, a dose of 2500 mg / day may be optimal.

    The maximum daily dose of Siofor 500 is 3 g (6 tablets), Siofor 850 is 2.55 g (3 tablets). The average daily dose of Siofor® 1000 is 2 g (2 tablets). Its maximum daily dose is 3 g (3 tablets).

    Metformin tablets in any dosage should be taken with food, without chewing, with a sufficient amount of liquid. If the prescribed daily dose is more than 1 tablet, divide it into 2-3 doses. If you miss a pill, you should not make up for it by taking more pills once the next time.

    How long to take Siofor is determined by the doctor.

    Overdose

    In case of an overdose of Siofor, lactic acidosis may develop. Its symptoms: severe weakness, breathing disorders, drowsiness, nausea, vomiting, diarrhea, abdominal pain, cold extremities, decreased blood pressure, reflex bradyarrhythmia.

    The patient may complain of muscle pain, confusion and loss of consciousness, rapid breathing. Lactic acidosis therapy is symptomatic. This is a dangerous complication that can lead to death. But if you do not exceed the dose and everything is fine with your kidneys, then the probability of it is almost zero.

    Drug interactions

    This drug has a unique property. This is the ability to combine it with any other means to lower the concentration of glucose in the blood. Siofor can be administered in conjunction with any other type 2 diabetes pill or insulin.

    Siofor can be used in combination with the following medicines:

    • secretatogi (sulfonylurea derivatives, meglitinides);
    • thiazolinediones (glitazones);
    • incretin drugs (GLP-1 analogs / agonists, DPP-4 inhibitors);
    • drugs that reduce the absorption of carbohydrates (acarbose);
    • insulin and its analogues.

    There are groups of drugs that can enhance the blood sugar-lowering effect of metformin when used concurrently. These are sulfonylurea derivatives, acarbose, insulin, NSAIDs, MAO inhibitors, oxytetracycline, ACE inhibitors, clofibrate derivatives, cyclophosphamide, beta-blockers.

    The instructions for Siofor say that some other groups of drugs can weaken its effect on lowering blood sugar if the drugs are used simultaneously. These are GCS, oral contraceptives, epinephrine, sympathomimetics, glucagon, thyroid hormones, phenothiazine derivatives, nicotinic acid derivatives.

    Siofor can weaken the effect of indirect anticoagulants. Cimetidine slows down the excretion of metformin, which increases the risk of lactic acidosis.

    Do not drink alcoholic beverages while taking Siofor! With simultaneous use with ethanol (alcohol), the risk of developing a dangerous complication - lactic acidosis increases.

    Furosemide increases the maximum concentration of metformin in blood plasma. At the same time, metformin reduces the maximum concentration of furosemide in the blood plasma and its half-life.

    Nifedipine increases the absorption and maximum concentration of metformin in the blood plasma, delays its excretion.

    Cationic drugs (amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, vancomycin), which are secreted in the tubules, compete for tubular transport systems. Therefore, with prolonged therapy, they can increase the concentration of metformin in the blood plasma.

    In this article, we discussed the following topics in detail:

    • Siofor for weight loss;
    • Metformin tablets for the prevention and treatment of type 2 diabetes;
    • When is it advisable to take this medication for type 1 diabetes;
    • How to choose a dosage so that there is no digestive upset.

    For type 2 diabetes, don't limit yourself to taking Siofor and other pills, but follow our type 2 diabetes treatment program. To die quickly from a heart attack or stroke is half the trouble. And turning into a bedridden invalid due to complications of diabetes is truly scary. Learn from us how to control diabetes without "hungry" diets, exhausting exercise and 90-95% of cases without insulin injections.

    If you have questions about the medicine Siofor (Glucophage), then you can ask them in the comments, the site administration quickly answers.

    Siofor 1000: instructions for the use of tablets for diabetes

    Siofor 1000 is a drug that belongs to the group of drugs for getting rid of type 2 diabetes mellitus (non-insulin dependent).

    The drug lowers blood sugar in adults, as well as in pediatric patients from the age of 10 (who have type 2 diabetes).

    Glucophage or Siofor - which is betterIt can be used to treat patients with large body weight, provided that dietary nutrition and physical activity are insufficiently effective. The instructions for use of the drug say that it helps reduce the likelihood of diabetic organ damage in the adult category of overweight patients.

    The drug can be used as monotherapy for children from 10 years of age, as well as for adults. In addition, Siofor 1000 can also be used in combination with other agents that lower blood glucose. These are oral medications as well as insulin.

    The main contraindications

    The drug is not recommended for use in such cases:

    1. there is excessive sensitivity to the main active ingredient (metformin hydrochloride) or other components of the drug;
    2. subject to the manifestation of symptoms of complications against the background of the course of diabetes mellitus. This can be a strong increase in the concentration of glucose in the blood or a significant oxidation of the blood due to the accumulation of ketone bodies. A sign of such a condition will be severe pain in the abdominal cavity, too shortness of breath, drowsiness, as well as an unusual, unnatural fruit smell from the mouth;
    3. liver and kidney diseases;

    Extremely acute conditions that can cause kidney disease, such as:

    • infectious diseases;
    • great loss of fluid as a result of vomiting or diarrhea;
    • insufficient blood circulation;
    • when it becomes necessary to administer a contrast agent containing iodine. This may be required for various medical examinations, such as x-rays;

    For those diseases that can cause oxygen starvation, for example:

    1. cardiac insufficiency;
    2. impaired kidney function;
    3. insufficient blood circulation;
    4. recent heart attack;
    5. during the period of acute alcohol intoxication, as well as with alcoholism.

    In case of pregnancy and lactation, the use of Siofor 1000 is also prohibited. In such situations, the attending physician should replace the agent with insulin preparations.

    If at least one of these conditions occurs, you must inform your doctor about it.

    Application and dosage

    The drug Siofor 1000 must be taken as closely as possible according to the doctor's prescription. For any manifestations of adverse reactions, you should consult a doctor.

    Siofor 1000 mg, 30 tabletsDoses of funds should be determined in each case individually. The prescription will be based on what your blood glucose level is. This is extremely important for the treatment of all categories of patients.

    Siofor 1000 is produced in tablet format. Each tablet is film-coated and contains 1000 mg of metformin. In addition, there is a form of release of this drug in the form of tablets of 500 mg and 850 mg of the substance in each.

    The following treatment regimen will be fair provided:

    • use of Siofor 1000 as an independent drug;
    • combination therapy along with other oral medications that can lower blood sugar (in adult patients);
    • joint use with insulin.

    Adult patients

    The usual initial dose will be the Ug of a film-coated tablet (this will correspond to 500 mg of metformin hydrochloride) 2-3 times a day or 850 mg of the substance 2-3 times a day (such a dose of Siofor 1000 is not possible), instructions for use it clearly denotes.

    After 10-15 days, the attending physician will adjust the required dosage depending on the concentration of glucose in the blood. The volume of the drug will gradually increase, which becomes the key to better tolerance of the drug by the digestive system.

    After making adjustments, the dose will be as follows: 1 tablet Siofor 1000, coated, twice a day. The indicated volume will correspond to 2000 mg of metformin hydrochloride in 24 hours.

    Maximum daily dose: 1 tablet Siofor 1000, coated, three times a day. The volume will correspond to 3000 mg of metformin hydrochloride per day.

    Children from 10 years of age

    SioforThe usual dose of the drug is 0.5 g of a film-coated tablet (this will correspond to 500 mg of metformin hydrochloride) 2-3 times a day, or 850 mg of the substance once a day (such a dose is not possible).

    After 2 weeks, the doctor will adjust the required dose based on the blood glucose concentration. Gradually, the volume of Siofor 1000 will increase, which becomes the key to better tolerance of the drug from the gastrointestinal tract.

    After making adjustments, the dose will be as follows: 1 coated tablet twice a day. This amount will correspond to 1000 mg of metformin hydrochloride per day.

    The maximum amount of active ingredient will be 2000 mg, which corresponds to 1 film-coated tablet of Siofor 1000.

    Adverse reactions and overdose

    Like all medicines, Siofor 1000 can cause some side reactions, but not all patients taking the medicine may develop them.

    If there is an overdose of the drug, then in such a situation, you should immediately seek medical help.

    Drinking too much volume does not cause an excessive decrease in blood glucose concentration (hypoglycemia), however, there is a high likelihood of rapid oxidation of the patient's blood with lactic acid (lactic acidosis).

    In any case, urgent medical attention and treatment are needed in a hospital setting.

    Interaction with some medicinal products

    If the use of the drug is envisaged, then in this case it is extremely important to inform the attending physician about all those drugs that were used by patients with diabetes mellitus until recently. Even over-the-counter products should be mentioned.

    With Sifor 1000 therapy, there is a possibility of unexpected drops in blood sugar at the very beginning of treatment, as well as after the end of taking other medicines. During this period of time, you need to carefully monitor the concentration of glucose.

    If at least one of the following drugs is used, then this should not be ignored by the doctor:

    • corticosteroids (cortisone);
    • some types of drugs that can be used with high blood pressure or insufficient work of the heart muscle;
    • diuretics used to lower blood pressure (diuretics);
    • preparations for getting rid of bronchial asthma (beta-sympathomimetics);
    • contrast agents containing iodine;
    • alcohol-containing medicines;

    It is important to warn the doctor about the use of such drugs that can negatively affect the functioning of the kidneys:

    • medicines to lower blood pressure levels;
    • drugs that reduce the symptoms of ARVI or rheumatism (pain, fever).

    Features of the use of the drug Siofor 1000

    Rarely enough, when using Sifor 1000, the risk of extremely rapid blood oxidation by lactic acid may develop. This process will be called lactic acidosis.

    диабетическая комаThis happens when there are significant problems in the functioning of the kidneys. The main reason for this may be an unwanted accumulation of metformin hydrochloride in the body of a diabetic, the instructions for use precisely indicate this moment.

    If you do not take appropriate measures, then there is a high probability of a coma, a diabetic coma develops.

    To reduce the risk of coma, it is necessary to take into account absolutely all contraindications to the use of Siofor 1000, and also do not forget to adhere to the dose recommended by the doctor.

    The manifestations of lactic acidosis may be similar to the side effects of metformin hydrochloride on the part of the digestive system:

    • diarrhea;
    • sharp pains in the abdominal cavity;
    • repeated vomiting;
    • nausea.

    In addition, for several weeks, the likelihood of pain in the muscles or rapid breathing is possible. Clouding of consciousness, as well as coma, may also appear.

    If these symptoms occur, then the drug should be discontinued and immediate medical attention should be sought. There are cases when treatment is required in a hospital setting.

    The main active ingredient of the drug Siofor 1000 is excreted by the kidneys. In view of this, before starting therapy, the state of the organ should be examined. Diagnostics must be carried out at least once a year, and more often if necessary.

    It is necessary to monitor the work of the kidneys extremely carefully in such situations:

    • the patient is over 65 years old;
    • at the same time, medications were used that cause a detrimental effect on the functioning of the kidneys.

    Therefore, it is always necessary to tell the doctor about all the medicines taken, and carefully read the instructions for use.

    Subject to the introduction of a contrast agent containing iodine, there is a possibility of impaired renal function. This leads to a violation of the excretion of the active substance of the drug Siofor 1000.

    Doctors recommend stopping the use of Siofor 1000 two days before the expected X-ray or other studies. The resumption of the use of the drug begins 48 hours after it has been carried out.

    If a planned surgical intervention was prescribed with the use of general anesthesia or spinal anesthesia, then in this case, the use of the drug Siofor 1000 is also stopped. As in previous cases, the drug is canceled 2 days before the manipulation.

    You can continue taking it only after the resumption of nutrition or no sooner than 48 hours after the operation. However, the doctor must first check the functioning of the kidneys. In addition, it is important to monitor the functioning of the liver.

    Subject to the consumption of alcoholic beverages, the risk of a sharp drop in glucose levels and the development of lactic acidosis increases several times. In view of this, the drug and alcohol are absolutely incompatible.

    Precautions

    During therapy with the Siofor 1000 preparation, it is necessary to adhere to a certain diet with high quality and pay close attention to the consumption of carbohydrate foods. It is important to consume foods high in starch as evenly as possible:

    • potatoes;
    • pasta;
    • fruit;
    • fig.

    If the patient has a history of overweight, then a special low-calorie diet should be followed. This should take place under the close supervision of the attending physician.

    To control the course of diabetes mellitus, it is necessary to regularly take a blood sugar test.

    Siofor 1000 cannot cause hypoglycemia. If used simultaneously with other drugs for diabetes mellitus, the likelihood of a sharp drop in blood glucose levels may increase. We are talking about preparations of insulin and sulfonylureas.

    Children from 10 years old and adolescents

    дети с диабетомBefore prescribing the use of Siofor 1000 to this age group, the endocrinologist must confirm the presence of type 2 diabetes mellitus in the patient.

    Therapy with the help of the tool is carried out with an adjustment in the diet, as well as with the connection of regular moderate physical exertion.

    As a result of one-year controlled medical studies, the effect of the main active ingredient of Siofor 1000 (metformin hydrochloride) on the growth, development and puberty of children has not been established.

    No longer studies have been conducted to date.

    The experiment involved children from 10 to 12 years old.

    Elderly people

    Due to the fact that in elderly patients renal function is often impaired, the dosage of Siofor 1000 should be adjusted. To do this, in a hospital, regular kidney tests are performed.

    special instructions

    Siofor 1000 is not able to influence the ability to adequately drive vehicles and does not affect the quality of maintenance of mechanisms.

    If used simultaneously with other drugs for the treatment of diabetes mellitus (insulin, repaglinide or sulfonylurea), there may be an impairment in the ability to drive vehicles due to a decrease in the patient's blood glucose concentration.

    Siofor 1000 release form and basic storage conditions

    Siofor 1000 is produced in packs of 10, 30, 60, 90 or 120 coated tablets. Not all package sizes of this type 2 diabetes mellitus may be available in the pharmacy chain.

    It is necessary to store the drug in places where there is no access to children. The use of the drug Siofor for 1000 children should take place under the strict supervision of adults.

    The medicine cannot be used for treatment after the expiration date, which is indicated on each blister or pack.

    The term of possible use ends with the last day of the month that is written on the package.

    There are no special conditions for storing Siofor 1000.

    Glucophage for diabetes

    Metabolic syndrome, the main features of which are considered obesity, type 2 diabetes mellitus and hypertension, is a problem in today's civilized society. An increasing number of the population of favorable states are suffering from this syndrome.

    • Glucophage for type 2 diabetes
    • Composition and release forms of the drug
    • Glucophage Long for diabetes mellitus
    • Mechanism of action
    • Who should not take this drug?
    • Glucophage and children
    • Side effects of Glucophage
    • What other drugs affect Glucophage?
    • Frequently asked Questions
    • Siofor or Glucophage: which is better for diabetes?
    • Glucophage for diabetes: reviews

    глюкофаж как принимать

    How can you help yourself to restore the state of the body with the least energy expenditure? In fact, the bulk of obese people are unwilling or unable to play sports, and diabetes mellitus is, in fact, an insurmountable disease. The pharmaceutical industry comes to the rescue.

    Glucophage for type 2 diabetes

    One of the drugs that lower blood glucose levels and help you lose weight is glucophage. In accordance with the provided research data, taking this drug reduces the death rate from diabetes by 53%, by 35% from myocardial infarction and by 39% from stroke.

    Composition and release forms of the drug

    Metformin hydrochloride is considered the primary functional element of the drug. The additional components are:

    • magnesium stearate;
    • povidone;
    • microcrystalline fiber;
    • hypromellose (2820 and 2356).

    The medicinal product is available in the form of pills, tablets with a dosage of the main constituent substance in the amount of 500, 850 and 1000 mg. Biconvex tablets for diabetes Glucophage have the shape of an ellipse.

    They are covered with a protective layer of white shell. There are special risks on both sides of the tablet, one of which shows the dosage.

    Glucophage Long for diabetes mellitus

    Glucophage Long is a particularly effective metformin due to its own long-term therapeutic results.

    The special therapeutic form of this substance makes it possible to achieve the same effects as when using ordinary metformin, however, the effect persists for a long time, therefore, using Glucophage Long in most cases will be enough once a day.

    This significantly improves the tolerability of the drug and the quality of life of patients.

    глюкофаж лонг

    A special development used in the manufacture of tablets allows the functioning substance to emancipate into the lumen of the intestinal tract evenly and uniformly, as a result of which the optimal glucose level is maintained around the clock, without any jumps or drops.

    Externally, the tablet is covered with a gradually dissolving film, inside there is a base with metformin elements. As the shell slowly dissolves, the influencing substance itself is evenly released. At the same time, contraction of the intestinal tract and acidity do not have a large effect on the course of metformin release, therefore, a good result takes place in different patients.

    One-time use of Glucophage Long replaces the constant multiple daily intake of ordinary metformin. This makes it possible to exclude undesirable reactions from the gastrointestinal tract, which occur when taking conventional metformin, due to an acute increase in its concentration in the blood.

    Mechanism of action

    The drug belongs to the biguanide group and is produced to lower blood glucose levels. The principle of glucophage is that by lowering the level of glucose, it does not in any way lead to a hypoglycemic crisis.

    In addition, it does not increase insulin production and does not affect glucose levels in healthy people. The peculiarity of the mechanism of influence of glucophage is based on the fact that it enhances the sensitivity of receptors to insulin and activates the processing of sugars by muscle cells.

    похудение глюкофаж

    Reduces the accumulation of glucose in the liver, as well as the absorption of carbohydrates by the digestive organs. It has an excellent effect on fat metabolism: it reduces the amount of cholesterol, triglycerides and low density lipoproteins.

    The bioavailability of the product is at least 60%. It is quickly absorbed through the walls of the gastrointestinal tract and the largest amount of substance in the blood enters 2 and a half hours after oral administration.

    The functional substance does not affect the blood proteins and is quickly carried through the cells of the body. It is absolutely not processed by the liver and is excreted in the urine. There is a risk of inhibition of the drug in tissues in people with reduced kidney function.

    Who should not take this drug?

    Some patients taking Glucophage suffer from a dangerous condition - lactic acidosis. It is caused by a buildup of lactic acid in the blood and occurs most often in people who have kidney problems.

    For most people with this kind of disease, doctors do not prescribe this drug. Plus, there are other conditions that can increase your chances of getting lactic acidosis.

    These apply to patients who:

    • liver problems;
    • heart failure;
    • there is a reception of incompatible drugs;
    • the period of pregnancy or lactation;
    • surgical intervention is planned in the near future.

    Glucophage and children

    The side effects of taking the drug in children under 10 years of age have not been studied; the drug successfully helps children aged 10 to 16 with type 2 diabetes.

    Side effects of Glucophage

    In rare cases, Glucophage can lead to a serious side effect - lactic acidosis. This usually happens in people who have kidney problems.

    According to statistics, approximately one in 33,000 patients who have taken Glucophage for one year suffers from this side effect. This condition is rare, but can be fatal in 50% of people who have it.

    If you see any signs of lactic acidosis, you should immediately stop taking the drug and consult your doctor.

    Signs of lactic acidosis are:

    • weakness;
    • muscle pain;
    • breathing problems;
    • feeling cold;
    • dizziness;
    • a sudden change in the rhythm of the heartbeat - tachycardia;
    • discomfort in the stomach.

    Common side effects from taking Glucophage:

    • diarrhea;
    • nausea;
    • stomach upset.

    These side effects tend to disappear with prolonged use. About 3% of people who take this drug experience a metallic taste when taking the medication.

    What other drugs affect Glucophage?

    Talk to your doctor about taking medications at the same time as Glucophage.

    It is not recommended to combine this drug with:

    Concomitant use of the following medicines with Glucophage can cause hyperglycemia (high blood sugar), namely with:

    • phenytoin;
    • birth control pills or hormone replacement therapy;
    • diet pills or medicines for asthma, colds, or allergies;
    • diuretic tablets;
    • heart or hypertensive medications;
    • niacin (Advicor, Niaspan, Niacor, Simcor, Srb-niacin, etc.);
    • phenothiazines (Kompazin and others);
    • steroid therapy (prednisone, dexamethasone and others);
    • hormonal preparations for the thyroid gland (Synthroid, etc.).

    This list is not complete. Other drugs can increase or decrease the effect of Glucophage on lowering blood sugar levels.

    Frequently asked Questions

    1. What happens if I miss a dose?

    Take the missed dose as soon as you remember (be sure to take it with food). Skip the missed dose if there is little time before your next scheduled dose. It is not recommended to take additional medications to make up for a missed dose.

    1. What happens in case of an overdose?

    An overdose of metformin can cause lactic acidosis, which can be fatal.

    1. What should I avoid while taking Glucophage?

    Avoid drinking alcohol. It lowers blood sugar and may increase your risk of lactic acidosis while taking Glucophage.

    Siofor or Glucophage: which is better for diabetes?

    The active substance of Glucophage is metformin. Metformin is not a trade name, but an international non-proprietary name. Siofor is the trade name for metformin from Berlin Chemie. Therefore, Siofor and Glucophage have the same active ingredient.

    Glucophage for diabetes: reviews

    To compile a general picture of the course of diabetes mellitus under the influence of Glucophage, a survey was conducted among patients. To simplify the results, the reviews were divided into three groups and the most objective ones were selected:

    1. Efficiency: high

    I went to the doctor with the problem of rapid weight loss despite lack of diet and physical activity, and after a medical examination I was diagnosed with severe insulin resistance and hypothyroidism, which contributed to the weight problem. My doctor told me to take metformin at the maximum dose, 850 mg, 3 times a day and start thyroid medication. Within 3 months, the weight stabilized, and the production of insulin was restored. I was scheduled to take Glucophage for the rest of my life.

    Conclusion: regular use of Glucophage gives positive results at high dosage.

    1. Efficiency: Medium

    We took Glucophage 2 times a day with my wife. I missed the appointment a couple of times. Lowered my blood sugar a little, but the side effects were terrible. Reduced the dose of metformin. Together with diet and exercise, the drug lowered blood sugar levels by, I would say, 20%.

    Conclusion: skipping medication causes side effects.

    1. Efficiency: low

    Appointed about a month ago, recently diagnosed with type 2 diabetes. Took it for three weeks. The side effects were mild at first, but intensified so much that I ended up in the hospital. I stopped taking it two days ago and is gradually recovering my strength.

    Conclusion: individual intolerance to the active substance

    Source: diabet-lechenie.ru

    Глюкофаж или Сиофор - что лучшеMost often, with Most often, with type 2 diabetes mellitus, use Glucophage and Siofor.

    Both drugs are quite effective, so patients cannot choose which one is better.

    It is necessary to find out what medicines are similar and what is the difference between Siofor and Glucophage.

    The main difference between drugs

    To understand which is better than Glucophage or Siofor, it is recommended to learn more about the differences between the drugs. The main differences lie in the way the drugs are used.

    Difference parameters Siofor Glucophage
    Use with a lack of insulin production Can not use Can be applied
    Application frequency Several times a day Once a day (Glucophage long)
    Contraindications and side effects More contraindications More side effects

    In addition, the drugs are different in cost (Siofor is slightly more expensive). Glucophage is an analogue of Siofor, based on one active ingredient.

    About Glukofazh

    The medicine Glucophage is available in the form of tablets. The active ingredient is metformin hydrochloride. It affects glycogen synthase, insulin is produced.

    Glucophage long (analogue of Glucophage) is especially popular among diabetics, it works for a longer time. The active ingredient metformin is released from the tablet for longer (about 10 hours). They drink a pill once a day (preferably in the evening), this contributes to a lesser manifestation of side effects from the gastrointestinal tract. Nevertheless, the drug affects glucose levels no worse than Siofor.

    About GlukofazhDifference parameters

    Siofor Glucophage Use with a lack of insulin production Can not use Can be applied Application frequency Several times a day Once a day (Glucophage long) Contraindications and side effects More contraindications More side effects

    In addition, the drugs are different in cost (Siofor is slightly more expensive). Glucophage is an analogue of Siofor, based on one active ingredient.

    About Glukofazh

    The medicine Glucophage is available in the form of tablets. The active ingredient is metformin hydrochloride. It affects glycogen synthase, insulin is produced.

    Glucophage long (analogue of Glucophage) is especially popular among diabetics, it works for a longer time. The active ingredient metformin is released from the tablet for longer (about 10 hours). They drink a pill once a day (preferably in the evening), this contributes to a lesser manifestation of side effects from the gastrointestinal tract. Nevertheless, the drug affects glucose levels no worse than Siofor.

    About Glukofazh

    In addition to normalizing blood sugar levels, Glucophage helps fight obesity. When a patient undergoes a course of treatment, lipid metabolism is restored, carbohydrates are less broken down and transformed into fat deposits. The release of insulin decreases, the appetite decreases.

    It is important to stick to your diet while taking the medicine. It is allowed to consume no more than 1800 kcal per day. It is also recommended to get rid of bad habits, exercise.

    The course of treatment is 20 days (2-3 times a day, one tablet one hour before meals), then a break is taken for 2 months and the therapy is repeated. Breaks are given to avoid addiction. Before starting therapy, it is advisable to familiarize yourself with the contraindications that are indicated in the instructions and possible side effects. Price - from 122 rubles, depending on the number of tablets and the concentration of the active substance.

    About Siofor

    Release form - tablets. The active ingredient is metformin hydrochloride. Due to the use of the drug, the postprandial and basal sugar concentration decreases. Does not affect insulin production, so hypoglycemia does not develop.

    About Siofor

    The active ingredient inhibits glycogenolysis and gluconeogenesis, less glucose is produced in the liver. Intracellular production of glucogen is stimulated, lipid metabolism is normalized. Siofor affects the sensitivity of cells to insulin, insulin resistance is prevented.

    It is often recommended in the presence of excess weight, as an independent remedy or together with insulin, when a special diet and physical activity did not give the desired result.

    To avoid the development of lactic acidosis, it is recommended to exclude the use of alcoholic beverages. If a diabetic is indicated for surgery using general anesthesia, it is necessary to stop taking Siofor and continue using it 48 hours after surgery.

    Simultaneously with Siofor, medications can be prescribed to lower blood glucose. Thus, the intensity of glucose absorption increases and its concentration in the blood decreases. In type 2 diabetes, insulin therapy is sometimes prescribed, in which case the patient's well-being becomes much better.

    About Siofor

    In some cases, it is used as an independent agent, while there is no need to use other drugs. Physical activity and diet must also be followed.

    The dosage of the drug is calculated by an individually qualified specialist, taking into account the individual characteristics of the patient. The effect of the tablets appears within 30 minutes after use. Average cost from 244 rubles.

    The use of the drug helps to reduce cholesterol levels, excess weight, and prevent cardiovascular diseases. After stopping the use of Siofor, excess weight is gained again.

    Similarities

    These drugs have a lot in common. The active ingredient is the same - metformin. Diabetic complications (including cardiovascular pathologies, which are common among diabetics) are less common during treatment.

    Similarities

    Both medicines are used for the treatment and prevention of type 2 diabetes, the fight against extra pounds, and appetite suppression. For weight correction, Glucophage Long or Siofor is used by healthy people. While the treatment lasts, the effect is visible, but after the withdrawal of the pills, the weight returns again. In this case, follow a diet and exercise.

    Both medicines are strictly forbidden to take during pregnancy. Also, when taken simultaneously with contraceptives, the effectiveness of all medicines is mutually reduced and the load on the kidneys increases.

    The opinion of doctors

    Reviews of experts regarding what is better Glucophage or Siofor are ambiguous. Siofor is not addictive, but the dosage is selected individually for each patient. For people who do not suffer from diabetes, the drug really helps to reduce weight, the body begins to regulate metabolism. Glucophage has specific dosage instructions.

    The opinion of doctors

    Doctors note that both drugs have a positive effect on the body of a diabetic and are quite effective. If Siofor and Glucophage lead to indigestion, Glucophage Long. Taking this drug does not cause spikes in glucose. If the patient needs a quick result or is in prediabetes, Siofor is prescribed.

    Reviews of diabetics

    Patients claim that when Siofor is consumed, appetite decreases. The medicine does not "pass" sweet, fatty and other unhealthy foods into the body; side effects appear in the form of nausea and vomiting. Due to this, weight is reduced. It is also believed that for a quick effect, it is better to use Siofor, if time permits - Glucophage is preferred.

    Reviews of diabetics

    Patients prefer glucophage due to its efficiency and low cost. It is noted that the drug acts more gently. One of the main advantages of the drug is a decrease in appetite and a decrease in cravings for sweets.

    Thus, drugs based on metformin have a similar effect on the body, lead to the same results. To make a choice in favor of one medicine, it is recommended that you familiarize yourself with all contraindications, consult with your doctor. Diabetics should remember that for best results, the tablets must be combined with proper diet and physical activity.

    Test: to determine the risk of type 2 diabetes

    If a person cannot control their appetite during diet therapy, then the doctor may prescribe an appetite suppressant medication. For such purposes, Siofor or Glucophage are usually prescribed. Medicines are very similar in composition and therapeutic effect, but there are some differences.

    But which medicine is better? How to drink these drugs to treat obesity correctly? And what is the effectiveness of therapy with Glucophage and Siofor? Below we will look at these issues.

    Why are medicines often compared?

    Siofor and Glukofazh - what is better for diabetes mellitus, how to take medications, analogues

    Glucophage and Siofor are two drugs that are very often used to treat obesity in humans. Initially, these drugs were only used to treat type 2 diabetes, but more recently, these drugs have become widely used to treat obesity. The fact is that these drugs contain special components that can suppress appetite, so taking these drugs can be very useful in the treatment of obesity.

    In their composition and therapeutic properties, these drugs are very similar to each other. However, there are certain differences between them, so it is not surprising that these drugs are constantly being compared. Below we will consider the therapeutic features of each drug, and then we will find out which of these drugs is the most effective.

    What is Siofor?

    Siofor is a broad-spectrum medicine. It is most commonly used to treat type 2 diabetes.

    The drug does not completely cure the disease, but only temporarily restores the sensitivity of cells, so a person with diabetes should take Siofor throughout his life.

    When used, the main active ingredient is released almost immediately, and the so-called prolonged effect is absent.

    It can also be used to treat other disorders. Studies show that long-term use of Siofor gradually removes harmful cholesterol from the body, so this medicine can be used to treat heart disease that appeared against the background of an increase in cholesterol concentration. Also pills can be used for weight loss.

    In the body, the cycle "hunger-satiety" directly depends on the concentration of glucose. If there is too much of it, then the person will experience an acute feeling of hunger. At the same time, carbohydrate metabolism in the body is arranged in such a way that a person still feels hunger for a rather long time during a meal, which often leads to overeating.

    Overeating gives the body extra calories that will be converted into fat, which will lead to weight gain. When taken, the sugar concentration is automatically reduced, which leads to a feeling of satiety. Due to this, it becomes easier for a person to control food intake, and the total amount of food decreases.

    Reducing the calorie content of food leads to increased metabolism and burning of subcutaneous fat, which leads to weight loss.

    Must Read: Evalar Bio Tea for Effective Appetite Control

    Siofor and Glukofazh - what is better for diabetes mellitus, how to take medications, analogues

    Siofor is available in tablet form. The dosage and method of administration of the drug depends on many parameters, but most often this medicine is drunk 1-2 tablets 3 times a day before meals.

    This technique is needed in order to suppress appetite in advance.

    At the same time, Siofor is prescribed quite often in combination with other hypoglycemic drugs, since Siofor is well combined with many substances.

    • Studies show that with the help of Siofor, you can lose 1-3 kg per week if you follow the dosage rules.

    At the same time, you need to understand that Siofor itself does not destroy fat, but only reduces a person's appetite, which allows you to create a calorie deficit in the body, which ultimately leads to weight loss. Taking the drug makes sense only if drug therapy is combined with diet therapy and sports activities, and in case of violation of nutritional rules, the effectiveness of therapy will be rather low.

    The drug has no side effects if the rules of admission are followed, however, in case of an overdose, disorders such as nausea, vomiting, dizziness, headache, abdominal pain, and so on may occur. In case of an overdose, you must urgently stop taking the drug and consult a doctor for advice (in case of acute poisoning, you can call an ambulance). There are also diseases in which to drink

    Siofor is contraindicated:

    • Diseases of the liver and kidneys;
    • Age under 16;
    • Various disorders in which the production of insulin is completely or partially impaired (for example, type 1 diabetes);
    • Pregnancy and lactation;
    • Poor immunity and / or low hemoglobin in the blood;
    • Alcoholism;
    • Heart failure.

    Siofor and Glukofazh - what is better for diabetes mellitus, how to take medications, analogues Siofor and Glukofazh - what is better for diabetes mellitus, how to take medications, analogues Siofor and Glukofazh - what is better for diabetes mellitus, how to take medications, analogues

    What is Glucophage?

    Glucophage is also a metformin-based drug that is also used to treat type 2 diabetes. This drug can also be used to treat certain other disorders, such as obesity.

    The main distinguishing feature of Glucophage is the fact that this drug contains a large number of excipients.

    Due to this, the so-called prolonged effect is achieved - after taking metformin, it is not released immediately (as in the case of the same Siofor), but gradually over 10-12 hours.

    Therefore, Glucophage can be drunk less often. Most often, Glucophage is prescribed for the treatment of type 2 diabetes, but this medicine can also be used to treat obesity. Studies show that with the help of Glucophage, you can also lose about 1-3 kg per week.

    Since Glucophage has a prolonged effect, it can be drunk 1 tablet 2 times a day, regardless of the meal time.

    However, you need to drink the medicine every 12 hours, since the prolonged effect disappears over time, therefore, if the rules of admission are violated, the concentration of sugar in a person may increase, which will lead to increased appetite.

    Siofor and Glukofazh - what is better for diabetes mellitus, how to take medications, analogues

    Otherwise, Glucophage is very similar to all other metformin-based drugs.

    To treat obesity, you need not only to drink Glucophage, but also to adhere to a healthy lifestyle, since otherwise the effectiveness of therapy will be very low.

    Glucophage has no side effects if the dosage rules are followed and works well with other drugs to lower sugar. However, this medication is contraindicated in the following cases:

    • Type 1 diabetes and all other diseases in which there is a violation of insulin synthesis;
    • Diseases of the kidneys and liver;
    • Diseases of the cardiovascular system;
    • Alcoholism;
    • Pregnancy and lactation;
    • Age under 16.

    Which medicine is best?

    As you can see, the drugs are very similar to each other both in composition and in the therapeutic effect on the body.

    They are used to treat type 2 diabetes, but because of their potential to lower blood sugar levels, these drugs can be used as appetite suppressants, which can be useful in treating obesity.

    The effectiveness of the drugs is the same - with their help, you can lose weight by 1-3 kg per week, if you eat right, play sports and do not have bad habits. Both drugs have the same contraindications, side effects, and compatibility with other drugs.

    However, in practice, doctors most often give preference to Glucophage. And that's why:

    • In the treatment of obesity, it is very important to reduce a person's appetite, since many people stop eating dietary foods due to the fact that they remain hungry after eating a dietary meal. Siofor and Glukofazh - what is better for diabetes mellitus, how to take medications, analogues
    • To cope with appetite, a doctor may prescribe medications to lower blood sugar, as they can dull hunger, allowing a person to control their diet.
    • At the same time, it is important to understand that Glucophage, due to additional components, has a prolonged effect, and appetite decreases by 10-12 hours after taking the medication.
    • Siofor is deprived of this advantage, which reduces appetite only immediately after taking it, and after 20-30 minutes the effect of suppressing appetite disappears.
    • Therefore, it is much easier for a person to drink Glucophage 2 times a day, regardless of mealtime, than to drink Siofor several times right before meals.
    • That is why Glucophage, on average, is prescribed more often than Siofor. However, it should be understood that Siofor is also an excellent medicine for suppressing appetite - it is just not very convenient to drink it, however, if the rules of admission are followed, the therapeutic effect will be absolutely the same.

    Siofor or Glucophage - what do doctors and patients think?

    Let's now find out what ordinary patients and experienced doctors think about the use of Siofor and Glucophage.

    Anton Verbitsky, nutritionist

    “If a person ate a lot, and then suddenly went on a diet, then it will be very difficult for him. At the same time, it will be difficult for him even in the case of diets that involve a transitional period, when a person can eat his usual dishes.

    The main problem lies not so much in diet (after all, in most cases, making a dietary plan is actually not that difficult), as in the problem of high appetite, since in the case of eating dietary products, it is very difficult for a person to get enough. Fortunately, there are a large number of appetite suppressants available today.

    I usually prescribe Glucophage to my patients, since it works for 12 hours, so a person needs to eat one tablet in the morning and one tablet in the evening to cope with their appetite.

    However, in the case of very severe obesity, I can prescribe an additional drink of 1 tablet of Siofor, which does not have a prolonged effect, but which immediately reduces the concentration of sugar in the body, which will allow a severely obese person to cope with his appetite.

    Be sure to read: How to take BCAA correctly and effectively?

    1. Siofor and Glukofazh - what is better for diabetes mellitus, how to take medications, analogues

    Antonina Petrova, pensioner

    “At the age of 70, I started having problems with blood sugar. The excess sugar also made me overweight. The doctor first prescribed Siofor so that I would drink 1 tablet before each meal. In 2 weeks I lost about 5 kg.

    However, I was very uncomfortable drinking this medicine before every meal - and I told the doctor about it. The doctor, having thought, prescribed me a drug called Glucophage instead of Siofor. I drank it for also 2 weeks in the morning after waking up and in the evening before dinner. And during this time, I also lost 5 kg.

    It seems to me that the therapeutic effect of these drugs is the same, but Glucophage is still more convenient to drink. "

    Petr Alekseev, worker

    “After being transferred to another workshop, my physical activity decreased. Because of this, I began to appear overweight. At first I tried to adjust the diet myself, but nothing good came of it. Then I consulted a dietitian.

    He drew up a dietary plan for me, with the help of which I should lose weight by about 8-9 kg per month. However, the dietary restrictions were so severe that I could not sit on this diet for long. When the doctor found out that I had given up the diet, he prescribed Glucophage to me to weaken my appetite. And you know - it helped.

    Drinking this medicine is very simple, and its effect appears already after 1-2 hours after taking. Many thanks to the doctor. "

    Conclusion

    Let's summarize. Glucophage and Siofor have a very similar composition, so these drugs have almost the same therapeutic effect.

    However, Glucophage has a prolonged effect, while Siofor is devoid of this effect, therefore Glucophage is prescribed more often on average. It should be understood that in all other respects these drugs are very similar.

    They are good at suppressing appetite, which is why they are also used to treat excess weight.

    With the help of tablets, you can lose weight by 1-3 kg per week if you follow the dosage rules. These medicines are well absorbed, but they are contraindicated in some diseases and during pregnancy.

    A source: https://pohudete.ru/siofor-ili-glyukofazh-chto-luchshe.html

    Siofor

    Siofor 500 contains 500 mg metformin hydrochloride (active substance), and povidone , silica , magnesium stearate , macrogol (additional substances).

    Siofor 850 contains 850 mg metformin hydrochloride and similar additional substances. Siofor 1000 contains 1000 mg metformin hydrochloride and similar additional substances.

    Release form

    Siofor is available in the form of white oblong tablets. They are covered with a shell and have a notch for division on both sides. Packed in blisters of 15 pcs.

    pharmachologic effect

    Siofor is a hypoglycemic drug that belongs to the group biguanides ... The medicine has an antidiabetic effect.

    It helps to inhibit the absorption of glucose from the gastrointestinal tract, increases insulin sensitivity of peripheral tissues, slows down the process glucogenesis ... Under the influence of the drug, the utilization of glucose by the muscles is activated.

    Siofor also has a positive effect on lipid metabolism due to lipid-lowering effects and on the coagulation system due to fibrinolytic effects.

    The drug reduces blood glucose levels, helps to reduce body weight in people who are sick diabetes mellitus , reduces appetite.

    Pharmacodynamics and pharmacokinetics

    The maximum concentration of the drug is reached 2.5 hours after oral administration. If food is taken simultaneously with the drug, absorption slows down and decreases. In healthy people, bioavailability is about 50-60%.

    The active substance almost does not bind to plasma proteins.

    The drug is excreted unchanged in the urine. The half-life after oral administration is approximately 6.5 hours.

    If the patient has reduced renal function, the half-life increases, therefore, the concentration in the plasma increases metformin .

    Indications for use

    Siofor tablets are indicated for use in the treatment of type 2 diabetes mellitus, especially if the patient has obesity , and diet and physical activity do not sufficiently compensate for metabolic processes.

    Contraindications

    Contraindications for taking the drug are as follows:

    • hypersensitivity;
    • diabetes first type ;
    • diabetic ketoacidosis ;
    • diabetic precoma , coma ;
    • cessation of endogenous insulin secretion in patients with type 2 diabetes mellitus;
    • renal, hepatic, respiratory failure;
    • myocardial infarction in the acute phase;
    • severe infectious diseases;
    • trauma and surgery;
    • hypoxic conditions;
    • enhanced decay processes in the body (tumors, etc.);
    • lactic acidosis ;
    • chronic alcoholism;
    • diet with a strictly limited calorie content (less than 1000 calories per day);
    • childhood;
    • the period of pregnancy, breastfeeding.

    Side effects

    When taking Siofor, the following side effects are possible:

    • In the system of the digestive tract: at the beginning of treatment, a metallic taste in the mouth, impaired appetite, vomiting, abdominal pain, diarrhea may be felt. In the course of treatment, these side effects gradually disappear.
    • In the hematopoietic system: very rarely can develop megaloblastic anemia .
    • Skin: in rare cases, they develop allergic reactions .
    • In rare cases, the manifestation of lactic acidosis .

    Instruction for Siofor (Method and dosage)

    In general, the tablets are taken orally, they need to be washed down with plenty of water, not chewed. The dosage is prescribed by the attending physician depending on what blood sugar level is found in the patient.

    The instruction for Siofor 500 is as follows: initially 1-2 tablets are prescribed per day, gradually the daily dose is increased to three tablets. The largest dose of the drug per day is six tablets.

    If a person takes more than one tablet per day, it is necessary to divide them into several doses. Do not increase the dosage without first consulting a doctor.

    The duration of treatment is determined only by a specialist.

    Instructions for the use of Siofor 850 are as follows: initially, taking the drug begins with one tablet. Gradually, the dose can be increased to 2 tablets. You can take no more than 3 tablets per day.

    If more than one tablet is taken per day, you need to divide them into several doses. Do not increase the dosage without first consulting a doctor.

    The duration of treatment is determined only by a specialist.

    The instruction for Siofor 1000 is as follows: the reception starts with 1 tablet, you can take no more than 3 tablets per day. Sometimes it is necessary to combine the intake of this drug with insulin. You can not use Siofor for weight loss without first consulting a doctor.

    Taking the drug with polycystic ovary is possible only after the approval of such treatment by a doctor.

    Overdose

    During the studies, there was no manifestation of hypoglycemia even if a dose was taken that exceeded the daily dose by 30 times.

    Overdose can lead to lactic acidosis ... Symptoms of this condition are vomiting, diarrhea, weakness, rapid breathing, loss of consciousness. In this case, hemodialysis is performed.

    But often the symptoms can be eliminated by taking glucose or sugar.

    Interaction

    If Siofor is taken simultaneously with other hypoglycemic drugs, NSAIDs, MAO inhibitors, fibrates, ACE inhibitors, insulin, it is important to carefully and regularly monitor glucose levels. In this case, the hypoglycemic properties of Siofor may increase.

    The effectiveness of the drug may decrease if it is taken in combination with thyroid hormones, glucocorticosteroids, progesterone , estrogen , thiazide diuretics, sympathomimetics, as well as nicotinic acid ... In this case, it is important to control the level of glycemia, correction of Siofor doses is possible.

    Simultaneous treatment cimetidine may increase the likelihood of manifestation lactic acidosis .

    Terms of sale

    The tablets are dispensed with a doctor's prescription.

    Storage conditions

    It is necessary to store the drug at a temperature not exceeding 25 degrees Celsius. Keep the drug out of the reach of children.

    Shelf life

    Can be stored for 3 years.

    special instructions

    During the period of drug treatment, it is necessary to very carefully monitor the functioning of the patient's kidneys.

    If a radiological examination is planned, the drug intake must be suspended before the examination and not to take the drug for another two days after the examination, since the administration of contrast can provoke renal failure .

    Reception Siofor must be stopped two days before the planned surgery, which will be performed under general anesthesia. Treatment can continue two days after surgery.

    You should not combine the use of this remedy with those drugs that increase hypoglycemic effect .

    The medicine is carefully used to treat the elderly who have already turned 65 years old.

    It is recommended to control the level blood lactate Twice a year. If Siofor is taken in combination with other drugs that lower sugar levels, the person's ability to drive transport may be impaired.

    Synonyms

    Glucophage , Dianormet , Glucophage XR , Metfogamma , Diaformin , Metformin Hexal .

    Analogs

    Matching ATX level 4 code: Siofor and Glukofazh - what is better for diabetes mellitus, how to take medications, analoguesBagomet Siofor and Glukofazh - what is better for diabetes mellitus, how to take medications, analoguesDiaformin Siofor and Glukofazh - what is better for diabetes mellitus, how to take medications, analoguesMetformin Siofor and Glukofazh - what is better for diabetes mellitus, how to take medications, analoguesFormetin Siofor and Glukofazh - what is better for diabetes mellitus, how to take medications, analoguesGlyformin Siofor and Glukofazh - what is better for diabetes mellitus, how to take medications, analoguesGlucophage Long Siofor and Glukofazh - what is better for diabetes mellitus, how to take medications, analoguesGlucophage

    Analogs are sometimes used as substitutes for Siofar. The following analogs are used: Metformin , Metfogamma , Formetin , Glucophage ... They contain a similar active ingredient, so their effect on the body is similar. But only a specialist can replace the drug with analogues.

    Which is better: Siofor or Glucophage?

    Glucophage contains metformin hydrochloride as an active ingredient and is used both as mono therapy for type 2 diabetes mellitus and in the process of complex treatment. However, this drug, like Siofor, is not used solely for weight loss. Therefore, the question of what is best for losing weight is incorrect in this case.

    Metformin or Siofor - which is better?

    Both drugs belong to the group of oral hypoglycemic drugs and can be used interchangeably after a doctor's approval. The doctor determines the feasibility of using one or another drug on an individual basis.

    For children

    To date, there are no clear clinical data, so the drug is not used to treat children.

    With alcohol

    Poor alcohol compatibility. Available lactic acidosis when treating Siofor and when taking alcohol. Reviews indicate the poor health of people who combined alcohol and this drug. There is also an increased risk of hypoglycemia.

    Slimming

    The drug effectively reduces blood glucose, and, first of all, it is prescribed to people with diabetes who are obese. However, doctors do not support those who use Siofor exclusively for weight loss. Nevertheless, reviews of Siofor for weight loss indicate that, first of all, the drug reduces the desire to eat sweets.

    Those who unsubscribe on the forum about how Siofor 500 or Siofor 850 and weight loss are combined note that weight loss occurs very quickly, especially in combination with a decrease in calorie intake and physical activity. However, those who take diet pills also have side effects - colic , fermentation in the stomach frequent and loose stools nausea .

    But if a person still decides to try this method of weight loss, clear instructions on how to take Siofor for weight loss are needed. In this case, a drug is used with a minimum dose of the active ingredient - 500 mg. You need to take the tablets either during meals or before meals.

    If the diet is followed while taking the drug, you need to limit yourself to one tablet per day.

    You can not take drugs if heavy loads are coming, combine it with other drugs for weight loss, laxatives , diuretic drugs .

    The course of treatment should be discontinued at a high temperature, pronounced disorders of the gastrointestinal tract. It is not recommended to take the drug for more than 3 months.

    During pregnancy

    Pregnancy is a contraindication for taking Siofor. The drug is contraindicated during pregnancy. When planning pregnancy, drug treatment is also not recommended.

    Reviews about Siofor

    The doctors' comments on Siofor 1000, 850, 500 are mostly positive, but experts emphasize that the drug should be taken exclusively by patients with diabetes mellitus, and not healthy people who are losing weight. The drug helps to effectively restore normal sugar levels and, moreover, people with diabetes who take Siofor 850 or the drug in other doses, notice a decrease in weight.

    On the Internet, you can find many reviews of those who have lost weight using this tool, which claim that when it is taken, appetite really decreases.

    But the reviews on Siofor 500 for diabetes, as well as the opinions of those who took it for weight loss, agree that after stopping the course of treatment, the weight usually returns quickly. The fact that the tablets are affordable is also noted.

    However, there are also many negative reviews about the side effects that develop in the course of such therapy. In particular, we are talking about problems in the functioning of the liver, pancreas, intestines, stomach.

    Siofor's price where to buy

    • The price of Siofor 500 mg is approximately 240-260 rubles.
    • You can buy Siofor 850 mg at a cost of 290 - 350 rubles.
    • Siofor's price of 1000 mg averages 380 - 450 rubles.

    A source: https://medside.ru/siofor

    Glucophage or siofor: which is better and what is the difference (difference between compositions, doctors' reviews)

    With type 2 diabetes, doctors often prescribe drugs such as Glucophage or Siofor. They both show efficacy in this condition. Thanks to these medications, cells become more sensitive to the effects of insulin. Such drugs have advantages and disadvantages.

    Characteristics of Glucophage

    This is a drug that has a hypoglycemic effect. Release form - tablets, the active ingredient of which is metformin hydrochloride. It activates the production of insulin by affecting glycogen synthase, and also has a beneficial effect on lipid metabolism, reducing the concentration of cholesterol and lipoproteins.

    Siofor and Glukofazh - what is better for diabetes mellitus, how to take medications, analogues

    With type 2 diabetes, doctors often prescribe drugs such as Glucophage or Siofor.

    In the presence of obesity in a patient, the use of the drug leads to an effective decrease in body weight. It is prescribed for the prevention of type 2 diabetes in patients who have a predisposition to its development. The main component does not affect the production of insulin by the cells of the pancreas, so there is no risk of hypoglycemia.

    Glucophage is prescribed for type 2 diabetes, especially for obese patients, if physical activity and diet have been ineffective. You can also use it with other drugs with hypoglycemic properties, or with insulin.

    Contraindications:

    • renal / hepatic impairment;
    • diabetic ketoacidosis, precoma, coma;
    • severe infectious diseases, dehydration, shock;
    • diseases of the cardiovascular system, acute myocardial infarction, respiratory failure;
    • type 1 diabetes mellitus;
    • adherence to a low-calorie diet;
    • chronic alcoholism;
    • acute ethanol poisoning;
    • lactic acidosis;
    • surgical intervention, after which insulin therapy is prescribed;
    • pregnancy;
    • excessive sensitivity to components.

    In addition, it is not prescribed 2 days before and after the implementation of a radioisotope or X-ray examination, in which an iodine-containing contrast was used.

    Adverse reactions include:

    • nausea, vomiting, diarrhea, loss of appetite, abdominal pain;
    • violation of taste;
    • lactic acidosis;
    • hepatitis;
    • rash, itching.

    The simultaneous reception of Glucophage with other hypoglycemic agents can cause a decrease in concentration, so you need to drive a car and complex mechanisms with caution.

    Analogs include: Glucophage Long, Bagomet, Metospanin, Metadien, Langerin, Metformin, Glyformin. If there is a need for prolonged action, it is recommended to use Glucophage Long.

    Siofor's characteristic

    It is a drug that helps lower blood glucose levels. Its main component is metformin. It is made in the form of tablets. The drug effectively lowers postprandial and basal sugar concentration. It does not cause hypoglycemia because it does not affect insulin production.

    Metformin inhibits glycogenolysis and gluconeogenesis, as a result of which the production of glucose in the liver decreases and its absorption improves. Thanks to the action of the main component on glycogen synthetase, intracellular glycogen production is stimulated. The drug normalizes impaired lipid metabolism. Siofor reduces the absorption of sugar in the intestine by 12%.

    A medication is indicated for patients with type 2 diabetes mellitus if diet and exercise have not brought the desired effect. It is especially recommended for overweight patients. The drug is prescribed both as a single drug and in combination with insulin or other diabetes medications.

    Siofor and Glukofazh - what is better for diabetes mellitus, how to take medications, analogues

    Siofor is a drug that helps lower blood glucose levels.

    Contraindications include:

    • diabetic ketoacidosis and precom;
    • renal / hepatic impairment;
    • lactic acidosis;
    • type 1 diabetes;
    • recent myocardial infarction, heart failure;
    • a state of shock, respiratory failure;
    • impaired renal function;
    • severe infectious diseases, dehydration;
    • the introduction of a contrast agent containing iodine;
    • adhering to a diet that consumes foods low in calories;
    • pregnancy and lactation;
    • individual intolerance to the components of the medication;
    • age up to 10 years.

    During Siofor therapy, alcohol consumption should be excluded, because this can lead to the development of lactic acidosis - a severe pathology that occurs when lactic acid accumulates in the bloodstream.

    Adverse reactions occur infrequently. These include:

    • nausea, vomiting, decreased appetite, diarrhea, abdominal pain, metallic taste in the mouth;
    • hepatitis, increased activity of liver enzymes;
    • hyperemia, urticaria, pruritus;
    • violation of taste;
    • lactic acidosis.

    Siofor and Glukofazh - what is better for diabetes mellitus, how to take medications, analogues

    While taking Siofor, a side effect in the form of nausea may appear.

    2 days before the operation, during which general anesthesia, epidural or spinal anesthesia will be used, it is necessary to stop taking pills. Their use is resumed 48 hours after the surgery. To ensure a stable healing effect, Siofor should be combined with daily exercise and diet.

    Analogs of the drug include: Glucophage, Metformin, Glyformin, Diaformin, Bagomet, Formetin.

    Comparison of Glucophage and Siofor

    Similarity

    The drugs include metformin. They are prescribed for type 2 diabetes in order to normalize the patient's condition. Medicines are produced in the form of tablets. They have the same indications for use and side effects.

    Siofor and Glukofazh - what is better for diabetes mellitus, how to take medications, analogues

    Glucophage is available in tablet form.

    What is the difference

    Medicines have slightly different restrictions on their use. Siofor cannot be used if there is insufficient insulin production in the body, but Glucophage is possible. The first drug needs to be used several times a day, and the second one - once a day. They also differ in price.

    Which is cheaper

    Siofor's price - 330 rubles, Glucophage - 280 rubles.

    Which is better - Glucophage or Siofor

    When choosing between drugs, the doctor takes into account many factors. Glucophage is prescribed more often, because it does not irritate the intestines and stomach as much.

    With diabetes

    Taking Siofor does not lead to addiction to lowering blood sugar, and when using Glucophage, there are no sharp jumps in blood glucose levels.

    Siofor and Glukofazh - what is better for diabetes mellitus, how to take medications, analogues

    Taking Siofor does not lead to an addictive lowering of blood sugar.

    Slimming

    Siofor effectively reduces weight because suppresses appetite and speeds up metabolism. As a result, a diabetic patient can lose several pounds. But this result is observed only while taking the medication. After its cancellation, the weight quickly regains.

    Effectively reduces weight and Glucophage. With the help of the drug, the disturbed lipid metabolism is restored, carbohydrates are less broken down and absorbed. Decreased insulin release leads to decreased appetite. Cancellation of the drug does not lead to rapid weight gain.

    1. Siofor and Glucophage for diabetes and weight loss
    2. Metformin interesting facts
    3. Which of the preparations Siofor or Glucophage is better for diabetics?

    Reviews of doctors

    Karina, endocrinologist, Tomsk: “Glucophage is prescribed for diabetes and obesity. It helps to effectively get rid of excess weight without causing harm to health, it is good for lowering blood sugar. Some patients may have diarrhea while taking the drug. "

    Lyudmila, endocrinologist: “I often prescribe Siofor to my patients with type 2 diabetes, conditions of prediabetes. For many years of practice, he proved his effectiveness. Sometimes flatulence and abdominal discomfort may develop. These side effects go away after a while. "

    Patient reviews about Glukofazh and Siofor

    Marina, 56 years old, Oryol: “I have been suffering from diabetes for a long time. I have tried many different drugs that are designed to lower blood glucose. At first, they helped, but after getting used to it, they became ineffective. A year ago, the doctor prescribed Glucophage. Taking the medication helps to keep the sugar level in the norm, and no addiction has arisen during this time. "

    Olga, 44 years old, Inza: “Siofor was appointed by an endocrinologist several years ago. The result appeared after 6 months. My blood sugar levels returned to normal and my weight decreased slightly. At first, there was such a side effect as diarrhea, which disappeared after the body got used to the drug. "

    A source: https://SayDiabetu.net/lechenie/tradicionnaya-medicina/drygie-lekarstva/glyukofazh-ili-siofor/

    What is better to take for diabetes siofor or glucophage

    There are many medications that are designed to normalize blood glucose levels. Metformin or Siofor, which is better and more effective? A diabetic may have to choose which medication to buy and what the difference is.

    It should be noted that the tablets Metformin Teva, Glukofazh, Siofor are included in the group of drugs-biguanides. Moreover, if you pay attention to the composition of the drug, you can see that the main active ingredient is the same substance.

    The active substance metformin is a part of many antihyperglycemic drugs. It is an active ingredient from the third generation biguanide group and helps to lower blood glucose levels.

    An antidiabetic agent inhibits the process of gluconeogenesis, the transport of electrons in the respiratory chains of mitochondria. Stimulation of glycolysis occurs, cells begin to better absorb glucose, and its absorption by the intestinal walls decreases.

    Indications for the use of a medicinal substance?

    One of the advantages of the active ingredient is that it does not provoke a sharp decrease in glucose. This is due to the fact that Metformin is not a stimulating substance for the secretion of the hormone insulin.

    The main indications for the use of drugs based on metformin are:

    • the presence of metabolic syndrome or manifestations of insulin resistance;
    • as a rule, in the presence of insulin resistance, obesity develops rapidly in patients, thanks to the effects of Metformin and adherence to a special diet, gradual weight loss can be achieved;
    • if there is a violation of glucose tolerance;
    • scleropolycystic ovary develops;
    • non-insulin-dependent diabetes mellitus as monotherapy or as part of complex treatment
    • insulin-dependent diabetes mellitus in conjunction with insulin injections.

    When comparing metformin-based tablets with other sugar-reducing drugs, the following main advantages of metformin should be highlighted:

    1. Its effect on reducing insulin resistance in a patient. Metformin hydrochloride can increase the sensitivity of cells and tissues to glucose produced by the pancreas.
    2. Taking the medicine is accompanied by its absorption by the organs of the gastrointestinal tract. Thus, a slowdown in the absorption of glucose by the intestine is achievedꓼ
    3. Promotes inhibition of liver gluconeogenesis, the so-called glucose replacement process.
    4. It helps to reduce appetite, which is especially important for overweight diabetics.
    5. It has a positive effect on cholesterol levels by lowering bad cholesterol and increasing good.

    The advantage of drugs based on metformin is also the fact that they help to neutralize the process of fat peroxidation.

    Adverse reactions and possible harm from metformin

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    • Despite the number of positive properties of the substance metformin hydrochloride, its incorrect use can bring irreparable harm to the human body.
    • That is why healthy women who are looking for easy ways to lose weight should think about whether it is worth taking such a medicine?
    • The tablet is also actively used as a drug for weight loss.
    • The main adverse reactions that can occur as a result of taking metformin hydrochloride include:
    • the occurrence of various problems with the gastrointestinal tract, especially symptoms such as nausea and vomiting, diarrhea, bloating and soreness of the abdomen,
    • the medicine increases the risk of developing anorexia,
    • a change in taste is possible, which manifests itself in the appearance of an unpleasant taste of metal in the oral cavity,
    • a decrease in the amount of vitamin B, which makes it necessary to additionally take medications with medicinal additives,
    • manifestation of anemia,
    • with a significant overdose, there may be a risk of developing hypoglycemia,
    • problems with the skin, if there is an allergic reaction to the drug taken.

    At the same time, Metformin, Siofor or other structural generics can cause the development of lactic acidosis if a significant accumulation of its amount occurs in the body. Such a negative manifestation most often appears with poor kidney performance.

    It should be noted that it is forbidden to take a medicinal substance if the following factors are identified:

    1. Acidosis in acute or chronic forms.
    2. Girls during the period of gestation or breastfeeding.
    3. Patients of retirement age, especially after sixty-five years.
    4. Intolerance to the component of the drug, since severe allergies may develop.
    5. If the patient is diagnosed with heart failure.
    6. With a previous myocardial infarction.
    7. If hypoxia occurs.
    8. During dehydration of the body, which can also be caused by various infectious pathologies.
    9. Excessive physical labor.
    10. Liver failure.

    In addition, a hypoglycemic agent negatively affects the gastric mucosa.

    It is forbidden to take the medicine in the presence of diseases of the organs of the gastrointestinal tract (ulcer).

    Is there a difference between medications?

    What is the difference between the drugs Metformin, Glyformin, Siofor for diabetes? Is one medicine different from another? Often, patients are forced to make a choice: Glucophage or Siofor, Glucophage or Metformin, Siofor or Metformin, and so on. It should be noted that a significant difference lies only in the name of the medications.

    As already indicated above, the substance metformin hydrochloride is used as the main active ingredient in the composition of such medicines. Thus, the effect of taking these drugs should be the same (when using the same dosages). IN

    The difference may consist in additional components, which are also included in the tablet formulations. These are various excipients.

    When buying, you need to pay attention to their content - the fewer additional components, the better.

    In addition, the attending physician may recommend taking a specific medication, depending on the individual characteristics of the patient's body.

    For example, Siofor 500 has the following composition:

    • the main component is metformin hydrochloride,
    • excipients - hypromellose, povidone, magnesium stearate, titanium dioxide, macrogol 6000.

    The drug Glucophage (or Glucophage Long) contains the following chemical components:

    • active ingredient - metformin hydrochloride,
    • hypromellose, povidone, magnesium stearate are used as additional components.

    Thus, if there is a choice between Siofor or Glucophage for type 2 diabetes mellitus, the second option is better suited in terms of chemical composition, with fewer components.

    When choosing a medicine, one should also take into account such a factor as the cost of a medicine. Often, foreign counterparts have a price several times higher than our domestic drugs.

    As practice shows, the effect of their reception is no different.

    To date, Metformin tablets are the most budgetary option among the medical products that contain metformin hydrochloride.

    If a diabetic has doubts about anything and does not know whether it is possible to replace one drug with another, you should consult your doctor. A medical specialist will be able to explain the difference between several medical analogs, and also tell why such a drug is suitable for a particular person.

    Glucophage or Siofor - what is evidenced by the instructions for use?

    1. Medicines Glukofazh and Siofor are structural analogs.
    2. Thus, the effect of their use should be manifested equally.
    3. Sometimes the attending physician offers his patient a list of analog tablets with the option to purchase one of them.
    4. If such a situation arises, the following factors should be considered:
    1. The medicine should be cheaper.
    2. If possible, have fewer additional components.
    3. Differences may lie in the list of contraindications and side effects.

    For comparison, it is better to use the official instructions for the use of medications, and then choose which drug is more suitable.

    Metformin, Glucophage 850 differ from Siofor in the following characteristics:

    1. Glucophage 850 has a greater number of adverse reactions manifested. That is why, some consumer reviews indicate that the drug did not suit them.
    2. The comparison shows that there are more contraindications and cases when Siofor cannot be taken (in contrast to Glucophage with Metformin).
    3. The price of Glucophage is slightly higher, in this matter Siofor is better.

    It should be noted that if a medical specialist prescribes the use of prolonged-release tablets, then the cost of the drug increases significantly. For example, Glucophage Long will cost about three hundred rubles with a minimum dosage.

    The opinion of medical specialists is that such drugs are good at lowering elevated blood sugar levels, neutralizing the manifestation of resistance to the hormone insulin and helping to normalize good cholesterol. Tablets can be replaceable, as a result of which the patient can choose the option that is more optimal for him.

    • What hypoglycemic agents are most effective is described in the video in this article.
    • diabetik.guru

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    Metformin - analogues

    Metformin hydrochloride appeared on the pharmaceutical market in 1957, and until now this hypoglycemic drug is a recognized leader in the treatment of type 2 diabetes mellitus, including those complicated by obesity. As an active ingredient, metformin increases the sensitivity of cells to insulin. Derivatives of the drug Metformin are natural substances obtained from plants:

    • French lilac;
    • goat rue (goat's rue).

    According to modern scientific research, the drug Metformin is also effective in the treatment of certain types of oncology (mainly those associated with diabetes) and fatty liver disease.

    How to replace Metformin?

    Sometimes patients, believing that the treatment process is taking place without significant results, are interested in how Metformin can be replaced. Let's try to find out what analogs Metformin tablets have and how effective they are in treating diabetes.

    Popular substitutes for Metformin

    • Glucophage;
    • Siofor;
    • Metfogamma;
    • Hexal;
    • Formetin.

    All of them also contain a similar active substance, from which the logical conclusion follows that the drugs have a similar effect on the body, and, accordingly, have the same indications, contraindications for use and methods of administration.

    Which is better - Siofor or Metformin?

    Siofor, like Metformin, is an oral drug with hypoglycemic effects. Siofor is a product of the German pharmaceutical company BERLIN-CHEMIE. Siofor and Metformin tablets are considered a good alternative to insulin injections, provided that treatment is started on time.

    Which is better - Metformin or Glucophage?

    Glucophage contains metformin hydrochloride as an active ingredient, and is also taken in type 2 diabetes mellitus as a mono-agent and in complex therapy. A variety of the drug Glucophage-Long provides an extended period of action.

    Studies have shown that Glucophage is two times less likely to cause disorders of the digestive system than Metformin. But, if we compare the two pharmaceuticals in terms of price, then the cost of the Glucophage-Long drug is much higher.

    Based on the foregoing, it can be concluded that synonymous medicines can replace each other, but this requires the appointment of a specialist. But the lack of the desired effect is most often explained by:

    • violations when taking drugs (regimen, dose or diet);
    • the need to use metformin-containing drugs in combination with a group of drugs that improve their action.

    Other Metformin analogues

    1. Below are the means that can successfully replace the drug Metformin.
    2. Vijar
    3. It is a dietary supplement that lowers blood glucose and cholesterol levels, activates the immune system and is considered an excellent means of preventing viral and bacterial infections.
    4. BAA Spirulina
    5. Helps in the fight against diabetes mellitus and other metabolic disorders, as well as overweight.
    6. Glucoberry
    7. Biologically active substance used to reduce the risk of complications from diabetes.
    8. Glucosil
    9. A drug used to correct body functions in type 1 and 2 diabetes mellitus and to optimize metabolic processes.
    10. Guarem
    11. A drug taken for poorly controlled diabetes and obesity, when the transition to insulin therapy is not desirable.
    12. Midona
    13. A drug used for insulin-dependent and non-insulin-dependent diabetes mellitus, metabolic disorders of other substances in the body and severe obesity.

    A source: https://diabet.glivec.su/chto-luchshe-prinimat-pri-diabete-siofor-ili-gljukofazh/

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