DHEA (DHEA) preparations - means to extend the youth

Modern pace of life, poor ecology, poor-quality food, stress, as well as desire as long as possible to be young, healthy, strong and beautiful, make a person look for additional sources of substances and energy necessary for the body. That is why millions of people around the world resort to the help of all sorts of dietary bids that replenish the deficiency of vitamins, minerals, amino acids and other component human body for the normal functioning. We'll talk about one of them today.

We present to your attention to the means to extend the youth, the normalization of hormonal balance, reducing the fat and increase muscle mass of the body, strengthening immunity, increasing the strength of the bones, improve the condition of the skin and hair - the DHAA preparation. In this article, you will learn what the DHAA is responsible for which it is necessary to take drugs with this hormone, which leads the lack and excess of this substance, and what DHEA is better in the opinion of experts and simple consumers.

What is DHEA?

DHEA (dehydroepiyndrosterone, DHEA) is a steroid hormone responsible for regulating the majority of the most important processes occurring in the human body. It is a substrate (the basis for transformation) of such hormones as testosterone, dehydrogenousosterone and estrogen, affecting not only the reproductive system, but also for the general condition of a person (physical and emotional).

In the human body, DHEA is produced mostly in adrenal glands, and in less - in the seeds, ovaries and brain. The amount of synthesized hormone changes over the course of life. As studies show, the concentration of hormone in the human body remains normal until 20-25 years. In 50 years in most people, the DHEA level is already less than half of the norm, and in 70 - no more than 20%.

DHEA benefit

Together with the reduction of DHEA, the production of testosterone and estrogen decreases, which leads to a deterioration in the state and the emergence of age-related changes in the body. To prevent or slow them down, it is recommended to take preparations containing dehydroepiyndrosterone, the reviews about which you will find at the end of the page.

Reception of DHEA allows you to:

  • normalize the level of hormones, facilitate the state of menopause, normalize the menstrual cycle in women, eliminate the symptoms of the crisis in men, and also help improve the state with other hormonal disorders;
  • reduce the risk of cardiovascular diseases such as atherosclerosis, endothelial dysfunction and metabolic syndrome;
  • slow down the aging of the body (both both external and internal);
  • strengthen the sensitivity to insulin, reduce the risk of diabetes;
  • recycle unnecessary fat deposits into energy, reduce overweight without feeling fatigue and decline, normalize appetite (this is important, since hormonal failures can lead not only to obesity, but also to consequences - anorexia, dystrophy, etc.);
  • prevent the destruction of muscle tissue, accelerate its growth and development, for which this hormone is popular among athletes and bodybuilders;
  • reduce the risk of oncological diseases;
  • increase bone strength, increase the activity of osteoblasts, prevent osteoporosis;
  • improve skin and hair hydration;
  • strengthen immunity, weakened by transferred diseases, surgical interventions, etc.;
  • eliminate chronic fatigue, disturbing and depressive states, improve mental activity, protect the brain from a number of degenerative diseases;
  • Reduce the likelihood of AIDS disease in infected people (the presence of this property is confirmed by studies of the Texas Houston Institute of Immunology).

Lack and excess DHEA

Lack of DHEA, reviews about preparations with which you can read on our website manifests itself hormonal disorders, deterioration of well-being, mood and irritability. But since these symptoms can signal not only about the deficit of the Hormone of dehydrogenostosterone, but also about a number of other diseases, to determine the level of dehydrogenousosterone, it is necessary first of all to appeal to the therapist, and pass the blood test on DGEA-C. This analysis is recommended to hand over an empty stomach (on the day of blood delivery is possible only water), a few days before the delivery, refusing the use of oily foods, alcohol-containing beverages, tobacco and reception of any hormonal drugs. You must inform your doctor about the latter.

When the dehydrogenosterone hormone deficiency is detected, the specialist will recommend to acquire capsules or DHEA tablets to fill it. The lack of DHEA can provoke:

  • violation of the regulation of expansion and narrowing vessels, an increase in the risk of hypertension, ischemic heart disease, atherosclerosis, diabetes;
  • worsening memory, the emergence and development of degenerative diseases of the brain, depression, anxiety, mental disorders;
  • launch of irreversible processes of premature aging of the body;
  • Reducing the protective forces of the body, raising the risk of developing oncological, immune and other dangerous diseases;
  • deterioration of metabolic processes, obesity;
  • muscular dystrophy;
  • Hormonal imbalance.

Excess hormone, as studies have shown, does not carry meaningful toxic and side effects. It is known that since the testosterone hormone synthesis, with a long-term reception of DHEA drugs, in high dosage in women, hair growth on face and body can increase. In men, due to an increase in estrogen, breast volume may increase. In addition, the overabundance of the hormone enhances the production of skin salts, and provokes the formation of acne and inflammation on the skin, and also leads to irritability and fatigue. There are no more serious side effects from the hormone overabr.

Why and when can you take DHEA?

The use of DHEA is necessary to replenish the lack of this hormone, and to help in disease therapy associated with it. In addition, the drug DHEA can be appointed:

  • with autoimmune diseases, to increase immunity after suffering serious diseases, when infected with AIDS and HIV;
  • To normalize adrenal operations;
  • To improve the state of the elderly, the slowdowns of age-related changes;
  • To increase the density of bones, combat osteoporosis, reducing the risk of fractures in the elderly;
  • To improve mental activity and psycho-emotional state.

The best vitamins DHEA.

There is a huge amount of preparations with dehydrootestosterone, and when choosing many people have a question - what about them better? In order to make it easier to choose, we have allocated 3 drugs, which, according to experts and consumers, occupy a leading position among all Badov from DHE (feedback on each of them you can look in the card of the relevant product). In Top-3, they entered:

Natrol DHEA 10 MG 30 Tab

DBEA 10 mg of 30 tablets with low dosage of active substance, recommended for preventing dehydrootestosterone deficiency, deceleration of aging and improving the work of the brain, promotes weight loss. Thanks to the incoming calcium, the density of bone tissue enhances, helps to fight osteoporosis.

Natrol DHEA 25 MG 180 Tab

The drug with an average dosage of DHEA 25 mg 180 tablets is recommended for the normalization of hormonal balance and ammunication gain, prevents age-related changes. As well as the previous preparation is supplemented with calcium. Produced in large packaging, designed for 6 months of reception. A more advantageous offer for those who have long hormone therapy, as well as for families where several people at once need to receive DHA.

Natrol DHEA 50 MG 60 Tab

DBEA 50 mg of 60 pills with high concentration of active substance is designed to replenish a serious dehydrotestosterone deficiency. It helps to strengthen the immunity and increase bone strength, improves well-being, slows down the processes of aging, improves memory, attention, helps to fight depression. Like other drugs DHEA Natribol, this product is enhanced by calcium.

DHEA application instructions

Take DHEA needs strictly according to the instructions and / or on the purpose of the specialist, usually recommend drinking 1 capsule 1 time per day during meals. The dosage of the drug depends on the goals for which it is received. The initial (minimum) dosage for women is 5 mg, for men - 10. It is recommended to those who want to slow down aging and improve memory. For disease therapy, the concentration of the substance is usually selected above. The maximum recommended dose is 50 mg per day, is appointed by a specialist.

Contraindications

Despite the greater benefit and easy tolerability of drugs with DHEA, the instructions for the use of which is located in each pack, they still have contraindications to use. Bad with this hormone cannot be taken with cancer or precancerous states (for example, during dysplasia) ovaries, cervix and mammary glands in women, prostate glands in men, as well as at a low level of HDL ("good" cholesterol).

During pregnancy and lactation period, the doctor may appoint a woman to receive DHEA, but therapy in this case will be carried out under the strict control of the specialist. On your own decide on the reception of DHEA, like any other hormones, is strictly prohibited during pregnancy. With caution and under the control of a specialist, such dietary supplements are needed and persons suffering from impaired adrenal and thyroid functions, as well as young people under the age of 18.

Definition method HPLC-MS-MS (highly efficient liquid chromatography with mass spectrometric detection)

The material under study Serum blood

Available Departure to the house

Online registration

Synonyms : Dehydroepyondrosterone unconjugated; DGA; Dae.

DHEA; Dhea Blood Test, unconjugated; Androstenolone.

Brief description of the dehydrated dehydroepiyrostrosterone (DHEA)  

DHAA non-conjugated (as well as DGEA-sulfate) is used in the differential diagnosis of hyperandogenic states, diagnostics of violations of puberty.

For what purpose determine the dehydroepiypidrosterone in the blood

Dehydroepiyndrosterone (DHEA) is one of the androgens produced by adrenal glands (including DHEA-Sulfat, Androtandion, etc.). The study of DGEA and DHEA-sulfate in a complex with other gender steroids is used in the differential diagnosis of hyperandogenic states: polycystic ovary syndrome, congenital adrenogenital syndrome, virilizing adrenal tumors, premature adrenarche (early puberty with increased androgens products) or late puberty. The androgenic activity of DHEA and DHEA-sulfate is weak, but in peripheral tissues they can be transformed into active androgens (testosterone, dihydrotestosterone), as well as in estrogens.

In most clinical situations, the use of DHEA or DHA-sulfate test (see Test No. 101) is interchangeable. DGEA and DGEA-sulfate forms in the body can move in each other: DHEA under the action of the sulfotransferase enzyme is converted to DGEA-sulfate (DGEA-SO4, DGEA-S), and the steroid sulfate enzyme translates DHEA sulfate to DHEA. The main amount of DHEA is secreted in the form of DHEA sulfate. Both forms are associated with albumin, but DHEA sulfate is stronger.

The rate of removal of DHEA-sulfate blood is significantly lower, its concentration in the blood is more than 100 times higher than the concentration of DHEA, and does not have noticeable daily oscillations. Therefore, the measurement of DHEA-sulfate is more reliable and preferable compared to non-conjugated DGEA and is used to assess the synthesis of androgens predecessors with adrenal glands and directly level of DGEA synthesis.

What can affect the results of determining dehydroepiyndrosterone in the blood

The concentration of DGEA in the blood shows a pronounced dependence on age - gradually rises in childhood and during puberty, rapidly grows after a purrt with a peak at the age of 20 ("Fountain of Youth"), then gradually decreases.

The decrease in the level of DHEA in old age is more pronounced than for other steroids. This feature attracted attention to the study of the possible positive effects of the appropriate replacement therapy. Currently, there are no generally accepted clinical recommendations for the use of substitution therapy with the use of DHEA or DHEA-Sulfate with age deficit and on biochemical monitoring of such therapy. However, in cases of applying DHAA additives, due to in vivo, DGEA conversion in DHEA-sulfate It is possible to study DHEA (HPLC / mass spectrometry) and DHEA-sulfate (by immunoassay) to control the impact and prevent possible hyperandogenic effects when the normal concentrations of this hormone are exceeded in blood.

Data accumulates about possible DHA functions in the central nervous system. It should be borne in mind that the level of DHEA or DHAA-sulfate in the blood may not reflect changes in their level in the CNS.

Literature

  1. Goncharov N.P., Katition G.V. Dehydroepiyndrosterone: biosynthesis, metabolism, biological effects and clinical use (analytical review) .- Andrology and genital surgery. 2015; 1: 13-22.
  2. Clinical leadership of Tits on laboratory tests (ed. Alan H.B.WU). - m.; Ed. Laboral. 2013: 1280.
  3. Goodarzi M.O., Carmina E., Azziz R. Dhea, Dheas and PCOS. The Journal of Steroid Biochemistry and Molecular Biology. 2015; 145: 213-225.
  4. Rutkowski K. et al. DEHYDROEPIANDROSterone (DHEA): Hypes and hopes. Drugs. 2014; 74 (11): 1195-1207.
  5. Materials MAYO MEDICAL LABORATORIES: https://www.mayomedicallaboratories.com
  6. Materials manufacturer of reagents.

Dehydroepyondrosterone (DHEA) is a steroid hormone, the predecessor of Androgen (male genital hormones). It has an action on androgen receptors. However, DHEA as a medicine is appointed to women.

What the DHEA is responsible why he is important for women and why do he appointed gynecologists doctors, you will learn from this article.

What is DGEA in women?

There are two forms of this hormone in the body: DHEA and DHEA sulfate. Like other steroid hormones, it is formed in adrenal glands from cholesterol. Interestingly, the same enzyme (17-alpha-hydroxylase) is involved in the synthesis of DHAA, which is responsible for the synthesis of progesterone, one of the main female hormones.

DHEA is the predecessor of androgens and estrogen. There is evidence that it has anabolic activity and helps in a set of muscle mass. It is also prescribed in the form of dietary dubbing at hormonal imbalance, especially in the menopacteric period.

The role of DGEA in the body

DHAA together with other hormones provides reproductive health of men and women. It is also called the main anti-stress hormone.

There is an opinion that the decrease in DHEA is associated with:

  • Allergies and autoimmune diseases;
  • Fatigue, depression;
  • Diseases of the cardiovascular system;
  • Osteoporosis;
  • Frequent infections.

The immune system in men and women is affected by sex hormones. Moreover, estrogens specifically change the type of immune response to reduce the risk of rejection of the fetus, but at the same time increases the predisposition to allergies and autoimmune diseases - such is a fee for pregnancy. Thus, women are more susceptible to allergic and autoimmune diseases than men.

Therefore, when DGEA is lowered in women, they can assign it with not only to adjust the hormonal background, but also as complex therapy. However, before the admission of any hormonal drug, it is necessary to undergo diagnosis and consult with the doctor.

Lab Diagnostics DGEA

Blood analysis on DGEA and DHEA-sulfate in women and men are prescribed in the following cases:

  • For differential diagnosis of adrenal and genital diseases;
  • To evaluate the functional activity of adrenal glands;
  • In suspected oncology;
  • As part of the Diagnostics of the SEC (polycystic ovarian syndrome);
  • When preparing for Eco and complex diagnosis of infertility;
  • With primary amenorrhea in girls;
  • With suspected excess androgens in men and women;
  • With premature sex ripening boys.

Women are advised to hand over blood in the first half of the menstrual cycle. An accurate day is determined by the doctor.

The DHAA value is highly dependent on age and amounts to:

Age

Norm, μg / dl

Teenagers up to 15.

25 - 280.

Girls 15-20.

65 - 386.

Yunoi 15-20.

70 - 492.

Women (20-55)

146 - 256.

Men (20-55)

211 - 331.

Older people over 65

12 - 249.

If DGEA-sulfate is increased significantly, it may be a formidable symptom of hormone-producing adrenal tumors. If a tumor is suspected, the doctor will appoint additional diagnostics. In this case, it is possible to lower DHEA only after adequate treatment of the underlying disease.

High DHAA is leading in premature sexual ripening in boys and masculinization in women and girls. Masculinization is manifested by the following symptoms:

  • Low voice;
  • Pronounced "Adamovo Apple";
  • Girsutism (many hair on the body);
  • Male type baldness (bald);
  • Acne and acne;
  • Deposition of fats for male type (abdominal in the "Rescue Circle" type);
  • Male type of figure when the shoulders are wider hidden.

If DHEA is lowered, it can talk about adrenal failures or pituitary glands (hypocituitarism). In this case, drug therapy is necessary. But if DGEA is slightly lowered, either located on the lower boundary of the norm, you can try to increase it with an alimentary way (with food).

Free lesson with practitioners

Demo lessons on the program "Nutriciology"

DHAA in food

Learning the composition of food and ways to influence the human body is engaged in the science of nutritiology. It systematizes knowledge not only about vitamins and microelements, but also antioxidants, biogenic stimulants, phytohormones.

Phytoogormons - vegetable analogues of human hormones. Practice shows that the increase in their share in the diet has a beneficial effect on the hormonal background.

Also do not forget about animal products. One of the products containing hormones (primarily androgens) is solid milk. Therefore, with the symptoms listed above (SEC, acne and hirsutism), its use should be limited. Also, the content of anabolic steroids can be high in meat and fish, so they are often called "male" products.

Since DGEA is synthesized from cholesterol, it is important that an adequate amount of animal fats be present in the diet. Cholesterol is rich:

  • Eggs;
  • Sub-products (liver, brains, heart, language);
  • Red meat;
  • Fat bird and to a lesser degree of fish.

With a lack of DHEA, it is also possible to recommend potatoes and a batt, since some manufacturers of DHEA additives use them as raw materials for product.

And it is important not to forget that healthy rational food is not so much without exercise and full sleep. These three components resemble the parable of three branches, each of which is individually breaking easily, and they become stronger. Similarly, human hormonal health requires an integrated approach.

Scientific Editor: M. Merkushev, PSPBGMU. Acad. Pavlova, therapeutic case. September 2018.

Synonyms: Dehydroepiandrosterone Sulfate, DHAAS, DEA-SO4, Dae-C, Dehydroepiandrosterone Sulfate, Dhea-S

General

Dehydroepiandrosterone Sulfate (DEA-SO4) is a male sex hormone, which plays a role in the development of secondary sexual signs of both men and women. Also, DEA-SO4 is considered the "progenitor" of steroid hormones, since it is capable of transforming into estradiol, testosterone, dihydrotestosterone.

Analysis on DEA-SO4 allows you to reveal violations of the functioning of endocrine and sexual systems, oncological neoplasms, dysfunctions of internal organs. Of particular importance, this test has in the diagnosis of problems with reproductive health and non-peculiarity of pregnancy.

Dehydroepyondrosterone sulfate, like other steroid androgen hormones, is secreted by adrenal glands (95%). DEA-SO4 is one of the most important products of the endocrine system, since 27 other hormones are produced on its base.

DEA-SO4 functions

  • Slows the processes of aging cells (therefore, it is called "elixir youth");
  • Responsible for the growth of muscle mass (natural anabolic);
  • Provides a full-fledged sex life: potency, libido;
  • Regulates the menstrual cycle in women, as well as the period of occurrence of menopause;
  • Splits "bad" cholesterol in blood;
  • Contributes to the secretion of placenta estrogen, is responsible for nulling the fetus in women;
  • Strengthens the cardiovascular system;
  • It has a positive effect on the work of the TSN neurons.

On a note: The newborn DEA-SO4 can increase slightly, then a sharp decline is observed (up to a seven-year-old). The increase in the level of hormone in the plasma is also observed when the half-armed age is reached (12-16 years). Peak concentration is noted by 30 years, after which the secretion of the hormone decreases. And to the eighth dozen adrenal glands produce no more than 5% DEA-SO4.

In women, the high concentration of DEA-SO4 can lead to hyperandrode (excess androgenic hormones in the body). This pathology provokes the occurrence of a cyst, the seal of the ovarian shell, which can cause infertility and hirsutism. If the increase in the level is fixed in pregnant women, then the threat may arise Interrupts pregnancy or Premature birth .

In men, the increase in the values ​​of the DEA-SO4 may indicate developing oncological processes in adrenal glands and tests.

A consistently high level negatively affects the sexual function and the potency of a man leads to elevated exhaustion (hirsutism), a nutritional set, infertility.

Reducing the concentration of hormone in men and women is most often observed in the delay in sexual development and after the completion of the reproductive period.

Interestingly, it is at DEA-SO4 that there are no significant daily fluctuations, like other hormones.

Definition of DEA-SO4 replaces the definition of 17-CC in the urine when assessing the production of androgens adrenal glands.

Indications

  • Comprehensive examination of the endocrine system;
  • Clarification of the preliminary diagnosis of diseases associated with the insufficiency of ovarian functions and the test;
  • Diagnosis and control of the treatment of endocrine neoplasms (cancer of the adrenal cortex, hyperplasia, ACTG-secreting tumors, etc.);
  • Additional diagnosis of polycystic ovarian syndrome;
  • Determining the causes of the impairment of the menstrual cycle (amenorrhea, oligomenorrhea, annotulation);
  • Diagnosis and control of infertility treatment;
  • Girsutism in women (collaboration on androgen type);
  • Determination of the causes of masculinization (the accumulation of secondary sexual signs of male floor) in girls;
  • Study the causes of premature sexual ripening of children up to 10 years;
  • Diagnosis of adrenogenital syndrome (violation of the synthesis of corticosteroids in adrenal glands);
  • Identification of the causes of the hypotrophy of the fetus (the delay of intrauterine development);
  • Diagnosis and treatment of non-banking pregnancy;
  • Determination of the state of the fetotic placental complex, starting from 12 weeks of pregnancy;
  • Screening as part of the study on other hormones of sexual and endocrine system;
  • Identification of the causes of acne, fatty seborrhea, baldness.

The interpretation of the results is engaged in specialists: pediatrician, therapist, family doctor, gynecologist, andrologist, urologist, endocrinologist, etc.

DEA-SO4 norms

It is worth noting that in various laboratories, the norms may differ - this is due to the specifics of the reagents and equipment used.

When deciphering, it is always necessary to use the reference values ​​adopted in the laboratory, which conducted a study.

DEA-C standards adopted in Invitro laboratories 1:

Age

Floor Norms, μmol / l
1-5 years old both <2,48.
5-10 years old both <4,86.
10-14 years old both 0.7-10,32
14-20 years old Women 1.7-13.4
husband 1.2-10.4
20-25 years old Women 3.6-11,1
husband 6.5-14.6

25-35 years old

Women 2.6-13.9
husband 4.6-16,1
35-45 years old Women 2.0-11,1
husband 3.8-13,1
45-55 years old Women 1.5-7.7
husband 3.7-12,1

> 55 years old

Women 0.8-4.9
husband 1.3-9.8

References in Helix Lab 2:

Age

References

Children

<1 weeks

108 - 607 μg / dl

1-4 weeks

31.6 - 431 μg / dl

1-12 months

3.4 - 124 μg / dl

1-5 years old

0.47 - 19.4 μg / dl

5-10 years old

2.8 - 85.2 μg / dl

Women

10-15 years old

33.9 - 280 μg / dl

15-20 years old

65.1 - 368 μg / dl

20-25 years old

148 - 407 μg / dl

25-35 years old

98.8 - 340 μg / dl

35-45 years old

60.9 - 337 μg / dl

45-55 years old

35.4 - 256 μg / dl

55-65 years old

18.9 - 205 μg / dl

65-75 years old

9.4 - 246 μg / dl

> 75 years old

12 - 154 μg / dl

Men

10-15 years old

24.4 - 247 μg / dl

15-20 years old

70.2 - 492 μg / dl

20-25 years old

211 - 492 μg / dl

25-35 years old

160 - 449 μg / dl

35-45 years old

88.9 - 427 μg / dl

45-55 years old

44.3 - 331 μg / dl

55-65 years old

51.7 - 295 μg / dl

65-75 years old

33.6 - 249 μg / dl

> 75 years old

16.2 - 123 μg / dl

In professional medical literature, you can find the following DEA-C:

Handbook A.A. Kischina 3:

DHEA-S.

Directory LA Danilova 4:

DHEA-S.

Factors of influence on the result

  • Long starvation (posts, diets, unloading days, vegetarianism);
  • Heavy sports activities, lifting weights;
  • Stress, nervous overvoltage;
  • Harmful habits (smoking, alcohol consumption);
  • Therapy with drugs (danazole, clomiphene, corticotropin, hormones, dexamethasone, Finlepsin);
  • Excess body weight.

Important! The interpretation of the results is always carried out comprehensively. Put an accurate diagnosis on the basis of only one analysis is impossible.

Enhance values

  • Good and malignant formations of endocrine, sexual systems;
  • The presence of ACTG secreting tumors;
  • Ectopic adrenal hyperfunction on the background of cancer processes (lung cancer, urinary bubble, pancreas, etc.);
  • Incenko-Cushing syndrome (increased secretion of adrenal hormones, including steroids);
  • Feto-placental insufficiency (structural pathologies of the functioning of the placenta);
  • Girsutism among women;
  • The threat of the intrauterine death of the fetus, interrupting pregnancy;
  • Adrenogenital syndrome;
  • Hypothalamic-pituitary syndrome - Incenco-Cushing disease (brain tumor provokes reinforced adrenal operations);
  • Early puberty (true and false).

On a note: Increased hormone concentration in the period of periods is natural protection against osteoporosis.

The high level of DEA-SO4 in women in menopausus can cause depression, and the reception of replacement therapy with DEA ​​can increase the symptoms of depression in some women 5.

Lowering values

  • Intrauterine infection;
  • Hypoplasia of adrenal glands of the fetus;
  • Insufficient function of mother's adrenal glands;
  • Progression Diseases Addison (adrenal hormone deficiency);
  • Shikhan syndrome (postpartum infarction or pituitary necrosis);
  • PHIPPOPUITUTICOM (reduction in the level of pituitary hormones);
  • Neoplasms of the hypothalamus, pituitary
  • Polycystic ovarian syndrome ;
  • Osteoporosis ;
  • Intoxication of alcohol as a result of long-term use;
  • Reception of drugs (for example, Gestagen).
  • Long psychosocial stress;
  • Emotional burnout syndrome in young patients 6.

Preparation for analysis

Biomaterial for research: plasma of venous blood.

The method of the fence: venopunction according to the standard algorithm.

Blood fence time: not limited.

Basic requirements for training

During the day to research:

  • eliminate fatty, fried, sharp and smoked dishes from diet, as well as products containing iodine;
  • Do not drink alcoholic and tonic drinks (coffee, ginger and green tea, energy);
  • Ensure a full physical and mental peace;

2 days:

  • Stop receiving hormonal drugs:
    • hydrocortisone;
    • prednisone;
    • dexamethasone;
    • Diprospan;
    • oral contraceptives;

For 3 days:

Additional recommendations

  • It is desirable to observe 4-5 hours of fasting (non-carbonated water to drink) to venopunction.
  • In women, blood fence is made not earlier than 7 days after menstruation (on the 8-10th day of the cycle);
  • Pregnant or women in menopause must define their current status;
  • 30 minutes before manipulation, it is necessary to take a sitting (lying) position and fully relax;
  • 3 hours before the study is forbidden to smoke.

Despite the fact that the level of dehydroepiderosterone sulfate does not change during the day, the test is recommended to be carried out in the morning.

Sources:

  • 1. Invitro laboratory data
  • 2. Helix Lab Database
  • 3. A.A.Kushkun, D.M., prof. Guide for laboratory methods of diagnostics, - Gootar Media, 2007.
  • 4. L.A. Danilova, D.M., prof. Blood tests, urine and other human biological fluids in various age periods - Spetslite, 2014.
  • 5. Mary Frances Morrison. Higher Dhea-S (Dehydroepiandrosterone sulfate) Levels Are Associated with Depressive Symptoms During The Menopausal Transition: Results from The Penn Ovarian Aging Study. - Archives of Women's Mental Health, Oct. 2011.
  • 6. A.-K. Lennartsson. Low Levels of Dehydroepiandrocterone Sulfate in Young Burnout Patients. - Plos One, Oct, 2015.

We tell about DHAA with a hormone, what are these women, what are the norms and causes of deviations. DHEA C (dehydroepiyndrosterone sulfate) is an inactive (backup) DHAA form (the most important androgen synthesized by adrenal glands). This hormone plays a crucial role in the process of puberty, forming secondary male genital signs, converting estrogen to testosterone, etc.

DHEA with hormone is a laboratory indicator that allows:

  • determine the presence of adrenal pathologies;
  • to diagnose the horminate of adrenal functions;
  • carry out the differential diagnosis of adrenal and ovarian diseases;
  • clarify the causes of long infertility and the absence of puberty;
  • perform diagnostics of polycystic ovarian syndrome;
  • carry out the primary diagnosis of adrenal cancer;
  • To identify the factors for the development of secondary sexual signs on the male type in girls.

The cost of research in private laboratory departments is about 300 rubles. Analysis on DHEA appoints a doctor therapist, a gynecologist, an endocrinologist or a reproductist.

Content

DHEA hormone- What is it for women?

Despite the fact that DHA Sulfat refers to male sex hormones, its meaning in the body of women is also great. Its feature is the ability of transformation into other sex hormones, for example, estrogen. The main control over the content of DHEA is carried out by the pituitary gland using the adrenocorticotropic hormone.

Based on the fact that the main part of the substance under consideration is synthesized by adrenal glands, it can serve as a marker of their work. The hormonal effect of DHA Sulfate on the female body is implemented by stimulating the development of secondary sexual signs during puberty, as well as through it to be transformed into estradiol. In the future, it supports the reproductive health of the woman, acting as a reserve estrogen.

After conceiving a child in the body of a woman, the hormone content is somewhat reduced. For a future mother and developing fetus, it is necessary for the further synthesis of estrogen placenta.

The norm of DHA Sulfate in women

The maximum concentration is characteristic of newborns. After 2 weeks, the hormone level is reduced. During puberty, the hormone level rises, as it is necessary for the full formation of secondary sexual signs. After twenty years, the hormone level is reduced.

Let us consider in more detail what the DEA-SO4 rate in women is suitable for each age. Standard measurement units are MKG / DL. For conversion in the μmol / l, you should use the formula: μg / dl x 0.02714 = μmol / l.

Patient age NORMAL VALUE OF HORMON DHAA, ICG / DL
Newborn up to 1 week 105 - 600.
2 - 4 weeks 30.9 - 429.
Up to 1 year 3.5 - 120.
16 years 0.5 - 19,2
6 - 11 years 2.5 - 84.7
11 - 16 years 32.5 - 278.
16 - 20 years 64.8 - 365.
20 - 26 years 140 - 410.
26 - 35 years 99 - 338.
35 - 47 years (premenopause) 61 - 340.
47 - 55 years old (menopause) 34.9 - 250.
55 - 60 years (postmenopausa) 19.3 - 210.
60 - 75 years 9.6- 240.
Older 75 years old 12 - 150.

It should be noted that the indicator during the premanopause begins to shrink. There is a restructuring of the work of the endocrine system, the work of genital glands is oppressed. For women, it is considered normal that after the occurrence of menopause, the level of female sex hormones is reduced. In this case, the magnitude of male sex hormones increases somewhat.

When is the dehydroepyondrosterone sulfate enhanced in women?

If the patient on the results of the analysis found a normal magnitude of the laboratory indicator, the doctor makes an assumption about the normal functional activity of adrenal glands.

However, there are cases where the hormone concentration remained within the framework of permissible values ​​against the background of the development of adrenal tumors. This situation is characteristic of the early stage of the disease manifestation, when the amount of DHAA in the blood has not yet been reduced.

It should be noted that during the ovarian polycysticity, the value of the indicator does not always exceed normal values. The severity of hormonal disorders depends on the type, stage and severity of the ovarian lesion.

Tumors

One of the possible reasons for increasing the dehydroepyondrosterone sulfate in women is the formation of a tumor in the adrenal cortex. By character, the tumor can be benign or malignant, morphology and histology are different.

Symptoms of the development of adrenal tumors:

  • tremor limbs;
  • a sharp increase in blood pressure, poorly succumbing to antihypertensive therapy (only diuretic effects give a good effect);
  • pronounced and persistent tachyarhythmia;
  • pain or belly sophisticated syndrome;
  • an increase in daily urine;
  • insomnia;
  • headaches;
  • emotional instability;
  • the inability to focus;
  • Psycho-emotional deviations are increased anxiety, fear, aggression or a feeling of panic.

Hyperplasia

Another reason for the deviation of the hormone from the norm is the hyperplasia of adrenal cortex. It is manifested in the form of failures in the process of cortisol synthesis adrenal glands. The clinical picture of congenital pathology depends on which gene was damaged or mutated. The disease can manifest itself in the form of extensive mutations of internal organs, which are incompatible with life, or barely noticeable signs without pronounced clinical symptoms.

Important: DHAA Sulfate hormone unacceptably attribute to the diagnostic criterion for the development of specific pathology, it is only an indication of the doctor about the need for additional laboratory and instrumental diagnostics.

Incenko Cushing's disease

In the case of Incenko-Cushing disease, the high content of hormone in the blood of the patients is due to an excessive hormone-defining pituitary function. The prevalence of the disease does not exceed 1 new detected case by 1 million people annually. It should be noted that in women the disease is revealed 5 times more often.

Etiology is not fully clarified. It is assumed that the manifestation of the disease occurs after mechanical injuries of the head, infectious infection, and in women - after childbirth.

The forecast of the outcome is determined by the age of the patient and the degree of progression of pathology:

  • If a woman is less than 30 years old and the disease, Itsenko-Kushina has recently manifested itself, then the forecast is favorable;
  • In the case of a long period of medium gravity, even after the restoration of normal adrenal operations, patients detect irreversible changes: violations in the work of the cardiovascular and urinary system, the manifestation of diabetes and osteoporosis;
  • With a heavy stage, surgical treatment is shown. This leads to the need for lifelong replacement hormone therapy.

Others

Also, the level of DHEA may increase with the adrenogenital syndrome (congenital pathology of adrenal glands, accompanied by a violation of their hormonsinthetic function).

What does the hormone indicator displacement in a smaller side?

Reducing the number of dehydroepiderosterone sulfate in the blood indicates:

  • oppression of normal adrenal operations;
  • Hyponituitarianism, in which a combined decrease in the production of thyroid hormones, pituitary glands and adrenal glands is observed. The reasons for the development of pathology - poisoning to toxic substances, injuries, autoimmune diseases, the effects of ionizing radiation or oncology. There is a gradual atrophy of the heels of the endocrine system;
  • development of intrauterine infections;

Infatative reasons include the reception of progestogen - these are drugs based on steroid hormones. They are appointed when preparing a woman to successfully conceive and further maintain pregnancy.

When should I pass a hormone analysis of DGEA?

Pass the study is necessary at the first signs of failures in the work of adrenal glands or excessive androgen. At the same time, a woman has a lack of or irregular menstrual cycle, long-term infertility and masculinization. Signs of hormonal violation of the increase in the level of androgens in women:

  • abundant hair cover on the body;
  • low voice;
  • Head baldness;
  • reduction of the size of the mammary glands;
  • termination of menstruation;
  • growing kadyk;
  • abundant rich rash on the skin;
  • aggressiveness, frequent mood swings;
  • Appearance of stretch marks (Striy) on the skin;
  • reduction of sexual attraction;
  • dryness of the vagina;
  • infertility;
  • Increase the size of the clitoris in the normal structure of the internal genitals.

How to prepare for analysis on DGEA?

The preparation rules are standard as for any hormonal research. Venous blood is surrendered in the morning after night starvation. It is desirable on the eve of the visit to the laboratory department to exclude fatty and smoked food from diet, as well as alcohol. To facilitate the venopunction process, it should be used on the eve of a minimum of 0.5 liters of net non-carbonated water. This will allow you to sneak the blood, and also minimizes the risk of destruction of red blood cells and the formation of platelet clots in the tube.

For 2 days, cease to take preparations based on thyroid and steroid hormones. If necessary, this question must be discussed with the attending physician.

Sports workouts are postponed for 1 day. If possible, emotional overvoltage should also be avoided, since stress affects the work of the endocrine system.

Unreliable results can be given smoking, so it should be excluded at least 3 hours before the taking of biomaterial.

Treatment of increased hormone indicator DGEA among women

Therapy methods directly increase the level of hormone DHEA. The indicator itself returns to the limits of normal quantities after eliminating the main pathology, which caused its deviation.

Treatment of tumor diseases involves the use of drugs and chemotherapy. In the absence of positive dynamics, the question of the need to apply surgical treatment methods is solved.

When revealed infertility in a woman, it is necessary to carry out its complex diagnostics and choose the appropriate treatment. The causes of this state may be congenital anomalies, chronic diseases or histological incompatibility of partners.

When a woman wants to give birth to a child in the near future, she is prescribed hormonal contraceptives. After their cancellation, the probability of pregnancy occurs significantly increases. This is due to the fact that the development of androgens is suppressed, including DHEA. It should be noted that, despite the possibility of a successful occurrence of pregnancy, and its toaling, the main reason for the rejection of the hormone from the norm is not eliminated.

TOTAL

Summing up, you need to highlight:

  • Research on the level of hormone DHEA is a marker of adrenal operations;
  • To obtain the completeness of the picture, it is necessary to use additional laboratory tests;
  • The normal concentration of DGEA in the blood is estimated for each patient individually (taking into account its age);
  • The use of additives, which contains DGEA, will result in unreliable inflated indicators;
  • Successful treatment of the disease, due to which the hormone deviates the norm leads to a return of it in the framework of reference values.

Scientific Editor: M. Merkushev, PSPBGMU. Acad. Pavlova, therapeutic case. September 2018.

Synonyms: Dehydroepiandrosterone Sulfate, DHAAS, DEA-SO4, Dae-C, Dehydroepiandrosterone Sulfate, Dhea-S

General

Dehydroepiandrosterone Sulfate (DEA-SO4) is a male sex hormone, which plays a role in the development of secondary sexual signs of both men and women. Also, DEA-SO4 is considered the "progenitor" of steroid hormones, since it is capable of transforming into estradiol, testosterone, dihydrotestosterone.

Analysis on DEA-SO4 allows you to reveal violations of the functioning of endocrine and sexual systems, oncological neoplasms, dysfunctions of internal organs. Of particular importance, this test has in the diagnosis of problems with reproductive health and non-peculiarity of pregnancy.

Dehydroepyondrosterone sulfate, like other steroid androgen hormones, is secreted by adrenal glands (95%). DEA-SO4 is one of the most important products of the endocrine system, since 27 other hormones are produced on its base.

DEA-SO4 functions

  • Slows the processes of aging cells (therefore, it is called "elixir youth");
  • Responsible for the growth of muscle mass (natural anabolic);
  • Provides a full-fledged sex life: potency, libido;
  • Regulates the menstrual cycle in women, as well as the period of occurrence of menopause;
  • Splits "bad" cholesterol in blood;
  • Contributes to the secretion of placenta estrogen, is responsible for nulling the fetus in women;
  • Strengthens the cardiovascular system;
  • It has a positive effect on the work of the TSN neurons.

On a note: The newborn DEA-SO4 can increase slightly, then a sharp decline is observed (up to a seven-year-old). The increase in the level of hormone in the plasma is also observed when the half-armed age is reached (12-16 years). Peak concentration is noted by 30 years, after which the secretion of the hormone decreases. And to the eighth dozen adrenal glands produce no more than 5% DEA-SO4.

In women, the high concentration of DEA-SO4 can lead to hyperandrode (excess androgenic hormones in the body). This pathology provokes the occurrence of a cyst, the seal of the ovarian shell, which can cause infertility and hirsutism. If the increase in the level is fixed in pregnant women, then the threat may arise Interrupts pregnancy or Premature birth .

In men, the increase in the values ​​of the DEA-SO4 may indicate developing oncological processes in adrenal glands and tests.

A consistently high level negatively affects the sexual function and the potency of a man leads to elevated exhaustion (hirsutism), a nutritional set, infertility.

Reducing the concentration of hormone in men and women is most often observed in the delay in sexual development and after the completion of the reproductive period.

Interestingly, it is at DEA-SO4 that there are no significant daily fluctuations, like other hormones.

Definition of DEA-SO4 replaces the definition of 17-CC in the urine when assessing the production of androgens adrenal glands.

Indications

  • Comprehensive examination of the endocrine system;
  • Clarification of the preliminary diagnosis of diseases associated with the insufficiency of ovarian functions and the test;
  • Diagnosis and control of the treatment of endocrine neoplasms (cancer of the adrenal cortex, hyperplasia, ACTG-secreting tumors, etc.);
  • Additional diagnosis of polycystic ovarian syndrome;
  • Determining the causes of the impairment of the menstrual cycle (amenorrhea, oligomenorrhea, annotulation);
  • Diagnosis and control of infertility treatment;
  • Girsutism in women (collaboration on androgen type);
  • Determination of the causes of masculinization (the accumulation of secondary sexual signs of male floor) in girls;
  • Study the causes of premature sexual ripening of children up to 10 years;
  • Diagnosis of adrenogenital syndrome (violation of the synthesis of corticosteroids in adrenal glands);
  • Identification of the causes of the hypotrophy of the fetus (the delay of intrauterine development);
  • Diagnosis and treatment of non-banking pregnancy;
  • Determination of the state of the fetotic placental complex, starting from 12 weeks of pregnancy;
  • Screening as part of the study on other hormones of sexual and endocrine system;
  • Identification of the causes of acne, fatty seborrhea, baldness.

The interpretation of the results is engaged in specialists: pediatrician, therapist, family doctor, gynecologist, andrologist, urologist, endocrinologist, etc.

DEA-SO4 norms

It is worth noting that in various laboratories, the norms may differ - this is due to the specifics of the reagents and equipment used.

When deciphering, it is always necessary to use the reference values ​​adopted in the laboratory, which conducted a study.

DEA-C standards adopted in Invitro laboratories 1:

Age

Floor Norms, μmol / l
1-5 years old both <2,48.
5-10 years old both <4,86.
10-14 years old both 0.7-10,32
14-20 years old Women 1.7-13.4
husband 1.2-10.4
20-25 years old Women 3.6-11,1
husband 6.5-14.6

25-35 years old

Women 2.6-13.9
husband 4.6-16,1
35-45 years old Women 2.0-11,1
husband 3.8-13,1
45-55 years old Women 1.5-7.7
husband 3.7-12,1

> 55 years old

Women 0.8-4.9
husband 1.3-9.8

References in Helix Lab 2:

Age

References

Children

<1 weeks

108 - 607 μg / dl

1-4 weeks

31.6 - 431 μg / dl

1-12 months

3.4 - 124 μg / dl

1-5 years old

0.47 - 19.4 μg / dl

5-10 years old

2.8 - 85.2 μg / dl

Women

10-15 years old

33.9 - 280 μg / dl

15-20 years old

65.1 - 368 μg / dl

20-25 years old

148 - 407 μg / dl

25-35 years old

98.8 - 340 μg / dl

35-45 years old

60.9 - 337 μg / dl

45-55 years old

35.4 - 256 μg / dl

55-65 years old

18.9 - 205 μg / dl

65-75 years old

9.4 - 246 μg / dl

> 75 years old

12 - 154 μg / dl

Men

10-15 years old

24.4 - 247 μg / dl

15-20 years old

70.2 - 492 μg / dl

20-25 years old

211 - 492 μg / dl

25-35 years old

160 - 449 μg / dl

35-45 years old

88.9 - 427 μg / dl

45-55 years old

44.3 - 331 μg / dl

55-65 years old

51.7 - 295 μg / dl

65-75 years old

33.6 - 249 μg / dl

> 75 years old

16.2 - 123 μg / dl

In professional medical literature, you can find the following DEA-C:

Handbook A.A. Kischina 3:

DHEA-S.

Directory LA Danilova 4:

DHEA-S.

Factors of influence on the result

  • Long starvation (posts, diets, unloading days, vegetarianism);
  • Heavy sports activities, lifting weights;
  • Stress, nervous overvoltage;
  • Harmful habits (smoking, alcohol consumption);
  • Therapy with drugs (danazole, clomiphene, corticotropin, hormones, dexamethasone, Finlepsin);
  • Excess body weight.

Important! The interpretation of the results is always carried out comprehensively. Put an accurate diagnosis on the basis of only one analysis is impossible.

Enhance values

  • Good and malignant formations of endocrine, sexual systems;
  • The presence of ACTG secreting tumors;
  • Ectopic adrenal hyperfunction on the background of cancer processes (lung cancer, urinary bubble, pancreas, etc.);
  • Incenko-Cushing syndrome (increased secretion of adrenal hormones, including steroids);
  • Feto-placental insufficiency (structural pathologies of the functioning of the placenta);
  • Girsutism among women;
  • The threat of the intrauterine death of the fetus, interrupting pregnancy;
  • Adrenogenital syndrome;
  • Hypothalamic-pituitary syndrome - Incenco-Cushing disease (brain tumor provokes reinforced adrenal operations);
  • Early puberty (true and false).

On a note: Increased hormone concentration in the period of periods is natural protection against osteoporosis.

The high level of DEA-SO4 in women in menopausus can cause depression, and the reception of replacement therapy with DEA ​​can increase the symptoms of depression in some women 5.

Lowering values

  • Intrauterine infection;
  • Hypoplasia of adrenal glands of the fetus;
  • Insufficient function of mother's adrenal glands;
  • Progression Diseases Addison (adrenal hormone deficiency);
  • Shikhan syndrome (postpartum infarction or pituitary necrosis);
  • PHIPPOPUITUTICOM (reduction in the level of pituitary hormones);
  • Neoplasms of the hypothalamus, pituitary
  • Polycystic ovarian syndrome ;
  • Osteoporosis ;
  • Intoxication of alcohol as a result of long-term use;
  • Reception of drugs (for example, Gestagen).
  • Long psychosocial stress;
  • Emotional burnout syndrome in young patients 6.

Preparation for analysis

Biomaterial for research: plasma of venous blood.

The method of the fence: venopunction according to the standard algorithm.

Blood fence time: not limited.

Basic requirements for training

During the day to research:

  • eliminate fatty, fried, sharp and smoked dishes from diet, as well as products containing iodine;
  • Do not drink alcoholic and tonic drinks (coffee, ginger and green tea, energy);
  • Ensure a full physical and mental peace;

2 days:

  • Stop receiving hormonal drugs:
    • hydrocortisone;
    • prednisone;
    • dexamethasone;
    • Diprospan;
    • oral contraceptives;

For 3 days:

Additional recommendations

  • It is desirable to observe 4-5 hours of fasting (non-carbonated water to drink) to venopunction.
  • In women, blood fence is made not earlier than 7 days after menstruation (on the 8-10th day of the cycle);
  • Pregnant or women in menopause must define their current status;
  • 30 minutes before manipulation, it is necessary to take a sitting (lying) position and fully relax;
  • 3 hours before the study is forbidden to smoke.

Despite the fact that the level of dehydroepiderosterone sulfate does not change during the day, the test is recommended to be carried out in the morning.

Sources:

  • 1. Invitro laboratory data
  • 2. Helix Lab Database
  • 3. A.A.Kushkun, D.M., prof. Guide for laboratory methods of diagnostics, - Gootar Media, 2007.
  • 4. L.A. Danilova, D.M., prof. Blood tests, urine and other human biological fluids in various age periods - Spetslite, 2014.
  • 5. Mary Frances Morrison. Higher Dhea-S (Dehydroepiandrosterone sulfate) Levels Are Associated with Depressive Symptoms During The Menopausal Transition: Results from The Penn Ovarian Aging Study. - Archives of Women's Mental Health, Oct. 2011.
  • 6. A.-K. Lennartsson. Low Levels of Dehydroepiandrocterone Sulfate in Young Burnout Patients. - Plos One, Oct, 2015.

We all strive to look young and energetically, have a good mood and an excellent physical form. And it's no secret that hormones are responsible for youth - DHEA, Growth Hormone, Estrogen and Testosterone. In this article we will discuss DHEA (DehyrehedoepiyRostrosteron) , His promising effects in the body, as well as The consequences of high and low levels of DSEA in the blood in women of reproductive age, the reasons for its decline and increase.

DHEA captured public and scientific imagination as a hormone against aging. It was characterized as "Maternal hormone" - the predecessor of all steroid hormones, but it is not so - this honor belongs Prognenolon , (Figure below). Nevertheless, the hormone is very interesting, it has been studied for more than 40 years.

According to Dr. Ronald Clutz, President of the American Academy of Anti-aging medicine - "The level of DGEA in human blood is an excellent indicator of not only age-related health problems, but also an aging indicator as such."

What is DGEA?

DHEA (DehydroepiyRostrosteron) is a steroid hormone , known as Androgen. It is produced by an organism of cholesterol by 95% of adrenal cortex and 5% ovaries / semenniki. It is the most important Hormone stress adaptation.

Also, adrenal glands produce another one Active metabolite - DGEA-C which has more sexual and metabolic functions, has a longer half-life than DHEA, and small daily fluctuations, which makes DGEA-with more convenient for laboratory diagnostics. These two forms of hormone can move into each other.

In the image, the steroid hormone transformation chain, DHEA refers to the "right shoulder" hormone synthesis:

Dhea-Synthesis

DHEA is synthesized from 17-hydroxypnesenenolone (Pershegnalon metabolite), is the predecessor of testosterone and estrogen But it also has direct cell action by itself.

The concentration of this hormone reaches a peak in youthful age and then Reduced at a rate of ~ 20% over a decade . In the elderly, the DHAE level is only 10% of the peak source value. One of the reasons for this reduction is the violation of the enzyme activity of 17,20-desmolase, found in adrenal glands and partly responsible for the production of DGEA.

When the ovaries begin to disconnect, DHEA becomes the main source of hormones in the female body, so it is important to pay due attention to this hormone.

Effects and action of DHEA

Understanding how DHEA works, helps us understand why it is important that its level in the body is optimal - not too high or low.

  • Increases the density and formation of bones
  • Increases cell sensitivity to insulin (insulin production level decreases)
  • Increases glucose seizure with tissues (decrease in blood glucose)
  • Increases the growth of muscle tissue
  • Reduces fatty tissue due to activation of lipolysis (more characteristic of the active metabolite 7-keto DHEA)
  • Reduces the risks of cardiovascular diseases due to the regulation of the balance of cholesterol and reduce the risks of atherosclerosis
  • Improving elasticity, elasticity and nutrition of skin
  • Increases the growth of vaginal epithelium
  • Improves sexual behavior (raises libido)
  • Reduces the manifestation of Klimaks
  • Pains pain and improves mood (due to beta endorphins
  • Improves memory, mental activity, reaction rate
  • Improves physical strength and endurance due to stimulation of testosterone production
  • Is a herooprotector (increases active longevity)
  • Supports energy processes in cells by stimulating ubiquinone production and coenzyme Q10 (anti-acdanant activity)
  • Supports the immune system (control of autoimmune diseases, antitumor immunity.
  • Reducing depressive manifestations, neurosis (can be applied in therapy from dependent states: alcoholism, food addiction)
  • Improved quality and sleep duration

Yes, the effects of dehydroepiandrosterone are impressive, but as in any strong goromon there is a "reverse" party, which must be considered if you plan to use hormon-plating therapy with DHEA additives that restore this hormone level.

Ways and mechanisms for the formation of testosterone and estradiol from DHEA

Since DGEA belongs to the hormones of the "right shoulder", it is Construction material for testosterone synthesis and in the future - estradiol.

In this regard, different side effects may occur, especially if there are some diseases of the ovaries / testicles and Genetic features of testosterone conversion in estradiol.

We will analyze the basic options in women and men.

AMONG WOMEN:

✿ DGEA increases testosterone levels at normal or low estradiole. This state arises due to the deficiency of aromatase - enzyme, providing the process of converting one hormone to another. As a result, a woman develops hirsutism (increased column), problems with skin (acne), mood differences and body weight disorders and carbohydrate metabolism. ⠀ ✿ DHAA increases the level of estradiol at a normal or low level of testosterone. This state occurs due to excess aromatase production, which leads to estrogen-dominance. As a result, the risks of benign formations (mioma, fibrous-cystic mastopathy, endometriosis, adenomyosis, etc.) or malignant rebirth of tissues (breast cancer, uterine cancer, etc.) increase

In men: ⠀

✿ DGEA increases testosterone at normal or low estradiol. This can lead to a decrease in active sperm in sperm, which is fraught with problems with conception (many athletes). Also, an excess of testosterone contributes to a decrease in intelligence and improving self-confidence, which is fraught with ignoring the errors made. Risk of thrombus, heart failure, heart attacks. In addition, the high testosterone increases the risks of the liver cancer due to the suppression of adiponectin testosterone. ⠀ ✿ DHAA increases the level of estradiol at a normal or low level of testosterone. This can lead to gynecomastia (breast appearance), obesity for the female type (thigh, buttocks), a decrease in libido (and erectile dysfunction), as well as increased risk of prostate prostate adenoma and prostate cancer.

If there are already the above problems of converting DHEA to other hormones, the use of DHEA additives only will be aggravated, so the preliminary examination and advice of the doctor or a doctrine-nutritiologist!

Causes of high and low DHEA

The high level of DHEA may be observed in the following states:

  1. Chronic daily stress (stress causes the release of DHEA and cortisol from your adrenal glands, a picture of high DGEA and / or cortisol)
  2. Post-traumatic stress disorder [one] (Over time, leads to a high level of DHEA and the low level of cortisol + impaired immune function).
  3. Adrenal type of SPKya or mixed where the hereditary component is present [3] .
  4. Hyperprolaktemia (Prolactin directly increases DHEA levels [2] ).
  5. Benign or malignant education in adrenal glands
  6. Increased sensitivity of receptors to DHEA and other androgen at the cellular level (Your cells become hypersensitive even to the normal level of androgens; a picture of both high DSEA and other androgens and normal levels that are accompanied by symptoms of hyperandrode). Although this process is not entirely understood, but is considered secondary in relation to the activation of the immune system and is observed in such states as a benign prostatic hyperplasia. [four] and androgenetic alopecia (hair loss) [five] .
  7. Non-classical adrenal hyperplasia [6] (Autosomal-recessive genetic disease, which is usually manifested at a later age; High levels of DGEA, 17th progesterone + acne, hirsutism, alopecia and menstruation problems).

If you have a high level of DHEA, the most important thing to find the cause and then aiming your treatment on it.

Low DEA level is most often associated:

  • With adrenal exhaustion (Adrenal Fatigue) . Chronic long-term stress and diseases can lead to a decrease in DHEA, as well as to a decrease in its synergistic twin - the other Cortisol stress hormone.
  • Other reasons are related to: with inflammation, allergies, autoimmune diseases, sexual dysfunction, infections, insomnia, CVD, depression and cancer.

How and when to take DHEA?

DHEA analysis gives up in some cases:

  • To assess the adrenal function (in this case, it is important to see the ratio of DHEA to cortisol: DHAA-C and cortisol in serum is examined, very informatively watch cortisol and DHEA daily in saliva, but only chosen laboratories do it);
  • To identify the reasons for the excess of male hormones in women (studied DHEA-C in blood serum along with testosterone and estradiol);
  • To identify the causes of premature puberty in boys (DHAA-C in blood serum is investigated);
  • In cases of applying DGEA additives (DGEA is studied - the HPLC / mass spectrometry method and DGEA-C - the method of immunoassay serum) to control and prevent possible symptoms of hyperandrogenation when the normal concentrations of this hormone are exceeded.

If there is a cycle - take DHEA-C for 3-5 days. If there is no cycle, then you can take any day (in the morning, on an empty stomach).

Testing the DHAA level and the preservation of hormonal balance between stress hormones is the key to success towards longevity. The optimal level of DHEA will help to feel younger, stronger and more confident.

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